Utility and applications of orthotopic models of human non-small cell lung cancer (NSCLC) for the evaluation of novel and emerging cancer therapeutics.

Verline Justilien, Alan P. Fields

Research output: Contribution to journalArticle

Abstract

Lung cancer is a leading cause of cancer deaths worldwide. Despite advances in chemotherapy, radiation therapy, and surgery, lung cancer continues to have a low 5-year survival rate, highlighting a dire need for more effective means of prevention, diagnosis, prognosis, and treatment. Mouse models that recapitulate the clinical features of advanced human lung cancer are critical for testing novel therapeutic approaches. This unit describes a highly reproducible, easy-to-establish orthotopic murine model of lung cancer, provides methods for in vivo imaging and monitoring of tumor growth, and discusses the usefulness of this model for translational lung cancer research and the development of therapeutic strategies.

Original languageEnglish (US)
JournalCurrent protocols in pharmacology / editorial board, S.J. Enna (editor-in-chief) ... [et al.]
Volume62
StatePublished - 2013
Externally publishedYes

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Non-Small Cell Lung Carcinoma
Lung Neoplasms
Neoplasms
Therapeutics
Cause of Death
Radiotherapy
Survival Rate
Drug Therapy
Growth
Research

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "Lung cancer is a leading cause of cancer deaths worldwide. Despite advances in chemotherapy, radiation therapy, and surgery, lung cancer continues to have a low 5-year survival rate, highlighting a dire need for more effective means of prevention, diagnosis, prognosis, and treatment. Mouse models that recapitulate the clinical features of advanced human lung cancer are critical for testing novel therapeutic approaches. This unit describes a highly reproducible, easy-to-establish orthotopic murine model of lung cancer, provides methods for in vivo imaging and monitoring of tumor growth, and discusses the usefulness of this model for translational lung cancer research and the development of therapeutic strategies.",
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