Use of Statins in Patients with Chronic Liver Disease and Cirrhosis: Current Views and Prospects

Jose Ignacio Vargas, Marco Arrese, Vijay Shah, Juan Pablo Arab

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Purpose of review: The purpose of this study is to analyze the current evidence regarding the use of statins in patients with chronic liver disease and cirrhosis. Recent findings: Chronic liver disease (CLD), cirrhosis, and its complications, including hepatocellular carcinoma (HCC), are significant public health problems. The use of statins in patients with CLD has been a matter of concern, and physicians are often reluctant to its prescription in these patients. This mainly relates to the potential occurrence of drug-induced liver injury. However, newer evidence from pre-clinical and clinical research has shown that statins are drugs with a potentially beneficial impact on the natural history of cirrhosis, on portal hypertension, and in HCC prevention. Summary: In this review, we summarize current evidence regarding the influence of statins in endothelial dysfunction in CLD, their ability to modulate hepatic fibrogenesis, and their vasoprotective effects in portal hypertension; we also focus on existing data about the impact of statins in cirrhosis development, progression, and complications and critically assess the current concerns about its use in patients with CLD.

Original languageEnglish (US)
Article number43
JournalCurrent Gastroenterology Reports
Volume19
Issue number9
DOIs
StatePublished - Sep 1 2017

Keywords

  • Chronic liver diseases
  • Cirrhosis
  • Drug-induced liver injury
  • Hepatocellular carcinoma
  • HMG-CoA reductase inhibitors
  • Portal hypertension
  • Statins
  • Variceal bleeding

ASJC Scopus subject areas

  • Gastroenterology

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