Relative hyposomatotropism in aging is significant, inasmuch as organic GH deficiency and aging have considerable overlap in GH production and clinical phenotype. Ultrasensitive GH assays and biomathematical analyses have established that aging lowers GH concentrations by attenuating the size of GH secretory bursts. This mechanism is important, because pulsatile secretion comprises the predominant (greater than 85%) mode of GH output and correlates with growth and anabolism. Diminutive GH pulses in older adults appear to reflect reduced drive by GHRH and GHRP/ghrelin on the one hand and excessive inhibition by somatostatin on the other. Further studies will be required to identify the precise causes and consequences of GH depletion in various aging populations.
|Original language||English (US)|
|Number of pages||12|
|Journal||Endocrinology and Metabolism Clinics of North America|
|State||Published - Dec 1 2005|
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism