Use of the rat as a model in regenerative medicine

Jodi A. Scholz, Carlos Cuellar Ramos, Caitlin J. VanLith, Rodolfo E. De La Vega, Suelen Lucio Boschen, Christopher H. Evans, Raymond D. Hickey

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Regenerative medicine is a branch of medicine aimed at the repair, replacement, and functional restoration of tissues or organs that have been damaged due to disease, injury, or congenital defects. Specific therapeutic strategies involve the use of stem cells, tissue engineering, medical devices, and/or creation of artificial organs. Due to their size, ease of handling, relatively low cost, and similar anatomy and physiology to humans, rats are an ideal model to study regenerative-based therapies for the repair and treatment of a wide variety of diseases or injuries, most notably those affecting the liver, heart, bone, and central nervous system. This chapter provides an overview of rat models used to investigate regenerative medicine strategies and how the laboratory rat has contributed to progress in this exciting and rapidly growing field.

Original languageEnglish (US)
Title of host publicationThe Laboratory Rat
PublisherElsevier
Pages1077-1105
Number of pages29
ISBN (Electronic)9780128143384
DOIs
StatePublished - Jan 1 2019

Keywords

  • Bone regeneration
  • Cardiac regeneration
  • Liver regeneration
  • Neuromodulation
  • Parkinson’s disease
  • Rat model
  • Regenerative medicine
  • Spinal cord regeneration
  • Stem cells
  • Tissue engineering

ASJC Scopus subject areas

  • Medicine(all)

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