Usefulness of left atrial volume in predicting first congestive heart failure in patients <65 years of age with well-preserved left ventricular systolic function

Yasuhiko Takemoto, Marion E. Barnes, James B. Seward, Steven Jay Lester, Christopher A. Appleton, Bernard J. Gersh, Kent R Bailey, Teresa S M Tsang

Research output: Contribution to journalArticle

216 Citations (Scopus)

Abstract

Left atrial (LA) volume is a barometer of diastolic dysfunction. Whether it predicts congestive heart failure (CHF) in patients with preserved left ventricular (LV) systolic function is not known. Olmsted County, Minnesota, residents aged <65 years referred for transthoracic echocardiography from 1990 to 1998, who were in sinus rhythm without a history of CHF were followed in the medical records to 2003 (mean follow-up duration 4.3 ± 2.7 years). Of the 1,495 patients identified, 1,375 (92%) with LV ejection fractions <50% (mean age 75 ± 7 years; 59% women) constituted the study population, 138 (10%) of whom developed CHF. Baseline LA volume <32 ml/m2 was an independent predictor of first CHF (p <0.001). Of the 138 patients who had first CHF, ejection fractions were assessed within 4 weeks of diagnosis in 98 subjects, 74 (76%) of whom had ejection fractions remaining at <50%, with a mean increase in LA volume of 8 ± 10 ml/m2 (p <0.001) from baseline. The age-adjusted CHF-free survival rates for LA volume tertiles (<28, 28 to ≤37, and >37 ml/m2) were 95%, 91%, and 83%, respectively (p <0.001). In conclusion, LA volume independently predicted first CHF in an elderly cohort with well-preserved LV systolic function.

Original languageEnglish (US)
Pages (from-to)832-836
Number of pages5
JournalAmerican Journal of Cardiology
Volume96
Issue number6
DOIs
StatePublished - Sep 15 2005

Fingerprint

Left Ventricular Function
Heart Failure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Usefulness of left atrial volume in predicting first congestive heart failure in patients <65 years of age with well-preserved left ventricular systolic function. / Takemoto, Yasuhiko; Barnes, Marion E.; Seward, James B.; Lester, Steven Jay; Appleton, Christopher A.; Gersh, Bernard J.; Bailey, Kent R; Tsang, Teresa S M.

In: American Journal of Cardiology, Vol. 96, No. 6, 15.09.2005, p. 832-836.

Research output: Contribution to journalArticle

Takemoto, Yasuhiko ; Barnes, Marion E. ; Seward, James B. ; Lester, Steven Jay ; Appleton, Christopher A. ; Gersh, Bernard J. ; Bailey, Kent R ; Tsang, Teresa S M. / Usefulness of left atrial volume in predicting first congestive heart failure in patients <65 years of age with well-preserved left ventricular systolic function. In: American Journal of Cardiology. 2005 ; Vol. 96, No. 6. pp. 832-836.
@article{93437fd3afca44da9ea2773e9322c921,
title = "Usefulness of left atrial volume in predicting first congestive heart failure in patients <65 years of age with well-preserved left ventricular systolic function",
abstract = "Left atrial (LA) volume is a barometer of diastolic dysfunction. Whether it predicts congestive heart failure (CHF) in patients with preserved left ventricular (LV) systolic function is not known. Olmsted County, Minnesota, residents aged <65 years referred for transthoracic echocardiography from 1990 to 1998, who were in sinus rhythm without a history of CHF were followed in the medical records to 2003 (mean follow-up duration 4.3 ± 2.7 years). Of the 1,495 patients identified, 1,375 (92{\%}) with LV ejection fractions <50{\%} (mean age 75 ± 7 years; 59{\%} women) constituted the study population, 138 (10{\%}) of whom developed CHF. Baseline LA volume <32 ml/m2 was an independent predictor of first CHF (p <0.001). Of the 138 patients who had first CHF, ejection fractions were assessed within 4 weeks of diagnosis in 98 subjects, 74 (76{\%}) of whom had ejection fractions remaining at <50{\%}, with a mean increase in LA volume of 8 ± 10 ml/m2 (p <0.001) from baseline. The age-adjusted CHF-free survival rates for LA volume tertiles (<28, 28 to ≤37, and >37 ml/m2) were 95{\%}, 91{\%}, and 83{\%}, respectively (p <0.001). In conclusion, LA volume independently predicted first CHF in an elderly cohort with well-preserved LV systolic function.",
author = "Yasuhiko Takemoto and Barnes, {Marion E.} and Seward, {James B.} and Lester, {Steven Jay} and Appleton, {Christopher A.} and Gersh, {Bernard J.} and Bailey, {Kent R} and Tsang, {Teresa S M}",
year = "2005",
month = "9",
day = "15",
doi = "10.1016/j.amjcard.2005.05.031",
language = "English (US)",
volume = "96",
pages = "832--836",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Usefulness of left atrial volume in predicting first congestive heart failure in patients <65 years of age with well-preserved left ventricular systolic function

