TY - JOUR
T1 - Utility of ultrasensitive growth hormone assays in assessing aging-related hyposomatotropism
AU - Iranmanesh, Ali
AU - Veldhuis, Johannes D.
PY - 2005/12
Y1 - 2005/12
N2 - Relative hyposomatotropism in aging is significant, inasmuch as organic GH deficiency and aging have considerable overlap in GH production and clinical phenotype. Ultrasensitive GH assays and biomathematical analyses have established that aging lowers GH concentrations by attenuating the size of GH secretory bursts. This mechanism is important, because pulsatile secretion comprises the predominant (greater than 85%) mode of GH output and correlates with growth and anabolism. Diminutive GH pulses in older adults appear to reflect reduced drive by GHRH and GHRP/ghrelin on the one hand and excessive inhibition by somatostatin on the other. Further studies will be required to identify the precise causes and consequences of GH depletion in various aging populations.
AB - Relative hyposomatotropism in aging is significant, inasmuch as organic GH deficiency and aging have considerable overlap in GH production and clinical phenotype. Ultrasensitive GH assays and biomathematical analyses have established that aging lowers GH concentrations by attenuating the size of GH secretory bursts. This mechanism is important, because pulsatile secretion comprises the predominant (greater than 85%) mode of GH output and correlates with growth and anabolism. Diminutive GH pulses in older adults appear to reflect reduced drive by GHRH and GHRP/ghrelin on the one hand and excessive inhibition by somatostatin on the other. Further studies will be required to identify the precise causes and consequences of GH depletion in various aging populations.
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U2 - 10.1016/j.ecl.2005.07.005
DO - 10.1016/j.ecl.2005.07.005
M3 - Review article
C2 - 16310626
AN - SCOPUS:27944505930
SN - 0889-8529
VL - 34
SP - 853
EP - 864
JO - Endocrinology and Metabolism Clinics of North America
JF - Endocrinology and Metabolism Clinics of North America
IS - 4
ER -