@article{f4dd6aa8f33e44fe99dc6106eed3382f,
title = "Usefulness of asthma predictive index in ascertaining asthma status of children using medical records: An explorative study",
abstract = "Background: Frequent wheezing in original asthma predictive index (API) was defined by parental report of recurrent wheezing within 1 year during the first 3 years of life. The nature of frequent wheezing in children, particularly aged over 3 years, has not been studied. We aimed to assess the frequency and interval of wheezing to define frequent wheezing in ascertaining asthma for children using medical records. Methods: Among children who participated in a previous study (n = 427), all wheezing episodes documented in medical records were collected for children who had ≥2 wheezing episodes PLUS met one major criterion or two minor criteria of API. We compared the distribution of known risk factors for asthma between subjects having two consecutive wheezing episodes with shorter interval (≤1 year) compared to those with longer interval (1 to 3 years). Results: A total of 62 children met API at median age of 2.3 years. During follow-up period (median age: 11.3 years), a total of 198 wheezing episodes were observed. 81% of wheezing intervals were within 3 years from the earlier wheezing episode, including 60% within 1 year. Children who met API based on 1-year interval (n = 40) vs 1- to 3-year interval (n = 13) appeared to be similar in regard to the known risk factors for asthma. Conclusions: Our exploratory study finding suggests that children who had frequent wheezing episodes with longer interval (<3 years) need to be considered to be determined as asthma cases when API is applied to retrospective medical records. Prospective studies with a larger sample size need to replicate this finding.",
keywords = "asthma predictive index, heterogeneity, medical records, retrospective studies, wheezing",
author = "Wi, {C. I.} and Krusemark, {E. A.} and G. Voge and S. Sohn and H. Liu and E. Ryu and Park, {M. A.} and Castro-Rodriguez, {J. A.} and Juhn, {Y. J.}",
note = "Funding Information: Funding information This was supported by NIH-funded R01 grant “Asthma Ascertainment and Characterization through Electronic Health Records” (R01 HL126667). Also, this study was made possible using the resources of the Rochester Epidemiology Project, which is supported by the National Institute on Aging of the National Institutes of Health under Award Number R01AG034676. The funding agency was not involved in the design and conduct of the study, in the collection, analysis, and interpretation of the data, and in the preparation, review, or approval of the manuscript. The authors had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. This study was approved by the Institutional Review Board for Human Subject Research at the Mayo Clinic and the Olmsted Medical Center. We thank the original project staff and Mrs. Kelly Okeson for her administrative assistance. This was supported by NIH-funded R01 grant (R01 HL126667). Funding Information: We thank the original project staff and Mrs. Kelly Okeson for her administrative assistance. This was supported by NIH-funded R01 grant (R01 HL126667). Funding Information: This was supported by NIH-funded R01 grant “Asthma Ascertainment and Characterization through Electronic Health Records” (R01 HL126667). Also, this study was made possible using the resources of the Rochester Epidemiology Project, which is supported by the National Institute on Aging of the National Institutes of Health under Award Number R01AG034676. The funding agency was not involved in the design and conduct of the study, in the collection, analysis, and interpretation of the data, and in the preparation, review, or approval of the manuscript. The authors had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. This study was approved by the Institutional Review Board for Human Subject Research at the Mayo Clinic and the Olmsted Medical Center. Publisher Copyright: {\textcopyright} 2018 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.",
year = "2018",
month = jun,
doi = "10.1111/all.13403",
language = "English (US)",
volume = "73",
pages = "1276--1283",
journal = "Acta Allergologica",
issn = "0105-4538",
publisher = "Wiley-Blackwell",
number = "6",
}