AU - Takemoto, Yasuhiko

AU - Barnes, Marion E.

AU - Seward, James B.

AU - Lester, Steven Jay

AU - Appleton, Christopher A.

AU - Gersh, Bernard J.

AU - Bailey, Kent R

AU - Tsang, Teresa S M

PY - 2005/9/15

Y1 - 2005/9/15

N2 - Left atrial (LA) volume is a barometer of diastolic dysfunction. Whether it predicts congestive heart failure (CHF) in patients with preserved left ventricular (LV) systolic function is not known. Olmsted County, Minnesota, residents aged <65 years referred for transthoracic echocardiography from 1990 to 1998, who were in sinus rhythm without a history of CHF were followed in the medical records to 2003 (mean follow-up duration 4.3 ± 2.7 years). Of the 1,495 patients identified, 1,375 (92%) with LV ejection fractions <50% (mean age 75 ± 7 years; 59% women) constituted the study population, 138 (10%) of whom developed CHF. Baseline LA volume <32 ml/m2 was an independent predictor of first CHF (p <0.001). Of the 138 patients who had first CHF, ejection fractions were assessed within 4 weeks of diagnosis in 98 subjects, 74 (76%) of whom had ejection fractions remaining at <50%, with a mean increase in LA volume of 8 ± 10 ml/m2 (p <0.001) from baseline. The age-adjusted CHF-free survival rates for LA volume tertiles (<28, 28 to ≤37, and >37 ml/m2) were 95%, 91%, and 83%, respectively (p <0.001). In conclusion, LA volume independently predicted first CHF in an elderly cohort with well-preserved LV systolic function.

AB - Left atrial (LA) volume is a barometer of diastolic dysfunction. Whether it predicts congestive heart failure (CHF) in patients with preserved left ventricular (LV) systolic function is not known. Olmsted County, Minnesota, residents aged <65 years referred for transthoracic echocardiography from 1990 to 1998, who were in sinus rhythm without a history of CHF were followed in the medical records to 2003 (mean follow-up duration 4.3 ± 2.7 years). Of the 1,495 patients identified, 1,375 (92%) with LV ejection fractions <50% (mean age 75 ± 7 years; 59% women) constituted the study population, 138 (10%) of whom developed CHF. Baseline LA volume <32 ml/m2 was an independent predictor of first CHF (p <0.001). Of the 138 patients who had first CHF, ejection fractions were assessed within 4 weeks of diagnosis in 98 subjects, 74 (76%) of whom had ejection fractions remaining at <50%, with a mean increase in LA volume of 8 ± 10 ml/m2 (p <0.001) from baseline. The age-adjusted CHF-free survival rates for LA volume tertiles (<28, 28 to ≤37, and >37 ml/m2) were 95%, 91%, and 83%, respectively (p <0.001). In conclusion, LA volume independently predicted first CHF in an elderly cohort with well-preserved LV systolic function.

UR - http://www.scopus.com/inward/record.url?scp=24944570134&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24944570134&partnerID=8YFLogxK

U2 - 10.1016/j.amjcard.2005.05.031

DO - 10.1016/j.amjcard.2005.05.031

M3 - Article

C2 - 16169372

AN - SCOPUS:24944570134

VL - 96

SP - 832

EP - 836

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 6

ER -