Utility and applications of orthotopic models of human non-small cell lung cancer (NSCLC) for the evaluation of novel and emerging cancer therapeutics

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Lung cancer is a leading cause of cancer deaths worldwide. Despite advances in chemotherapy, radiation therapy, and surgery, lung cancer continues to have a low 5-year survival rate, highlighting a dire need for more effective means of prevention, diagnosis, prognosis, and treatment. Mouse models that recapitulate the clinical features of advanced human lung cancer are critical for testing novel therapeutic approaches. This unit describes a highly reproducible, easy-to-establish orthotopic murine model of lung cancer, provides methods for in vivo imaging and monitoring of tumor growth, and discusses the usefulness of this model for translational lung cancer research and the development of therapeutic strategies.

Original languageEnglish (US)
Article number14.27
JournalCurrent protocols in pharmacology / editorial board, S.J. Enna (editor-in-chief) ... [et al.]
Volume1
Issue numberSUPPL.62
DOIs
StatePublished - 2013

Fingerprint

Non-Small Cell Lung Carcinoma
Lung Neoplasms
Neoplasms
Therapeutics
Cause of Death
Radiotherapy
Survival Rate
Drug Therapy
Growth
Research

Keywords

  • Bioluminescent in vivo imaging
  • Non-small cell lung cancer
  • Orthotopic model

ASJC Scopus subject areas

  • Pharmacology

Cite this

@article{5757ed9b13c040bc82e091582d011556,
title = "Utility and applications of orthotopic models of human non-small cell lung cancer (NSCLC) for the evaluation of novel and emerging cancer therapeutics",
abstract = "Lung cancer is a leading cause of cancer deaths worldwide. Despite advances in chemotherapy, radiation therapy, and surgery, lung cancer continues to have a low 5-year survival rate, highlighting a dire need for more effective means of prevention, diagnosis, prognosis, and treatment. Mouse models that recapitulate the clinical features of advanced human lung cancer are critical for testing novel therapeutic approaches. This unit describes a highly reproducible, easy-to-establish orthotopic murine model of lung cancer, provides methods for in vivo imaging and monitoring of tumor growth, and discusses the usefulness of this model for translational lung cancer research and the development of therapeutic strategies.",
keywords = "Bioluminescent in vivo imaging, Non-small cell lung cancer, Orthotopic model",
author = "Verline Justilien and Fields, {Alan P}",
year = "2013",
doi = "10.1002/0471141755.ph1427s62",
language = "English (US)",
volume = "1",
journal = "Current Protocols in Pharmacology",
issn = "1934-8282",
publisher = "John Wiley and Sons Inc.",
number = "SUPPL.62",

}

TY - JOUR

T1 - Utility and applications of orthotopic models of human non-small cell lung cancer (NSCLC) for the evaluation of novel and emerging cancer therapeutics

AU - Justilien, Verline

AU - Fields, Alan P

PY - 2013

Y1 - 2013

N2 - Lung cancer is a leading cause of cancer deaths worldwide. Despite advances in chemotherapy, radiation therapy, and surgery, lung cancer continues to have a low 5-year survival rate, highlighting a dire need for more effective means of prevention, diagnosis, prognosis, and treatment. Mouse models that recapitulate the clinical features of advanced human lung cancer are critical for testing novel therapeutic approaches. This unit describes a highly reproducible, easy-to-establish orthotopic murine model of lung cancer, provides methods for in vivo imaging and monitoring of tumor growth, and discusses the usefulness of this model for translational lung cancer research and the development of therapeutic strategies.

AB - Lung cancer is a leading cause of cancer deaths worldwide. Despite advances in chemotherapy, radiation therapy, and surgery, lung cancer continues to have a low 5-year survival rate, highlighting a dire need for more effective means of prevention, diagnosis, prognosis, and treatment. Mouse models that recapitulate the clinical features of advanced human lung cancer are critical for testing novel therapeutic approaches. This unit describes a highly reproducible, easy-to-establish orthotopic murine model of lung cancer, provides methods for in vivo imaging and monitoring of tumor growth, and discusses the usefulness of this model for translational lung cancer research and the development of therapeutic strategies.

KW - Bioluminescent in vivo imaging

KW - Non-small cell lung cancer

KW - Orthotopic model

UR - http://www.scopus.com/inward/record.url?scp=84896350321&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896350321&partnerID=8YFLogxK

U2 - 10.1002/0471141755.ph1427s62

DO - 10.1002/0471141755.ph1427s62

M3 - Article

VL - 1

JO - Current Protocols in Pharmacology

JF - Current Protocols in Pharmacology

SN - 1934-8282

IS - SUPPL.62

M1 - 14.27

ER -