Use of sildenafil (Viagra) in patients with cardiovascular disease

Melvin D. Cheitlin, Adolph M. Hutter, Ralph G. Brindis, Peter Ganz, Sanjay Kaul, Richard O. Russell, Randall M. Zusman, James S. Forrester, Pamela S. Douglas, David P. Faxon, John D. Fisher, Raymond J Gibbons, Jonathan L. Halperin, Judith S. Hochman, Sanjiv Kaul, William S. Weintraub, William L. Winters, Michael J. Wolk

Research output: Contribution to journalArticle

258 Citations (Scopus)

Abstract

The pharmaceutical preparation sildenafil citrate (Viagra) is being widely prescribed as a treatment for male erectile dysfunction, a common problem that in the United States affects between 10 and 30 million men. The introduction of sildenafil has been a valuable contribution to the treatment of erectile dysfunction, which is a relatively common occurrence in patients with cardiovascular disease. This article is written to appropriately caution and not to unduly alarm physicians in their use of sildenafil in patients with heart disease. Reported cardiovascular side effects in the normal healthy population are typically minor and associated with vasodilatation (ie, headache, flushing, and small decreases in systolic and diastolic blood pressures). However, although their incidence is small, serious cardiovascular events, including significant hypotension, can occur in certain populations at risk. Most at risk are individuals who are concurrently taking organic nitrates. Organic nitrate preparations are commonly prescribed to manage the symptoms of angina pectoris. The coadministration of nitrates and Viagra significantly increases the risk of potentially life-threatening hypotension. Therefore, Viagra should not be prescribed to patients receiving any form of nitrate therapy. Although definitive evidence is currently lacking, it is possible that a precipitous reduction in blood pressure with nitrate use may occur over the initial 24 hours after a dose of Viagra. Thus, for patients who experience an acute cardiac ischemic event and who have taken Viagra within the past 24 hours, administration of nitrates should be avoided. In the event that nitrates are given, especially within this critical time interval, it is essential to have the capability to support the patient with fluid resuscitation and α- adrenergic agonists if needed. In patients with recurring angina after Viagra use, other nonnitrate antianginal agents, such as β-blockers, should be considered. Other patients in whom the use of Viagra is potentially hazardous include those with active coronary ischemia; those with congestive heart failure and borderline low blood volume and low blood pressure status; those with complicated, multidrug, antihypertensive therapy regimens; and those taking medications that may affect the metabolic clearance of Viagra. With respect to patients following complicated multidrug, antihypertensive programs, the randomized studies included a large number of hypertensive patients. However, most patients were controlled with 1 antihypertensive agent, and only a small number were controlled with 3 antihypertensive agents. Until adequate studies are done in these subgroups of patients, sildenafil should be prescribed with caution. Viagra acts as a selective inhibitor of cyclic GMP (cGMP)-specific phosphodiesterase type 5, resulting in smooth muscle relaxation, vasodilatation, and enhanced penile erection. Although the cardiovascular effects of sildenafil reported in available randomized, controlled clinical trials were relatively minor, heart disease patients represented only a small fraction of studied patients, and patients with heart failure, patients with myocardial infarction or stroke within 6 months, or patients with uncontrolled hypertension were not included in these studies. Thus, there are possible problems in the use of Viagra in these patients that have not been adequately studied. Given the increasing reports of deaths in which the use of Viagra may be implicated, clinicians need to exercise caution when advising their patients with heart disease about taking this medication. Specific recommendations regarding sildenafil (Viagra) and the cardiac patient are summarized in the following Table.

Original languageEnglish (US)
Pages (from-to)168-177
Number of pages10
JournalCirculation
Volume99
Issue number1
StatePublished - Jan 5 1999

Fingerprint

Cardiovascular Diseases
Nitrates
Antihypertensive Agents
Hypotension
Sildenafil Citrate
Heart Diseases
Erectile Dysfunction
Blood Pressure
Vasodilation
Heart Failure
Type 5 Cyclic Nucleotide Phosphodiesterases
Penile Erection
Adrenergic Agonists
Muscle Relaxation
Cyclic GMP
Angina Pectoris
Therapeutics
Blood Volume
Resuscitation
Smooth Muscle

Keywords

  • ACC/AHA Expert Consensus Documents
  • Angina
  • Nitric oxide
  • Sildenafil
  • Viagra

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Cheitlin, M. D., Hutter, A. M., Brindis, R. G., Ganz, P., Kaul, S., Russell, R. O., ... Wolk, M. J. (1999). Use of sildenafil (Viagra) in patients with cardiovascular disease. Circulation, 99(1), 168-177.

Use of sildenafil (Viagra) in patients with cardiovascular disease. / Cheitlin, Melvin D.; Hutter, Adolph M.; Brindis, Ralph G.; Ganz, Peter; Kaul, Sanjay; Russell, Richard O.; Zusman, Randall M.; Forrester, James S.; Douglas, Pamela S.; Faxon, David P.; Fisher, John D.; Gibbons, Raymond J; Halperin, Jonathan L.; Hochman, Judith S.; Kaul, Sanjiv; Weintraub, William S.; Winters, William L.; Wolk, Michael J.

In: Circulation, Vol. 99, No. 1, 05.01.1999, p. 168-177.

Research output: Contribution to journalArticle

Cheitlin, MD, Hutter, AM, Brindis, RG, Ganz, P, Kaul, S, Russell, RO, Zusman, RM, Forrester, JS, Douglas, PS, Faxon, DP, Fisher, JD, Gibbons, RJ, Halperin, JL, Hochman, JS, Kaul, S, Weintraub, WS, Winters, WL & Wolk, MJ 1999, 'Use of sildenafil (Viagra) in patients with cardiovascular disease', Circulation, vol. 99, no. 1, pp. 168-177.
Cheitlin MD, Hutter AM, Brindis RG, Ganz P, Kaul S, Russell RO et al. Use of sildenafil (Viagra) in patients with cardiovascular disease. Circulation. 1999 Jan 5;99(1):168-177.
Cheitlin, Melvin D. ; Hutter, Adolph M. ; Brindis, Ralph G. ; Ganz, Peter ; Kaul, Sanjay ; Russell, Richard O. ; Zusman, Randall M. ; Forrester, James S. ; Douglas, Pamela S. ; Faxon, David P. ; Fisher, John D. ; Gibbons, Raymond J ; Halperin, Jonathan L. ; Hochman, Judith S. ; Kaul, Sanjiv ; Weintraub, William S. ; Winters, William L. ; Wolk, Michael J. / Use of sildenafil (Viagra) in patients with cardiovascular disease. In: Circulation. 1999 ; Vol. 99, No. 1. pp. 168-177.
@article{d3f44e6e6b304807a010223f5f877dec,
title = "Use of sildenafil (Viagra) in patients with cardiovascular disease",
abstract = "The pharmaceutical preparation sildenafil citrate (Viagra) is being widely prescribed as a treatment for male erectile dysfunction, a common problem that in the United States affects between 10 and 30 million men. The introduction of sildenafil has been a valuable contribution to the treatment of erectile dysfunction, which is a relatively common occurrence in patients with cardiovascular disease. This article is written to appropriately caution and not to unduly alarm physicians in their use of sildenafil in patients with heart disease. Reported cardiovascular side effects in the normal healthy population are typically minor and associated with vasodilatation (ie, headache, flushing, and small decreases in systolic and diastolic blood pressures). However, although their incidence is small, serious cardiovascular events, including significant hypotension, can occur in certain populations at risk. Most at risk are individuals who are concurrently taking organic nitrates. Organic nitrate preparations are commonly prescribed to manage the symptoms of angina pectoris. The coadministration of nitrates and Viagra significantly increases the risk of potentially life-threatening hypotension. Therefore, Viagra should not be prescribed to patients receiving any form of nitrate therapy. Although definitive evidence is currently lacking, it is possible that a precipitous reduction in blood pressure with nitrate use may occur over the initial 24 hours after a dose of Viagra. Thus, for patients who experience an acute cardiac ischemic event and who have taken Viagra within the past 24 hours, administration of nitrates should be avoided. In the event that nitrates are given, especially within this critical time interval, it is essential to have the capability to support the patient with fluid resuscitation and α- adrenergic agonists if needed. In patients with recurring angina after Viagra use, other nonnitrate antianginal agents, such as β-blockers, should be considered. Other patients in whom the use of Viagra is potentially hazardous include those with active coronary ischemia; those with congestive heart failure and borderline low blood volume and low blood pressure status; those with complicated, multidrug, antihypertensive therapy regimens; and those taking medications that may affect the metabolic clearance of Viagra. With respect to patients following complicated multidrug, antihypertensive programs, the randomized studies included a large number of hypertensive patients. However, most patients were controlled with 1 antihypertensive agent, and only a small number were controlled with 3 antihypertensive agents. Until adequate studies are done in these subgroups of patients, sildenafil should be prescribed with caution. Viagra acts as a selective inhibitor of cyclic GMP (cGMP)-specific phosphodiesterase type 5, resulting in smooth muscle relaxation, vasodilatation, and enhanced penile erection. Although the cardiovascular effects of sildenafil reported in available randomized, controlled clinical trials were relatively minor, heart disease patients represented only a small fraction of studied patients, and patients with heart failure, patients with myocardial infarction or stroke within 6 months, or patients with uncontrolled hypertension were not included in these studies. Thus, there are possible problems in the use of Viagra in these patients that have not been adequately studied. Given the increasing reports of deaths in which the use of Viagra may be implicated, clinicians need to exercise caution when advising their patients with heart disease about taking this medication. Specific recommendations regarding sildenafil (Viagra) and the cardiac patient are summarized in the following Table.",
keywords = "ACC/AHA Expert Consensus Documents, Angina, Nitric oxide, Sildenafil, Viagra",
author = "Cheitlin, {Melvin D.} and Hutter, {Adolph M.} and Brindis, {Ralph G.} and Peter Ganz and Sanjay Kaul and Russell, {Richard O.} and Zusman, {Randall M.} and Forrester, {James S.} and Douglas, {Pamela S.} and Faxon, {David P.} and Fisher, {John D.} and Gibbons, {Raymond J} and Halperin, {Jonathan L.} and Hochman, {Judith S.} and Sanjiv Kaul and Weintraub, {William S.} and Winters, {William L.} and Wolk, {Michael J.}",
year = "1999",
month = "1",
day = "5",
language = "English (US)",
volume = "99",
pages = "168--177",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Use of sildenafil (Viagra) in patients with cardiovascular disease

