Use of the syrian hamster as a new model of ebola virus disease and other viral hemorrhagic fevers

Victoria Wahl-Jensen, Laura Bollinger, David Safronetz, Fabian De Kok-Mercado, Dana P. Scott, Hideki Ebihara

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

Historically, mice and guinea pigs have been the rodent models of choice for therapeutic and prophylactic countermeasure testing against Ebola virus disease (EVD). Recently, hamsters have emerged as a novel animal model for the in vivo study of EVD. In this review, we discuss the history of the hamster as a research laboratory animal, as well as current benefits and challenges of this model. Availability of immunological reagents is addressed. Salient features of EVD in hamsters, including relevant pathology and coagulation parameters, are compared directly with the mouse, guinea pig and nonhuman primate models.

Original languageEnglish (US)
Pages (from-to)3754-3784
Number of pages31
JournalViruses
Volume4
Issue number12
DOIs
StatePublished - Dec 1 2012
Externally publishedYes

Fingerprint

Ebola Hemorrhagic Fever
Viral Hemorrhagic Fevers
Mesocricetus
Cricetinae
Guinea Pigs
Laboratory Animals
Primates
Rodentia
Animal Models
History
Pathology
Research
Therapeutics

Keywords

  • Ebola
  • Filovirus
  • Hamster model
  • Pathogenesis
  • Rodent model

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

Wahl-Jensen, V., Bollinger, L., Safronetz, D., De Kok-Mercado, F., Scott, D. P., & Ebihara, H. (2012). Use of the syrian hamster as a new model of ebola virus disease and other viral hemorrhagic fevers. Viruses, 4(12), 3754-3784. https://doi.org/10.3390/v4123754

Use of the syrian hamster as a new model of ebola virus disease and other viral hemorrhagic fevers. / Wahl-Jensen, Victoria; Bollinger, Laura; Safronetz, David; De Kok-Mercado, Fabian; Scott, Dana P.; Ebihara, Hideki.

In: Viruses, Vol. 4, No. 12, 01.12.2012, p. 3754-3784.

Research output: Contribution to journalReview article

Wahl-Jensen, V, Bollinger, L, Safronetz, D, De Kok-Mercado, F, Scott, DP & Ebihara, H 2012, 'Use of the syrian hamster as a new model of ebola virus disease and other viral hemorrhagic fevers', Viruses, vol. 4, no. 12, pp. 3754-3784. https://doi.org/10.3390/v4123754
Wahl-Jensen V, Bollinger L, Safronetz D, De Kok-Mercado F, Scott DP, Ebihara H. Use of the syrian hamster as a new model of ebola virus disease and other viral hemorrhagic fevers. Viruses. 2012 Dec 1;4(12):3754-3784. https://doi.org/10.3390/v4123754
Wahl-Jensen, Victoria ; Bollinger, Laura ; Safronetz, David ; De Kok-Mercado, Fabian ; Scott, Dana P. ; Ebihara, Hideki. / Use of the syrian hamster as a new model of ebola virus disease and other viral hemorrhagic fevers. In: Viruses. 2012 ; Vol. 4, No. 12. pp. 3754-3784.
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