TY - JOUR
T1 - Utility of the Spanish version of the FTLD-modified CDR in the diagnosis and staging in frontotemporal lobar degeneration
AU - Russo, Griselda
AU - Russo, María Julieta
AU - Buyatti, Daniela
AU - Chrem, Patricio
AU - Bagnati, Pablo
AU - Suarez, Marcos Fernández
AU - Campos, Jorge
AU - Cohen, Gabriela
AU - Amengual, Alejandra
AU - Allegri, Ricardo F.
AU - Knopman, David S.
PY - 2014/9/15
Y1 - 2014/9/15
N2 - Introduction The Clinical Dementia Rating Scale (CDR) is a tool designed to quantify the severity of dementia symptoms and is also useful to assess disease progression, in Alzheimer's disease (AD). A new version of the scale was developed by adding two extra domains that focused on the core aspects of frontotemporal dementia symptomatology, Language and Behavior/Comportment/ Personality. Objectives In this study, we adapted and validated the modified CDR scale in our setting and language (Rioplatense-Spanish). Materials and methods 46 patients with probable AD, 27 behavioral variant of Frontotemporal Dementia (bvFTD), 18 Primary Progressive Aphasia (PPA) and 40 healthy participants were included. The adapted version of the scale was administered by a blind rater who interviewed patients together with patient's caregiver. Results Using ROC curves, the domain language and behavior were superior to the memory domain in accuracy for detecting PPA and bvFTD, respectively, but both of them had equivalent diagnostic accuracies for probable AD. Logistic regression analyses showed that either the LANG or BEHAV domains significantly improved the discrimination between probable AD, bvFTD and PPA. Conclusions The Spanish version of the modified CDR adds value for the characterization of the non-amnestic symptoms in patients with neurodegenerative dementias.
AB - Introduction The Clinical Dementia Rating Scale (CDR) is a tool designed to quantify the severity of dementia symptoms and is also useful to assess disease progression, in Alzheimer's disease (AD). A new version of the scale was developed by adding two extra domains that focused on the core aspects of frontotemporal dementia symptomatology, Language and Behavior/Comportment/ Personality. Objectives In this study, we adapted and validated the modified CDR scale in our setting and language (Rioplatense-Spanish). Materials and methods 46 patients with probable AD, 27 behavioral variant of Frontotemporal Dementia (bvFTD), 18 Primary Progressive Aphasia (PPA) and 40 healthy participants were included. The adapted version of the scale was administered by a blind rater who interviewed patients together with patient's caregiver. Results Using ROC curves, the domain language and behavior were superior to the memory domain in accuracy for detecting PPA and bvFTD, respectively, but both of them had equivalent diagnostic accuracies for probable AD. Logistic regression analyses showed that either the LANG or BEHAV domains significantly improved the discrimination between probable AD, bvFTD and PPA. Conclusions The Spanish version of the modified CDR adds value for the characterization of the non-amnestic symptoms in patients with neurodegenerative dementias.
KW - Alzheimer disease
KW - Behavior
KW - Frontotemporal dementia
KW - Neuropsychology
KW - Primary progressive aphasia
KW - Rating scales
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U2 - 10.1016/j.jns.2014.06.024
DO - 10.1016/j.jns.2014.06.024
M3 - Article
C2 - 25015844
AN - SCOPUS:84906793979
SN - 0022-510X
VL - 344
SP - 63
EP - 68
JO - Journal of the neurological sciences
JF - Journal of the neurological sciences
IS - 1-2
ER -