TY - JOUR
T1 - Use of the Esophageal Sponge in Directing Food Reintroduction in Eosinophilic Esophagitis
AU - Alexander, Jeffrey A.
AU - Ravi, Karthik
AU - Symrk, Thomas C.
AU - Wu, Tsung The
AU - Lavey, Crystal J.
AU - Geno, Debra
AU - Johnson, Alyssa J.
AU - Lennon, Ryan J.
AU - Collins, Margaret H.
AU - Dellon, Evan S.
AU - Katzka, David A.
N1 - Publisher Copyright:
© 2023 AGA Institute
PY - 2023/2
Y1 - 2023/2
N2 - Background & Aims: Dietary therapy is successful in eosinophilic esophagitis (EoE) but requires multiple upper endoscopies. The aim of this study was to determine if food reintroduction in EoE can be directed by minimally-invasive esophageal sponge cytology. Methods: In this prospective non-blinded trial, 22 responders to 6-food elimination diets underwent sequential food reintroduction guided by esophageal sponge cytology. Foods were reintroduced followed by unsedated esophageal sponge cytology assessment. A food trigger was defined by sponge cytology peak eosinophil count of ≥15 eos/high-powered field (hpf). Symptoms (EoE symptom activity index [EEsAI]), endoscopic score (EoE endoscopic reference score [EREFS]), and biopsy histology (peak eosinophil count) were collected pre-dietary therapy and post-dietary therapy, and then 4 weeks post food reintroduction. Results: The EEsAI and EREFS were similar post-dietary therapy to post-food reintroduction: 12.0 (interquartile range [IQR], 0.0–27.0) vs 16.5 (IQR, 9.0–28.8) (P = .265) and 1.5 (IQR, 0.2–3.0) vs 1.0 (IQR, 0.0–2.0) (P = .185). However, the peak eosinophil count was increased post-food reintroduction compared with post-dietary therapy: 20.0 (IQR, 5.0–51.5) vs 2.0 (IQR, 1.0–4.0) (P < .001), suggesting a failure of identification of all food triggers. The peak eosinophil count was lower post-food reintroduction compared with pre-dietary therapy: 20.0 (IQR, 5.0–51.5) vs 52.0 (IQR, 30.8–76.2) (P = .008). At the post food reintroduction evaluation, sponge cytology and biopsy histology were in agreement in 59% (13/22) of cases using a cutoff of <15 eos/hpf and 68% (15/22) of cases using a cutoff of <6 eos/hpf. Conclusions: In the first study to evaluate a non-endoscopic technique in the clinical management of EoE, the esophageal sponge was moderately successful at guiding food reintroduction in EoE dietary responders in the outpatient setting. Clinicaltrials.gov, Number NCT02599558.
AB - Background & Aims: Dietary therapy is successful in eosinophilic esophagitis (EoE) but requires multiple upper endoscopies. The aim of this study was to determine if food reintroduction in EoE can be directed by minimally-invasive esophageal sponge cytology. Methods: In this prospective non-blinded trial, 22 responders to 6-food elimination diets underwent sequential food reintroduction guided by esophageal sponge cytology. Foods were reintroduced followed by unsedated esophageal sponge cytology assessment. A food trigger was defined by sponge cytology peak eosinophil count of ≥15 eos/high-powered field (hpf). Symptoms (EoE symptom activity index [EEsAI]), endoscopic score (EoE endoscopic reference score [EREFS]), and biopsy histology (peak eosinophil count) were collected pre-dietary therapy and post-dietary therapy, and then 4 weeks post food reintroduction. Results: The EEsAI and EREFS were similar post-dietary therapy to post-food reintroduction: 12.0 (interquartile range [IQR], 0.0–27.0) vs 16.5 (IQR, 9.0–28.8) (P = .265) and 1.5 (IQR, 0.2–3.0) vs 1.0 (IQR, 0.0–2.0) (P = .185). However, the peak eosinophil count was increased post-food reintroduction compared with post-dietary therapy: 20.0 (IQR, 5.0–51.5) vs 2.0 (IQR, 1.0–4.0) (P < .001), suggesting a failure of identification of all food triggers. The peak eosinophil count was lower post-food reintroduction compared with pre-dietary therapy: 20.0 (IQR, 5.0–51.5) vs 52.0 (IQR, 30.8–76.2) (P = .008). At the post food reintroduction evaluation, sponge cytology and biopsy histology were in agreement in 59% (13/22) of cases using a cutoff of <15 eos/hpf and 68% (15/22) of cases using a cutoff of <6 eos/hpf. Conclusions: In the first study to evaluate a non-endoscopic technique in the clinical management of EoE, the esophageal sponge was moderately successful at guiding food reintroduction in EoE dietary responders in the outpatient setting. Clinicaltrials.gov, Number NCT02599558.
KW - Eosinophilic Esophagitis
KW - Esophageal Sponge Cytology
KW - Food Reintroduction
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U2 - 10.1016/j.cgh.2022.05.029
DO - 10.1016/j.cgh.2022.05.029
M3 - Article
C2 - 35697266
AN - SCOPUS:85136305260
SN - 1542-3565
VL - 21
SP - 299-306.e3
JO - Clinical Gastroenterology and Hepatology
JF - Clinical Gastroenterology and Hepatology
IS - 2
ER -