Using magnetic resonance elastography to assess the dynamic mechanical properties of cartilage

Orlando Lopez, Kimberly Amrami, Phillip Rossman, Richard Lorne Ehman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

This work explored the feasibility of using Magnetic Resonance Elastography (MRE) technology to enable in vitro quantification of dynamic mechanical behavior of cartilage through its thickness. A customized system for MRE of cartilage was designed to include components for adequate generation and detection of high frequency mechanical shear waves within small and stiff materials. The system included components for mechanical excitation, motion encoding, and imaging of small samples. Limitations in sensitivity to motion encoding of high frequency propagating mechanical waves using a whole body coil (i.e. G max = 2.2 G/cm) required the design of a local gradient coil system to achieve a gain in gradient strength of at least 5 times. The performance of the new system was tested using various cartilage-mimicking phantom materials. MRE of a stiff 5% agar gelatin phantom demonstrated gains in sensitivity to motion encoding of high frequency mechanical waves in cartilage like materials. MRE of fetal bovine cartilage samples yielded a distribution of shear stiffness within the thickness of the cartilage similar to values found in the literature, hence, suggesting the feasibility of using MRE to non-invasively and directly assess the dynamic mechanical properties of cartilage.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsA.A. Amini, A. Mandura
Pages51-61
Number of pages11
Volume5369
DOIs
StatePublished - 2004
EventMedical Imaging 2004: Physiology, Function, and Structure from Medical Images - San Diego, CA, United States
Duration: Feb 15 2004Feb 17 2004

Other

OtherMedical Imaging 2004: Physiology, Function, and Structure from Medical Images
CountryUnited States
CitySan Diego, CA
Period2/15/042/17/04

Fingerprint

cartilage
Cartilage
Magnetic resonance
magnetic resonance
mechanical properties
Mechanical waves
Mechanical properties
coding
coils
gradients
Shear waves
sensitivity
gelatins
S waves
stiffness
Stiffness
shear
Imaging techniques
excitation

Keywords

  • Cartilage
  • Cartilage mechanics
  • Elastography
  • Local gradient coil
  • Mechanical properties
  • MRE
  • Strong magnetic field gradient

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Lopez, O., Amrami, K., Rossman, P., & Ehman, R. L. (2004). Using magnetic resonance elastography to assess the dynamic mechanical properties of cartilage. In A. A. Amini, & A. Mandura (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 5369, pp. 51-61) https://doi.org/10.1117/12.533528

Using magnetic resonance elastography to assess the dynamic mechanical properties of cartilage. / Lopez, Orlando; Amrami, Kimberly; Rossman, Phillip; Ehman, Richard Lorne.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / A.A. Amini; A. Mandura. Vol. 5369 2004. p. 51-61.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lopez, O, Amrami, K, Rossman, P & Ehman, RL 2004, Using magnetic resonance elastography to assess the dynamic mechanical properties of cartilage. in AA Amini & A Mandura (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 5369, pp. 51-61, Medical Imaging 2004: Physiology, Function, and Structure from Medical Images, San Diego, CA, United States, 2/15/04. https://doi.org/10.1117/12.533528
Lopez O, Amrami K, Rossman P, Ehman RL. Using magnetic resonance elastography to assess the dynamic mechanical properties of cartilage. In Amini AA, Mandura A, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 5369. 2004. p. 51-61 https://doi.org/10.1117/12.533528
Lopez, Orlando ; Amrami, Kimberly ; Rossman, Phillip ; Ehman, Richard Lorne. / Using magnetic resonance elastography to assess the dynamic mechanical properties of cartilage. Proceedings of SPIE - The International Society for Optical Engineering. editor / A.A. Amini ; A. Mandura. Vol. 5369 2004. pp. 51-61
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