AU - Cheitlin, Melvin D.

AU - Hutter, Adolph M.

AU - Brindis, Ralph G.

AU - Ganz, Peter

AU - Kaul, Sanjay

AU - Russell, Richard O.

AU - Zusman, Randall M.

AU - Forrester, James S.

AU - Douglas, Pamela S.

AU - Faxon, David P.

AU - Fisher, John D.

AU - Gibbons, Raymond J

AU - Halperin, Jonathan L.

AU - Hochman, Judith S.

AU - Kaul, Sanjiv

AU - Weintraub, William S.

AU - Winters, William L.

AU - Wolk, Michael J.

PY - 1999/1/5

Y1 - 1999/1/5

N2 - The pharmaceutical preparation sildenafil citrate (Viagra) is being widely prescribed as a treatment for male erectile dysfunction, a common problem that in the United States affects between 10 and 30 million men. The introduction of sildenafil has been a valuable contribution to the treatment of erectile dysfunction, which is a relatively common occurrence in patients with cardiovascular disease. This article is written to appropriately caution and not to unduly alarm physicians in their use of sildenafil in patients with heart disease. Reported cardiovascular side effects in the normal healthy population are typically minor and associated with vasodilatation (ie, headache, flushing, and small decreases in systolic and diastolic blood pressures). However, although their incidence is small, serious cardiovascular events, including significant hypotension, can occur in certain populations at risk. Most at risk are individuals who are concurrently taking organic nitrates. Organic nitrate preparations are commonly prescribed to manage the symptoms of angina pectoris. The coadministration of nitrates and Viagra significantly increases the risk of potentially life-threatening hypotension. Therefore, Viagra should not be prescribed to patients receiving any form of nitrate therapy. Although definitive evidence is currently lacking, it is possible that a precipitous reduction in blood pressure with nitrate use may occur over the initial 24 hours after a dose of Viagra. Thus, for patients who experience an acute cardiac ischemic event and who have taken Viagra within the past 24 hours, administration of nitrates should be avoided. In the event that nitrates are given, especially within this critical time interval, it is essential to have the capability to support the patient with fluid resuscitation and α- adrenergic agonists if needed. In patients with recurring angina after Viagra use, other nonnitrate antianginal agents, such as β-blockers, should be considered. Other patients in whom the use of Viagra is potentially hazardous include those with active coronary ischemia; those with congestive heart failure and borderline low blood volume and low blood pressure status; those with complicated, multidrug, antihypertensive therapy regimens; and those taking medications that may affect the metabolic clearance of Viagra. With respect to patients following complicated multidrug, antihypertensive programs, the randomized studies included a large number of hypertensive patients. However, most patients were controlled with 1 antihypertensive agent, and only a small number were controlled with 3 antihypertensive agents. Until adequate studies are done in these subgroups of patients, sildenafil should be prescribed with caution. Viagra acts as a selective inhibitor of cyclic GMP (cGMP)-specific phosphodiesterase type 5, resulting in smooth muscle relaxation, vasodilatation, and enhanced penile erection. Although the cardiovascular effects of sildenafil reported in available randomized, controlled clinical trials were relatively minor, heart disease patients represented only a small fraction of studied patients, and patients with heart failure, patients with myocardial infarction or stroke within 6 months, or patients with uncontrolled hypertension were not included in these studies. Thus, there are possible problems in the use of Viagra in these patients that have not been adequately studied. Given the increasing reports of deaths in which the use of Viagra may be implicated, clinicians need to exercise caution when advising their patients with heart disease about taking this medication. Specific recommendations regarding sildenafil (Viagra) and the cardiac patient are summarized in the following Table.

