Utility of video capsule endoscopy for longitudinal monitoring of Crohn's disease activity in the small bowel

a prospective study

Gil Y. Melmed, Marla C. Dubinsky, David T. Rubin, Mark Fleisher, Shabana F Pasha, Atsushi Sakuraba, Felix Tiongco, Ira Shafran, Ignacio Fernandez-Urien, Bruno Rosa, Neofytos P. Papageorgiou, Jonathan A Leighton

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background and Aims: This prospective, multicenter study evaluated small-bowel capsule endoscopy (CE) for the longitudinal assessment of mucosal inflammation in subjects with Crohn's disease (CD). Methods: Subjects with known CD underwent clinical evaluation with ileocolonoscopy and CE at baseline and 6-month follow-up. Small-bowel patency was confirmed before CE at both time points. The Simple Endoscopic Score for CD (SES-CD) was used for ileocolonoscopy, and the Lewis score and the CE CD Endoscopic Index of Severity (CECDEIS) were used for CE. Clinical scoring indices included the Physician Global Assessment (PGA), CD Activity Index (CDAI), and Harvey-Bradshaw Index (HBI). Laboratory markers including C-reactive protein, fecal calprotectin, and erythrocyte sedimentation rate were collected at baseline and follow-up. Correlation between endoscopic scores and clinical parameters were measured using Spearman tests. Results: A total of 74 subjects were enrolled, of whom 53 (72%) completed endoscopic procedures at baseline and 6-month follow-up. The SES-CD ileocolonoscopy score correlated with the Lewis score (P <.001, ρ =.59) and CECDEIS capsule score (P =.002, ρ =.48). None of the 3 endoscopic scores correlated with PGA, CDAI, HBI, C-reactive protein, erythrocyte sedimentation rate, or fecal calprotectin. Approximately 85% of subjects had proximal small-bowel inflammation identified on CE. There were no CE-related adverse events. Conclusions: There was high correlation between CE and ileocolonoscopy scores for the assessment of mucosal disease activity over time; however, there were no correlations between endoscopic scores and clinical parameters. The use of serial CE for the assessment of small-bowel CD is feasible and valid. (Clinical trial registration number: NCT01942720.)

Original languageEnglish (US)
JournalGastrointestinal Endoscopy
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Capsule Endoscopy
Crohn Disease
Prospective Studies
Leukocyte L1 Antigen Complex
Blood Sedimentation
C-Reactive Protein
Inflammation
Physicians
Multicenter Studies
Capsules
Biomarkers
Clinical Trials

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

Utility of video capsule endoscopy for longitudinal monitoring of Crohn's disease activity in the small bowel : a prospective study. / Melmed, Gil Y.; Dubinsky, Marla C.; Rubin, David T.; Fleisher, Mark; Pasha, Shabana F; Sakuraba, Atsushi; Tiongco, Felix; Shafran, Ira; Fernandez-Urien, Ignacio; Rosa, Bruno; Papageorgiou, Neofytos P.; Leighton, Jonathan A.

In: Gastrointestinal Endoscopy, 01.01.2018.

Research output: Contribution to journalArticle

Melmed, Gil Y. ; Dubinsky, Marla C. ; Rubin, David T. ; Fleisher, Mark ; Pasha, Shabana F ; Sakuraba, Atsushi ; Tiongco, Felix ; Shafran, Ira ; Fernandez-Urien, Ignacio ; Rosa, Bruno ; Papageorgiou, Neofytos P. ; Leighton, Jonathan A. / Utility of video capsule endoscopy for longitudinal monitoring of Crohn's disease activity in the small bowel : a prospective study. In: Gastrointestinal Endoscopy. 2018.
@article{48632eae72854b1696342daf272b9a5b,
title = "Utility of video capsule endoscopy for longitudinal monitoring of Crohn's disease activity in the small bowel: a prospective study",
abstract = "Background and Aims: This prospective, multicenter study evaluated small-bowel capsule endoscopy (CE) for the longitudinal assessment of mucosal inflammation in subjects with Crohn's disease (CD). Methods: Subjects with known CD underwent clinical evaluation with ileocolonoscopy and CE at baseline and 6-month follow-up. Small-bowel patency was confirmed before CE at both time points. The Simple Endoscopic Score for CD (SES-CD) was used for ileocolonoscopy, and the Lewis score and the CE CD Endoscopic Index of Severity (CECDEIS) were used for CE. Clinical scoring indices included the Physician Global Assessment (PGA), CD Activity Index (CDAI), and Harvey-Bradshaw Index (HBI). Laboratory markers including C-reactive protein, fecal calprotectin, and erythrocyte sedimentation rate were collected at baseline and follow-up. Correlation between endoscopic scores and clinical parameters were measured using Spearman tests. Results: A total of 74 subjects were enrolled, of whom 53 (72{\%}) completed endoscopic procedures at baseline and 6-month follow-up. The SES-CD ileocolonoscopy score correlated with the Lewis score (P <.001, ρ =.59) and CECDEIS capsule score (P =.002, ρ =.48). None of the 3 endoscopic scores correlated with PGA, CDAI, HBI, C-reactive protein, erythrocyte sedimentation rate, or fecal calprotectin. Approximately 85{\%} of subjects had proximal small-bowel inflammation identified on CE. There were no CE-related adverse events. Conclusions: There was high correlation between CE and ileocolonoscopy scores for the assessment of mucosal disease activity over time; however, there were no correlations between endoscopic scores and clinical parameters. The use of serial CE for the assessment of small-bowel CD is feasible and valid. (Clinical trial registration number: NCT01942720.)",
author = "Melmed, {Gil Y.} and Dubinsky, {Marla C.} and Rubin, {David T.} and Mark Fleisher and Pasha, {Shabana F} and Atsushi Sakuraba and Felix Tiongco and Ira Shafran and Ignacio Fernandez-Urien and Bruno Rosa and Papageorgiou, {Neofytos P.} and Leighton, {Jonathan A}",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.gie.2018.07.035",
language = "English (US)",
journal = "Gastrointestinal Endoscopy",
issn = "0016-5107",
publisher = "Mosby Inc.",

