Using the Frontal Assessment Battery to identify executive function impairments in amyotrophic lateral sclerosis: A preliminary experience

Bjrn Oskarsson, Dianna Quan, Yvonne D. Rollins, Hans E. Neville, Steven P. Ringel, David B. Arciniegas

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Up to 50% of persons with amyotrophic lateral sclerosis (ALS) develop cognitive impairments, particularly of executive function (EF). The Frontal Assessment Battery (FAB) provides a method for rapid assessment of EF. We investigated the FAB as an assessment of cognitive impairment among 16 subjects with ALS, and evaluated their performance on the FAB and the Mini-Mental State Examination (MMSE). Raw FAB and MMSE scores were Z-transformed using published age- and education-based norms. FAB Z-scores were significantly lower than MMSE Z-scores (p<0.03). Eight subjects (50%) were impaired (Z ≤ -2) on the FAB while no subjects were impaired on the MMSE. MMSE and FAB scores did not vary as function of disease duration, laterality of onset, or Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) scores. Further study of the suitability of the FAB as a domain-specific screening measure of executive dysfunction for ALS is warranted.

Original languageEnglish (US)
Pages (from-to)244-247
Number of pages4
JournalAmyotrophic Lateral Sclerosis
Volume11
Issue number1-2
DOIs
StatePublished - Mar 11 2010

Keywords

  • ALS
  • Amyotrophic lateral sclerosis
  • Cognition disorders
  • Frontal lobe
  • Motor neuron disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Using the Frontal Assessment Battery to identify executive function impairments in amyotrophic lateral sclerosis: A preliminary experience'. Together they form a unique fingerprint.

  • Cite this