TY - JOUR
T1 - Utility of Follow-up Tests for Detecting Recurrent Disease in Patients With Malignant Melanomas
AU - Weiss, Matthias
AU - Loprinzi, Charles L.
AU - Creagan, Edward T.
AU - Dalton, R. J.
AU - Novotny, Paul
AU - O’fallon, Judith R.
PY - 1995/12/6
Y1 - 1995/12/6
N2 - To determine the effectiveness of follow-up tests for signaling recurrences in patients with intermediate- and high-risk malignant melanomas treated with curative intention. Retrospective analysis of prospectively collected data. North Central Cancer Treatment Group. A total of 261 patients with resected local (≥1.69 mm) and regional nodal malignant melanomas who were enrolled in a single prospective adjuvant trial were studied. All patients were scheduled to be followed up monthly for 2 months, then every 2 months for the first year, every 4 months the second year, every 6 months the next 3 years, and annually thereafter, with each visit consisting of a history, physical examination, complete blood cell count, blood chemistry panel, and a chest x-ray. Of the 145 evaluable patients who developed recurrent melanomas, 99 patients (68%) developed symptoms that signaled the diagnosis of recurrent disease. Physical examination of asymptomatic patients led to the diagnosis of recurrent disease in 37 patients (26%). The other nine patients (6%) with recurrent disease had abnormal chest x-rays. Laboratory results were never a sole indicator of recurrent disease. The majority of recurrences following resection of primary melanomas are discovered by history and/or physical examination despite the frequent use of other follow-up tests. The present data indicate that routine blood analyses and chest x-rays have limited value in the postoperative follow-up of patients with resected intermediate- and high-risk melanomas. (JAMA. 1995;274:1703-1705).
AB - To determine the effectiveness of follow-up tests for signaling recurrences in patients with intermediate- and high-risk malignant melanomas treated with curative intention. Retrospective analysis of prospectively collected data. North Central Cancer Treatment Group. A total of 261 patients with resected local (≥1.69 mm) and regional nodal malignant melanomas who were enrolled in a single prospective adjuvant trial were studied. All patients were scheduled to be followed up monthly for 2 months, then every 2 months for the first year, every 4 months the second year, every 6 months the next 3 years, and annually thereafter, with each visit consisting of a history, physical examination, complete blood cell count, blood chemistry panel, and a chest x-ray. Of the 145 evaluable patients who developed recurrent melanomas, 99 patients (68%) developed symptoms that signaled the diagnosis of recurrent disease. Physical examination of asymptomatic patients led to the diagnosis of recurrent disease in 37 patients (26%). The other nine patients (6%) with recurrent disease had abnormal chest x-rays. Laboratory results were never a sole indicator of recurrent disease. The majority of recurrences following resection of primary melanomas are discovered by history and/or physical examination despite the frequent use of other follow-up tests. The present data indicate that routine blood analyses and chest x-rays have limited value in the postoperative follow-up of patients with resected intermediate- and high-risk melanomas. (JAMA. 1995;274:1703-1705).
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U2 - 10.1001/jama.1995.03530210057031
DO - 10.1001/jama.1995.03530210057031
M3 - Article
C2 - 7474276
AN - SCOPUS:0028788239
SN - 0098-7484
VL - 274
SP - 1703
EP - 1705
JO - JAMA: The Journal of the American Medical Association
JF - JAMA: The Journal of the American Medical Association
IS - 21
ER -