Usual interstitial pneumonia and nonspecific interstitial pneumonia: Correlation between CT findings at the site of biopsy with pathological diagnoses

Hiromitsu Sumikawa, Takeshi Johkoh, Kiminori Fujimoto, Kazuya Ichikado, Thomas V. Colby, Junya Fukuoka, Hiroyuki Taniguchi, Yasuhiro Kondoh, Kensuke Kataoka, Masahiro Yanagawa, Mitsuhiro Koyama, Osamu Honda, Noriyuki Tomiyama

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objectives: The aim of this study was to correlate high-resolution CT (HRCT) findings at the site of biopsy with the whole lung CT and pathologic diagnoses in usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP). Methods: The study included 35 patients (25 UIP and 10 NSIP) diagnosed both pathologically and clinically. 81 surgical biopsy specimens (54 UIP, and 27 NSIP) and extracted areas corresponding to biopsy sites on HRCT were analyzed. CT interpretations were compared with pathological diagnoses in both extracted images and the whole lung. Concordant and discordant cases in multiple extracted images were divided and analyzed. Then the whole cases were categorized by including or not at least one UIP diagnosis of extracted images and evaluated. Results: The diagnoses in extracted sites significantly correlated with pathological diagnoses (p = 0.047). There were significant differences in the concordances of extracted images compared with the diagnosis of whole lung and pathology (p = 0.008, 0.003, respectively). All 7 cases that were not concordant were diagnosed as radiological UIP with whole lung CT. The cases with at least one UIP diagnosis of extracted CT images were diagnosed as UIP in pathology more frequently (18 in 25) (p = 0.007). Conclusions: Radiological UIP in whole CT had more frequently discordant diagnoses from multiple extracted images than NSIP. And there were more cases in pathological UIP that included at least one UIP diagnosis of extracted images compared with pathological NSIP.

Original languageEnglish (US)
Pages (from-to)2919-2924
Number of pages6
JournalEuropean Journal of Radiology
Volume81
Issue number10
DOIs
StatePublished - Oct 2012

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Idiopathic Pulmonary Fibrosis
Interstitial Lung Diseases
Biopsy
Lung
Pathology

Keywords

  • Computed tomography scanner
  • Idiopathic interstitial pneumonias
  • Idiopathic pulmonary fibrosis
  • Interstitial
  • Lung
  • Lung diseases
  • X-ray

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Usual interstitial pneumonia and nonspecific interstitial pneumonia : Correlation between CT findings at the site of biopsy with pathological diagnoses. / Sumikawa, Hiromitsu; Johkoh, Takeshi; Fujimoto, Kiminori; Ichikado, Kazuya; Colby, Thomas V.; Fukuoka, Junya; Taniguchi, Hiroyuki; Kondoh, Yasuhiro; Kataoka, Kensuke; Yanagawa, Masahiro; Koyama, Mitsuhiro; Honda, Osamu; Tomiyama, Noriyuki.

In: European Journal of Radiology, Vol. 81, No. 10, 10.2012, p. 2919-2924.

Research output: Contribution to journalArticle

Sumikawa, H, Johkoh, T, Fujimoto, K, Ichikado, K, Colby, TV, Fukuoka, J, Taniguchi, H, Kondoh, Y, Kataoka, K, Yanagawa, M, Koyama, M, Honda, O & Tomiyama, N 2012, 'Usual interstitial pneumonia and nonspecific interstitial pneumonia: Correlation between CT findings at the site of biopsy with pathological diagnoses', European Journal of Radiology, vol. 81, no. 10, pp. 2919-2924. https://doi.org/10.1016/j.ejrad.2011.11.018
Sumikawa, Hiromitsu ; Johkoh, Takeshi ; Fujimoto, Kiminori ; Ichikado, Kazuya ; Colby, Thomas V. ; Fukuoka, Junya ; Taniguchi, Hiroyuki ; Kondoh, Yasuhiro ; Kataoka, Kensuke ; Yanagawa, Masahiro ; Koyama, Mitsuhiro ; Honda, Osamu ; Tomiyama, Noriyuki. / Usual interstitial pneumonia and nonspecific interstitial pneumonia : Correlation between CT findings at the site of biopsy with pathological diagnoses. In: European Journal of Radiology. 2012 ; Vol. 81, No. 10. pp. 2919-2924.
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abstract = "Objectives: The aim of this study was to correlate high-resolution CT (HRCT) findings at the site of biopsy with the whole lung CT and pathologic diagnoses in usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP). Methods: The study included 35 patients (25 UIP and 10 NSIP) diagnosed both pathologically and clinically. 81 surgical biopsy specimens (54 UIP, and 27 NSIP) and extracted areas corresponding to biopsy sites on HRCT were analyzed. CT interpretations were compared with pathological diagnoses in both extracted images and the whole lung. Concordant and discordant cases in multiple extracted images were divided and analyzed. Then the whole cases were categorized by including or not at least one UIP diagnosis of extracted images and evaluated. Results: The diagnoses in extracted sites significantly correlated with pathological diagnoses (p = 0.047). There were significant differences in the concordances of extracted images compared with the diagnosis of whole lung and pathology (p = 0.008, 0.003, respectively). All 7 cases that were not concordant were diagnosed as radiological UIP with whole lung CT. The cases with at least one UIP diagnosis of extracted CT images were diagnosed as UIP in pathology more frequently (18 in 25) (p = 0.007). Conclusions: Radiological UIP in whole CT had more frequently discordant diagnoses from multiple extracted images than NSIP. And there were more cases in pathological UIP that included at least one UIP diagnosis of extracted images compared with pathological NSIP.",
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AU - Sumikawa, Hiromitsu

AU - Johkoh, Takeshi

AU - Fujimoto, Kiminori

AU - Ichikado, Kazuya

AU - Colby, Thomas V.

AU - Fukuoka, Junya

AU - Taniguchi, Hiroyuki

AU - Kondoh, Yasuhiro

AU - Kataoka, Kensuke

AU - Yanagawa, Masahiro

AU - Koyama, Mitsuhiro

AU - Honda, Osamu

AU - Tomiyama, Noriyuki

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N2 - Objectives: The aim of this study was to correlate high-resolution CT (HRCT) findings at the site of biopsy with the whole lung CT and pathologic diagnoses in usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP). Methods: The study included 35 patients (25 UIP and 10 NSIP) diagnosed both pathologically and clinically. 81 surgical biopsy specimens (54 UIP, and 27 NSIP) and extracted areas corresponding to biopsy sites on HRCT were analyzed. CT interpretations were compared with pathological diagnoses in both extracted images and the whole lung. Concordant and discordant cases in multiple extracted images were divided and analyzed. Then the whole cases were categorized by including or not at least one UIP diagnosis of extracted images and evaluated. Results: The diagnoses in extracted sites significantly correlated with pathological diagnoses (p = 0.047). There were significant differences in the concordances of extracted images compared with the diagnosis of whole lung and pathology (p = 0.008, 0.003, respectively). All 7 cases that were not concordant were diagnosed as radiological UIP with whole lung CT. The cases with at least one UIP diagnosis of extracted CT images were diagnosed as UIP in pathology more frequently (18 in 25) (p = 0.007). Conclusions: Radiological UIP in whole CT had more frequently discordant diagnoses from multiple extracted images than NSIP. And there were more cases in pathological UIP that included at least one UIP diagnosis of extracted images compared with pathological NSIP.

AB - Objectives: The aim of this study was to correlate high-resolution CT (HRCT) findings at the site of biopsy with the whole lung CT and pathologic diagnoses in usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP). Methods: The study included 35 patients (25 UIP and 10 NSIP) diagnosed both pathologically and clinically. 81 surgical biopsy specimens (54 UIP, and 27 NSIP) and extracted areas corresponding to biopsy sites on HRCT were analyzed. CT interpretations were compared with pathological diagnoses in both extracted images and the whole lung. Concordant and discordant cases in multiple extracted images were divided and analyzed. Then the whole cases were categorized by including or not at least one UIP diagnosis of extracted images and evaluated. Results: The diagnoses in extracted sites significantly correlated with pathological diagnoses (p = 0.047). There were significant differences in the concordances of extracted images compared with the diagnosis of whole lung and pathology (p = 0.008, 0.003, respectively). All 7 cases that were not concordant were diagnosed as radiological UIP with whole lung CT. The cases with at least one UIP diagnosis of extracted CT images were diagnosed as UIP in pathology more frequently (18 in 25) (p = 0.007). Conclusions: Radiological UIP in whole CT had more frequently discordant diagnoses from multiple extracted images than NSIP. And there were more cases in pathological UIP that included at least one UIP diagnosis of extracted images compared with pathological NSIP.

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