Usefulness of left ventricular mass in predicting recovery of left ventricular systolic function in patients with symptomatic idiopathic dilated cardiomyopathy

Tasneem Zehra Naqvi, Rishi K. Goel, James S. Forrester, Robert M. Davidson, Robert J. Siegel

Research output: Contribution to journalArticle

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Abstract

Prognosis of idiopathic dilated cardiomyopathy (IDC) is variable. We determined the prognostic value of left ventricular (LV) mass and systolic and diastolic function in patients with IDC of <12 months duration. Clinical and echocardiographic assessment was performed at baseline and at 8 ± 6 months follow-up in 25 patients (47 ± 13 years) with IDC and an LV ejection fraction (LVEF1) of <40% (22 ± 7%). Based on a follow-up LVEF (LVEF2) of < or >40%, patients were divided into unimproved (n = 13, LVEF2 = 21 ± 9%) and improved groups (n = 12, LVEF2 = 51 ± 11%). There was no difference in the LVEF1 (22 ± 8% vs 22 ± 6%), LV end-systolic (5.7 ± 0.8 vs 5.8 ± 0.9 cm) or end-diastolic (6.5 ± 0.6 vs 6.6 ± 0.9 cm) dimension, wall stress (102 ± 26 vs 99 ± 28 g/cm2), end-systolic (1.7 ± 0.3 vs 1.8 ± 0.2) or end-diastolic (1.7 ± 0.3 vs 1.6 ± 0.1) sphericity, dp/dt (582 ± 163 vs 678 ± 222 mm Hg/s), or right ventricular fractional shortening (20 ± 9% vs 27 ± 7%, p = 0.06) in unimproved and improved groups. LV mass was lower (1.00 ± 0.21 vs 1.38 ± 0.27 g/ml, p = 0007) and mitral inflow E-wave deceleration time shorter (97 ± 42 vs 164 ± 58 ms, p = 0007) in the unimproved versus the improved group. On Pearson correlation analysis, LV mass (r = 0.62, p = 0.001), deceleration time (r = 0.68, p = 0.0002), wall motion score index (r = -0.47, p = 02), and dp/dt (r = 0.52, p = 03) were the significant predictors of LVEF2. There was correlation between LV mass (grams per milliliter) and deceleration time (r = 0.61, p = 0.001). During follow-up, death occurred in 1, and readmission for worsening heart failure in 4 patients in the unimproved group versus no hospitalization in the improved group. Thus, in patients with recent onset IDC, LV mass and diastolic function determine late outcome.

Original languageEnglish (US)
Pages (from-to)624-629
Number of pages6
JournalAmerican Journal of Cardiology
Volume85
Issue number5
StatePublished - 2000
Externally publishedYes

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Dilated Cardiomyopathy
Left Ventricular Function
Deceleration
Hospitalization
Heart Failure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Usefulness of left ventricular mass in predicting recovery of left ventricular systolic function in patients with symptomatic idiopathic dilated cardiomyopathy. / Naqvi, Tasneem Zehra; Goel, Rishi K.; Forrester, James S.; Davidson, Robert M.; Siegel, Robert J.

In: American Journal of Cardiology, Vol. 85, No. 5, 2000, p. 624-629.

Research output: Contribution to journalArticle

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abstract = "Prognosis of idiopathic dilated cardiomyopathy (IDC) is variable. We determined the prognostic value of left ventricular (LV) mass and systolic and diastolic function in patients with IDC of <12 months duration. Clinical and echocardiographic assessment was performed at baseline and at 8 ± 6 months follow-up in 25 patients (47 ± 13 years) with IDC and an LV ejection fraction (LVEF1) of <40{\%} (22 ± 7{\%}). Based on a follow-up LVEF (LVEF2) of < or >40{\%}, patients were divided into unimproved (n = 13, LVEF2 = 21 ± 9{\%}) and improved groups (n = 12, LVEF2 = 51 ± 11{\%}). There was no difference in the LVEF1 (22 ± 8{\%} vs 22 ± 6{\%}), LV end-systolic (5.7 ± 0.8 vs 5.8 ± 0.9 cm) or end-diastolic (6.5 ± 0.6 vs 6.6 ± 0.9 cm) dimension, wall stress (102 ± 26 vs 99 ± 28 g/cm2), end-systolic (1.7 ± 0.3 vs 1.8 ± 0.2) or end-diastolic (1.7 ± 0.3 vs 1.6 ± 0.1) sphericity, dp/dt (582 ± 163 vs 678 ± 222 mm Hg/s), or right ventricular fractional shortening (20 ± 9{\%} vs 27 ± 7{\%}, p = 0.06) in unimproved and improved groups. LV mass was lower (1.00 ± 0.21 vs 1.38 ± 0.27 g/ml, p = 0007) and mitral inflow E-wave deceleration time shorter (97 ± 42 vs 164 ± 58 ms, p = 0007) in the unimproved versus the improved group. On Pearson correlation analysis, LV mass (r = 0.62, p = 0.001), deceleration time (r = 0.68, p = 0.0002), wall motion score index (r = -0.47, p = 02), and dp/dt (r = 0.52, p = 03) were the significant predictors of LVEF2. There was correlation between LV mass (grams per milliliter) and deceleration time (r = 0.61, p = 0.001). During follow-up, death occurred in 1, and readmission for worsening heart failure in 4 patients in the unimproved group versus no hospitalization in the improved group. Thus, in patients with recent onset IDC, LV mass and diastolic function determine late outcome.",
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AU - Siegel, Robert J.

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