Usefulness of High-Density Lipoprotein Cholesterol to Predict Survival in Pulmonary Arterial Hypertension

Carolyn M. Larsen, Robert B. McCully, Joseph G. Murphy, Sudhir S. Kushwaha, Robert Frantz, Garvan M Kane

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

It has been suggested that lipoprotein abnormalities may contribute to the pulmonary arteriolar dysfunction observed in pulmonary arterial hypertension (PAH). High-density lipoprotein cholesterol (HDL) has vasodilatory, anti-inflammatory, and endothelial protective properties. We hypothesized that a higher serum HDL level may be advantageous for survival in PAH and that the serum HDL level at diagnosis would be an independent predictor of survival in PAH and be additive to previously validated predictors of survival. This study included all patients with PAH seen at the Mayo Clinic Pulmonary Hypertension Clinic from January 1, 1995, to December 31, 2009, who had a baseline HDL measurement. Mortality was analyzed over 5 years using the Kaplan-Meier method. Univariate and multivariable Cox proportional hazards ratios were calculated to evaluate the relation between baseline HDL level and survival. HDL levels were available for 227 patients. Higher HDL levels were associated with significantly lower mortality. Patients with an HDL >54 mg/dl at diagnosis had a 5-year survival of 59%. By comparison those with an HDL <34 mg/dl had a 5-year survival of 30%. On multivariate analysis, higher HDL was associated with an age-adjusted risk ratio for death of 0.78 (CI 0.67 to 0.91; p <0.01) per 10 mg/dl increase. In conclusion, HDL was an independent predictor of survival in PAH.

Original languageEnglish (US)
Pages (from-to)292-297
Number of pages6
JournalAmerican Journal of Cardiology
Volume118
Issue number2
DOIs
StatePublished - Jul 15 2016

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Pulmonary Hypertension
HDL Cholesterol
Survival
Mortality
Serum
Lipoproteins
Anti-Inflammatory Agents
Multivariate Analysis
Odds Ratio
Lung

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Usefulness of High-Density Lipoprotein Cholesterol to Predict Survival in Pulmonary Arterial Hypertension. / Larsen, Carolyn M.; McCully, Robert B.; Murphy, Joseph G.; Kushwaha, Sudhir S.; Frantz, Robert; Kane, Garvan M.

In: American Journal of Cardiology, Vol. 118, No. 2, 15.07.2016, p. 292-297.

Research output: Contribution to journalArticle

Larsen, Carolyn M. ; McCully, Robert B. ; Murphy, Joseph G. ; Kushwaha, Sudhir S. ; Frantz, Robert ; Kane, Garvan M. / Usefulness of High-Density Lipoprotein Cholesterol to Predict Survival in Pulmonary Arterial Hypertension. In: American Journal of Cardiology. 2016 ; Vol. 118, No. 2. pp. 292-297.
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