Usual interstitial pneumonia and non-specific interstitial pneumonia: Serial thin-section CT findings correlated with pulmonary function

Joo Jeong Yeon, Kyung Soo Lee, Nestor L. Müller, Pyo Chung Man, Jin Chung Myung, Joungho Han, Thomas V. Colby, Seonwoo Kim

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Objective: We wanted to demonstrate and compare the serial high-resolution CTs (HRCT) and the pulmonary function test (PFT) findings of the usual interstitial pneumonia (UIP) and the non-specific interstitial pneumonia (NSIP). Materials and Methods: The serial HRCT scans and the PFT results were retrospectively analysed and compared for 35 patients having UIP without significant honeycombing (UIP-w/o hc, < 5% of honeycombing at CT), 35 patients having UIP with honeycombing (UIP-w/i hc, ≥ 5% of honeycombing), and 25 patients with NSIP. The mortality rates were also compared. Follow-up CT scans were available in 75 patients (29 UIP-w/o hc patients, 22 UIP-w/i hc patients and 24 NSIP patients) and the follow-up periods ranged from 150 to 2,370 days. The initial and follow-up PFT data were available for 71 patients. Results: On the initial CT, significant differences were present between the UIP-w/i hc patients and both the UIP-w/o hc patients and the NSIP patients in the overall extent, ground-glass opacity (GGO) away from the reticulation, reticulation and honeycombing (all p < 0.05). Improvement was noticed in five (17%) of 29 UIP-w/o hc patients, none of 22 UIP-w/i hc patients, and 9 (37%) of 24 NSIP patients; deterioration was noted in six (21%) UIP-w/o hc patients, two (9%) UIP-w/i hc patients and three (13%) NSIP patients (p = 0.044 between UIP-w/o and UIP-w/i hc; p = 0.637 between UIP-w/o hc and NSIP; p = 0.007 between UIP-w/i hc and NSIP). The serial changes of the pulmonary function in the NSIP patients were different from those noted for the UIP-w/i hc and UIP-w/o hc patients (p = 0.440 between UIP-w/o and UIP-w/i hc; p = 0.022 between UIP-w/o hc and NSIP; p = 0.003 between UIP-w/i hc and NSIP). Five (14%) of the 35 patients with UIP-w/o hc, 16 (46%) of the 35 patients with UIP-w/i hc and three (12%) of the 25 patients with NSIP died (p = 0.002, comparison for the three groups). Conclusion: On CT, NSIP and UIP-w/o hc patients have similar patterns of parenchymal abnormalities and a similar likelihood of change in the extent of disease on follow-up. Patients with UIP-w/i hc have distinctive features and a worst prognosis.

Original languageEnglish (US)
Pages (from-to)143-152
Number of pages10
JournalKorean Journal of Radiology
Volume6
Issue number3
StatePublished - Jul 1 2005

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Keywords

  • Lung, CT
  • Lung, diseases
  • Lung, fibrosis
  • Lung, interstitial disease
  • Pneumonia, non-specific interstitial and fibrosis
  • Pneumonia, usual interstitial

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Yeon, J. J., Lee, K. S., Müller, N. L., Man, P. C., Myung, J. C., Han, J., Colby, T. V., & Kim, S. (2005). Usual interstitial pneumonia and non-specific interstitial pneumonia: Serial thin-section CT findings correlated with pulmonary function. Korean Journal of Radiology, 6(3), 143-152.