AB - The pharmaceutical preparation sildenafil citrate (Viagra) is being widely prescribed as a treatment for male erectile dysfunction, a common problem that in the United States affects between 10 and 30 million men. The introduction of sildenafil has been a valuable contribution to the treatment of erectile dysfunction, which is a relatively common occurrence in patients with cardiovascular disease. This article is written to appropriately caution and not to unduly alarm physicians in their use of sildenafil in patients with heart disease. Reported cardiovascular side effects in the normal healthy population are typically minor and associated with vasodilatation (ie, headache, flushing, and small decreases in systolic and diastolic blood pressures). However, although their incidence is small, serious cardiovascular events, including significant hypotension, can occur in certain populations at risk. Most at risk are individuals who are concurrently taking organic nitrates. Organic nitrate preparations are commonly prescribed to manage the symptoms of angina pectoris. The coadministration of nitrates and Viagra significantly increases the risk of potentially life-threatening hypotension. Therefore, Viagra should not be prescribed to patients receiving any form of nitrate therapy. Although definitive evidence is currently lacking, it is possible that a precipitous reduction in blood pressure with nitrate use may occur over the initial 24 hours after a dose of Viagra. Thus, for patients who experience an acute cardiac ischemic event and who have taken Viagra within the past 24 hours, administration of nitrates should be avoided. In the event that nitrates are given, especially within this critical time interval, it is essential to have the capability to support the patient with fluid resuscitation and α- adrenergic agonists if needed. In patients with recurring angina after Viagra use, other nonnitrate antianginal agents, such as β-blockers, should be considered. Other patients in whom the use of Viagra is potentially hazardous include those with active coronary ischemia; those with congestive heart failure and borderline low blood volume and low blood pressure status; those with complicated, multidrug, antihypertensive therapy regimens; and those taking medications that may affect the metabolic clearance of Viagra. With respect to patients following complicated multidrug, antihypertensive programs, the randomized studies included a large number of hypertensive patients. However, most patients were controlled with 1 antihypertensive agent, and only a small number were controlled with 3 antihypertensive agents. Until adequate studies are done in these subgroups of patients, sildenafil should be prescribed with caution. Viagra acts as a selective inhibitor of cyclic GMP (cGMP)-specific phosphodiesterase type 5, resulting in smooth muscle relaxation, vasodilatation, and enhanced penile erection. Although the cardiovascular effects of sildenafil reported in available randomized, controlled clinical trials were relatively minor, heart disease patients represented only a small fraction of studied patients, and patients with heart failure, patients with myocardial infarction or stroke within 6 months, or patients with uncontrolled hypertension were not included in these studies. Thus, there are possible problems in the use of Viagra in these patients that have not been adequately studied. Given the increasing reports of deaths in which the use of Viagra may be implicated, clinicians need to exercise caution when advising their patients with heart disease about taking this medication. Specific recommendations regarding sildenafil (Viagra) and the cardiac patient are summarized in the following Table.

KW - ACC/AHA Expert Consensus Documents

KW - Angina

KW - Nitric oxide

KW - Sildenafil

KW - Viagra

UR - http://www.scopus.com/inward/record.url?scp=0033547738&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033547738&partnerID=8YFLogxK

M3 - Article

C2 - 9884398

AN - SCOPUS:0033547738

VL - 99

SP - 168

EP - 177

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 1

ER -