Use of the syrian hamster as a new model of ebola virus disease and other viral hemorrhagic fevers

Victoria Wahl-Jensen, Laura Bollinger, David Safronetz, Fabian De Kok-Mercado, Dana P. Scott, Hideki Ebihara

Research output: Contribution to journalReview article

37 Scopus citations

Abstract

Historically, mice and guinea pigs have been the rodent models of choice for therapeutic and prophylactic countermeasure testing against Ebola virus disease (EVD). Recently, hamsters have emerged as a novel animal model for the in vivo study of EVD. In this review, we discuss the history of the hamster as a research laboratory animal, as well as current benefits and challenges of this model. Availability of immunological reagents is addressed. Salient features of EVD in hamsters, including relevant pathology and coagulation parameters, are compared directly with the mouse, guinea pig and nonhuman primate models.

Original languageEnglish (US)
Pages (from-to)3754-3784
Number of pages31
JournalViruses
Volume4
Issue number12
DOIs
StatePublished - Dec 1 2012

Keywords

  • Ebola
  • Filovirus
  • Hamster model
  • Pathogenesis
  • Rodent model

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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    Wahl-Jensen, V., Bollinger, L., Safronetz, D., De Kok-Mercado, F., Scott, D. P., & Ebihara, H. (2012). Use of the syrian hamster as a new model of ebola virus disease and other viral hemorrhagic fevers. Viruses, 4(12), 3754-3784. https://doi.org/10.3390/v4123754