Use of volumetric laser endomicroscopy for determining candidates for endoscopic therapy in superficial esophageal squamous cell carcinoma

Arvind J. Trindade, Petros C. Benias, Sumant Inamdar, Cathy Fan, Amrita Sethi, Norio Fukami, Allon Kahn, Michel Kahaleh, Iman Andalib, Divyesh V. Sejpal, Arvind Rishi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Accurate staging of superficial esophageal squamous cell cancer (ESCC) for endoscopic therapy is challenging. Optical coherence tomography (OCT) has been shown to be superior to high-resolution endoscopic ultrasound (EUS). Volumetric Laser Endomicroscopy (VLE), a second-generation OCT, has recently become commercially available. Objective: To assess if VLE can determine which patients with superficial ESSC can undergo endoscopic therapy. Methods: This is a multi-center retrospective study. Patients were included if (a) they had visible ESCC, (b) they underwent VLE and EUS for staging, and c) if superficial disease was suspected then endoscopic resection had to be performed to have accurate histology to compare the VLE scan to. VLE scans were then compared to the gold standard: histology for superficial disease and EUS for disease T1b and greater. Results: Seventeen patients were included with the following disease: squamous intraepithelial neoplasia (4 patients), T1a disease (6 patients), T1b (2 patients), T2 disease (2 patients) and T3 disease (3 patients). VLE was able to distinguish superficial disease, defined as disease limited up to the lamina propria, from non-superficial disease in all cases. Conclusions: VLE may be able to determine which ESCC patients are candidates for endoscopic therapy. Prospective studies are needed to confirm this.

Original languageEnglish (US)
Pages (from-to)838-845
Number of pages8
JournalUnited European Gastroenterology Journal
Volume6
Issue number6
DOIs
StatePublished - Jul 1 2018

Fingerprint

Lasers
Squamous Cell Neoplasms
Esophageal Neoplasms
Therapeutics
Optical Coherence Tomography
Histology
Esophageal Squamous Cell Carcinoma
Mucous Membrane
Retrospective Studies
Prospective Studies
Neoplasms

Keywords

  • advanced imaging
  • cancer
  • Esophagus
  • staging
  • volumetric laser endomicroscopy

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

Cite this

Use of volumetric laser endomicroscopy for determining candidates for endoscopic therapy in superficial esophageal squamous cell carcinoma. / Trindade, Arvind J.; Benias, Petros C.; Inamdar, Sumant; Fan, Cathy; Sethi, Amrita; Fukami, Norio; Kahn, Allon; Kahaleh, Michel; Andalib, Iman; Sejpal, Divyesh V.; Rishi, Arvind.

In: United European Gastroenterology Journal, Vol. 6, No. 6, 01.07.2018, p. 838-845.

Research output: Contribution to journalArticle

Trindade, Arvind J. ; Benias, Petros C. ; Inamdar, Sumant ; Fan, Cathy ; Sethi, Amrita ; Fukami, Norio ; Kahn, Allon ; Kahaleh, Michel ; Andalib, Iman ; Sejpal, Divyesh V. ; Rishi, Arvind. / Use of volumetric laser endomicroscopy for determining candidates for endoscopic therapy in superficial esophageal squamous cell carcinoma. In: United European Gastroenterology Journal. 2018 ; Vol. 6, No. 6. pp. 838-845.
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