TY - CHAP
T1 - Use of the rat as a model in regenerative medicine
AU - Scholz, Jodi A.
AU - Ramos, Carlos Cuellar
AU - VanLith, Caitlin J.
AU - De La Vega, Rodolfo E.
AU - Boschen, Suelen Lucio
AU - Evans, Christopher H.
AU - Hickey, Raymond D.
N1 - Publisher Copyright:
© 2020 Elsevier Inc. All rights reserved.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Regenerative medicine is a branch of medicine aimed at the repair, replacement, and functional restoration of tissues or organs that have been damaged due to disease, injury, or congenital defects. Specific therapeutic strategies involve the use of stem cells, tissue engineering, medical devices, and/or creation of artificial organs. Due to their size, ease of handling, relatively low cost, and similar anatomy and physiology to humans, rats are an ideal model to study regenerative-based therapies for the repair and treatment of a wide variety of diseases or injuries, most notably those affecting the liver, heart, bone, and central nervous system. This chapter provides an overview of rat models used to investigate regenerative medicine strategies and how the laboratory rat has contributed to progress in this exciting and rapidly growing field.
AB - Regenerative medicine is a branch of medicine aimed at the repair, replacement, and functional restoration of tissues or organs that have been damaged due to disease, injury, or congenital defects. Specific therapeutic strategies involve the use of stem cells, tissue engineering, medical devices, and/or creation of artificial organs. Due to their size, ease of handling, relatively low cost, and similar anatomy and physiology to humans, rats are an ideal model to study regenerative-based therapies for the repair and treatment of a wide variety of diseases or injuries, most notably those affecting the liver, heart, bone, and central nervous system. This chapter provides an overview of rat models used to investigate regenerative medicine strategies and how the laboratory rat has contributed to progress in this exciting and rapidly growing field.
KW - Bone regeneration
KW - Cardiac regeneration
KW - Liver regeneration
KW - Neuromodulation
KW - Parkinson’s disease
KW - Rat model
KW - Regenerative medicine
KW - Spinal cord regeneration
KW - Stem cells
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=85094568019&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85094568019&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-814338-4.00030-1
DO - 10.1016/B978-0-12-814338-4.00030-1
M3 - Chapter
AN - SCOPUS:85094568019
SP - 1077
EP - 1105
BT - The Laboratory Rat
PB - Elsevier
ER -