@inbook{ed6f478dfe60484ebab168feb6de49b1,
title = "Use of rapamycin in the induction of tolerogenic dendritic cells",
abstract = "Rapamycin (RAPA), a macrocyclic triene antibiotic pro-drug, is a clinically-utilized 'tolerance-sparing' immunosuppressant that inhibits the activity of T, B, and NK cells. Furthermore, maturation-resistance and tolerogenic properties of dendritic cells (DC) can be supported and preserved by conditioning with RAPA. Propagation of murine bone marrow (BM)-derived myeloid DC (mDC) in clinically relevant concentrations of RAPA (RAPA-DC) generates phenotypically immature DC with low levels of MHC and significantly reduced co-stimulatory molecules (especially CD86), even when exposed to inflammatory stimuli. RAPA-DC are weak stimulators of T cells and induce hyporesponsiveness and apoptosis in allo-reactive T cells. An interesting observation has been that RAPA-DC retain the ability to stimulate and enrich the regulatory T cells (Treg). Presumably as a result of these properties, alloantigen (alloAg)-pulsed recipient-derived DC are effective in subverting anti-allograft immune responses in rodent transplant models, making them an attractive subject for further investigation of their tolerance-promoting potential.",
author = "Thomson, {Angus W.} and Ryan Fischer and Turnquist, {Heth R.} and Timu{\c c}in Taner",
note = "Copyright: Copyright 2010 Elsevier B.V., All rights reserved.",
year = "2009",
doi = "10.1007/978-3-540-71029-5-10",
language = "English (US)",
isbn = "9783540710288",
series = "Handbook of Experimental Pharmacology",
pages = "215--232",
booktitle = "Dendritic Cells",
}