}

TY - JOUR

T1 - Utility of video capsule endoscopy for longitudinal monitoring of Crohn's disease activity in the small bowel

T2 - a prospective study

AU - Melmed, Gil Y.

AU - Dubinsky, Marla C.

AU - Rubin, David T.

AU - Fleisher, Mark

AU - Pasha, Shabana F

AU - Sakuraba, Atsushi

AU - Tiongco, Felix

AU - Shafran, Ira

AU - Fernandez-Urien, Ignacio

AU - Rosa, Bruno

AU - Papageorgiou, Neofytos P.

AU - Leighton, Jonathan A

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background and Aims: This prospective, multicenter study evaluated small-bowel capsule endoscopy (CE) for the longitudinal assessment of mucosal inflammation in subjects with Crohn's disease (CD). Methods: Subjects with known CD underwent clinical evaluation with ileocolonoscopy and CE at baseline and 6-month follow-up. Small-bowel patency was confirmed before CE at both time points. The Simple Endoscopic Score for CD (SES-CD) was used for ileocolonoscopy, and the Lewis score and the CE CD Endoscopic Index of Severity (CECDEIS) were used for CE. Clinical scoring indices included the Physician Global Assessment (PGA), CD Activity Index (CDAI), and Harvey-Bradshaw Index (HBI). Laboratory markers including C-reactive protein, fecal calprotectin, and erythrocyte sedimentation rate were collected at baseline and follow-up. Correlation between endoscopic scores and clinical parameters were measured using Spearman tests. Results: A total of 74 subjects were enrolled, of whom 53 (72%) completed endoscopic procedures at baseline and 6-month follow-up. The SES-CD ileocolonoscopy score correlated with the Lewis score (P <.001, ρ =.59) and CECDEIS capsule score (P =.002, ρ =.48). None of the 3 endoscopic scores correlated with PGA, CDAI, HBI, C-reactive protein, erythrocyte sedimentation rate, or fecal calprotectin. Approximately 85% of subjects had proximal small-bowel inflammation identified on CE. There were no CE-related adverse events. Conclusions: There was high correlation between CE and ileocolonoscopy scores for the assessment of mucosal disease activity over time; however, there were no correlations between endoscopic scores and clinical parameters. The use of serial CE for the assessment of small-bowel CD is feasible and valid. (Clinical trial registration number: NCT01942720.)

AB - Background and Aims: This prospective, multicenter study evaluated small-bowel capsule endoscopy (CE) for the longitudinal assessment of mucosal inflammation in subjects with Crohn's disease (CD). Methods: Subjects with known CD underwent clinical evaluation with ileocolonoscopy and CE at baseline and 6-month follow-up. Small-bowel patency was confirmed before CE at both time points. The Simple Endoscopic Score for CD (SES-CD) was used for ileocolonoscopy, and the Lewis score and the CE CD Endoscopic Index of Severity (CECDEIS) were used for CE. Clinical scoring indices included the Physician Global Assessment (PGA), CD Activity Index (CDAI), and Harvey-Bradshaw Index (HBI). Laboratory markers including C-reactive protein, fecal calprotectin, and erythrocyte sedimentation rate were collected at baseline and follow-up. Correlation between endoscopic scores and clinical parameters were measured using Spearman tests. Results: A total of 74 subjects were enrolled, of whom 53 (72%) completed endoscopic procedures at baseline and 6-month follow-up. The SES-CD ileocolonoscopy score correlated with the Lewis score (P <.001, ρ =.59) and CECDEIS capsule score (P =.002, ρ =.48). None of the 3 endoscopic scores correlated with PGA, CDAI, HBI, C-reactive protein, erythrocyte sedimentation rate, or fecal calprotectin. Approximately 85% of subjects had proximal small-bowel inflammation identified on CE. There were no CE-related adverse events. Conclusions: There was high correlation between CE and ileocolonoscopy scores for the assessment of mucosal disease activity over time; however, there were no correlations between endoscopic scores and clinical parameters. The use of serial CE for the assessment of small-bowel CD is feasible and valid. (Clinical trial registration number: NCT01942720.)

UR - http://www.scopus.com/inward/record.url?scp=85054169395&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054169395&partnerID=8YFLogxK

U2 - 10.1016/j.gie.2018.07.035

DO - 10.1016/j.gie.2018.07.035

M3 - Article

JO - Gastrointestinal Endoscopy

JF - Gastrointestinal Endoscopy

SN - 0016-5107

ER -