Utility of the Spanish version of the FTLD-modified CDR in the diagnosis and staging in frontotemporal lobar degeneration

Griselda Russo, María Julieta Russo, Daniela Buyatti, Patricio Chrem, Pablo Bagnati, Marcos Fernández Suarez, Jorge Campos, Gabriela Cohen, Alejandra Amengual, Ricardo F. Allegri, David S. Knopman

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Introduction The Clinical Dementia Rating Scale (CDR) is a tool designed to quantify the severity of dementia symptoms and is also useful to assess disease progression, in Alzheimer's disease (AD). A new version of the scale was developed by adding two extra domains that focused on the core aspects of frontotemporal dementia symptomatology, Language and Behavior/Comportment/ Personality. Objectives In this study, we adapted and validated the modified CDR scale in our setting and language (Rioplatense-Spanish). Materials and methods 46 patients with probable AD, 27 behavioral variant of Frontotemporal Dementia (bvFTD), 18 Primary Progressive Aphasia (PPA) and 40 healthy participants were included. The adapted version of the scale was administered by a blind rater who interviewed patients together with patient's caregiver. Results Using ROC curves, the domain language and behavior were superior to the memory domain in accuracy for detecting PPA and bvFTD, respectively, but both of them had equivalent diagnostic accuracies for probable AD. Logistic regression analyses showed that either the LANG or BEHAV domains significantly improved the discrimination between probable AD, bvFTD and PPA. Conclusions The Spanish version of the modified CDR adds value for the characterization of the non-amnestic symptoms in patients with neurodegenerative dementias.

Original languageEnglish (US)
Pages (from-to)63-68
Number of pages6
JournalJournal of the neurological sciences
Volume344
Issue number1-2
DOIs
StatePublished - Sep 15 2014

Keywords

  • Alzheimer disease
  • Behavior
  • Frontotemporal dementia
  • Neuropsychology
  • Primary progressive aphasia
  • Rating scales

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Russo, G., Russo, M. J., Buyatti, D., Chrem, P., Bagnati, P., Suarez, M. F., Campos, J., Cohen, G., Amengual, A., Allegri, R. F., & Knopman, D. S. (2014). Utility of the Spanish version of the FTLD-modified CDR in the diagnosis and staging in frontotemporal lobar degeneration. Journal of the neurological sciences, 344(1-2), 63-68. https://doi.org/10.1016/j.jns.2014.06.024