Usefulness of Detectable Levels of Troponin, Below the 99th Percentile of the Normal Range, as a Clue to the Presence of Underlying Coronary Artery Disease

Olaf Schulz, Claudia Paul-Walter, Matthias Lehmann, Klaus Abraham, Gunnar Berghöfer, Ingolf Schimke, Allan S. Jaffe

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

The aim of the study was to evaluate whether markers of myocardial injury and ischemia are helpful in detecting coronary artery disease (CAD) in patients with stable angina. Venous blood was obtained before and after a bicycle exercise test in 47 outpatients with suspected CAD for measurement of cardiac troponin I (cTnI), heart-type fatty acid binding protein, and glycogen phosphorylase BB. Patients with a coronary artery stenosis ≥70% in diameter (n = 33) were compared with patients with coronary narrowing <50% (controls, n = 14). None of the markers increased after bicycle exercise testing. cTnI measured before and after exercise was higher in the CAD group than in controls (p <0.001). The area under the curve for diagnosis was greater when the cTnI value was detectable than with stress testing alone. In conclusion, baseline cTnI was of value in detecting CAD and also during follow-up in predicting the need for further revascularization.

Original languageEnglish (US)
Pages (from-to)764-769
Number of pages6
JournalAmerican Journal of Cardiology
Volume100
Issue number5
DOIs
StatePublished - Sep 1 2007

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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