TY - GEN
T1 - Using EHR-Linked Biobank Data to Study Metformin Pharmacogenomics
AU - Breitenstein, Matthew K.
AU - Simon, Gyorgy
AU - Ryu, Euijung
AU - Armasu, Sebastian M.
AU - Weinshilboum, Richard M.
AU - Wang, Liewei
AU - Pathak, Jyotishman
N1 - Publisher Copyright:
© 2015 European Federation for Medical Informatics (EFMI).
PY - 2015
Y1 - 2015
N2 - Metformin is a commonly prescribed diabetes medication whose mechanism of action is poorly understood. In this study we utilized EHR-linked biobank data to elucidate the impact of genomic variation on glycemic response to metformin. Our study found significant gene- and SNP-level associations within the beta-2 subunit of the heterotrimeric adenosine monophosphate-activated protein kinase complex. Using EHR phenotypes where were able to add additional clarity to ongoing metformin pharmacogenomic dialogue.
AB - Metformin is a commonly prescribed diabetes medication whose mechanism of action is poorly understood. In this study we utilized EHR-linked biobank data to elucidate the impact of genomic variation on glycemic response to metformin. Our study found significant gene- and SNP-level associations within the beta-2 subunit of the heterotrimeric adenosine monophosphate-activated protein kinase complex. Using EHR phenotypes where were able to add additional clarity to ongoing metformin pharmacogenomic dialogue.
KW - Biobank
KW - Electronic Health Records
KW - Metformin
KW - Pharmacogenomics
KW - Type 2 Diabetes Mellitus
UR - http://www.scopus.com/inward/record.url?scp=84937485223&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84937485223&partnerID=8YFLogxK
U2 - 10.3233/978-1-61499-512-8-914
DO - 10.3233/978-1-61499-512-8-914
M3 - Conference contribution
C2 - 25991289
AN - SCOPUS:84937485223
T3 - Studies in Health Technology and Informatics
SP - 914
EP - 918
BT - Digital Healthcare Empowering Europeans - Proceedings of MIE 2015
A2 - Cornet, Ronald
A2 - Stoicu-Tivadar, Lacramioara
A2 - Cornet, Ronald
A2 - Parra Calderon, Carlos Luis
A2 - Andersen, Stig Kjaer
A2 - Horbst, Alexander
A2 - Hercigonja-Szekeres, Mira
PB - IOS Press
T2 - 26th Medical Informatics in Europe Conference, MIE 2015
Y2 - 27 May 2015 through 29 May 2015
ER -