Utility of Subcutaneous Fat Aspiration for the Diagnosis of Systemic Amyloidosis (Immunoglobulin Light Chain)

Morie Gertz, Chin Yang Li, Tsuranobu Shirahama, Robert A. Kyle

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

To our knowledge, this is the first blind and controlled analysis of subcutaneous fat aspiration for the diagnosis of primary systemic amyloidosis. The procedure was performed on 82 patients with biopsy-proved systemic amyloidosis and 72 normal adult volunteers. Slides from 71 of the 72 controls were read as negative. Slides from 59 (72%) of the 82 patients with amyloidosis were read as positive or weakly positive after staining with alkaline Congo red. Subcutaneous fat aspiration was as sensitive as rectal biopsy and substantially more sensitive than bone marrow biopsy in diagnosing amyloidosis. In six instances fat aspiration would have obviated the need for a more invasive diagnostic biopsy. Subcutaneous fat aspiration is sensitive (72%) and specific (99%) for amyloidosis. It is technically simpler and less expensive than rectal biopsy and permits immediate assessment of specimen adequacy. The concordance rate for two independent pathologists was 95%. Equivocally positive stains should be interpreted with caution because weak nonspecific staining may be seen.

Original languageEnglish (US)
Pages (from-to)929-933
Number of pages5
JournalArchives of Internal Medicine
Volume148
Issue number4
DOIs
StatePublished - Jan 1 1988

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Immunoglobulin Light Chains
Subcutaneous Fat
Amyloidosis
Biopsy
Staining and Labeling
Congo Red
Healthy Volunteers
Coloring Agents
Bone Marrow
Fats

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Utility of Subcutaneous Fat Aspiration for the Diagnosis of Systemic Amyloidosis (Immunoglobulin Light Chain). / Gertz, Morie; Li, Chin Yang; Shirahama, Tsuranobu; Kyle, Robert A.

In: Archives of Internal Medicine, Vol. 148, No. 4, 01.01.1988, p. 929-933.

Research output: Contribution to journalArticle

Gertz, Morie ; Li, Chin Yang ; Shirahama, Tsuranobu ; Kyle, Robert A. / Utility of Subcutaneous Fat Aspiration for the Diagnosis of Systemic Amyloidosis (Immunoglobulin Light Chain). In: Archives of Internal Medicine. 1988 ; Vol. 148, No. 4. pp. 929-933.
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