Use of nonvolume-reduced (unmanipulated after thawing) umbilical cord blood stem cells for allogeneic transplantation results in safe engraftment

T. Hahn, U. Bunworasate, M. C. George, A. S. Bir, W. Chinratanalab, A. R. Alam, B. Bambach, M. R. Baer, James L Slack, M. Wetzler, J. L. Becker, P. L. McCarthy

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Volume reduction of umbilical cord blood (UCB) units before infusion is standard in most transplant centers. We examined 26 patients who underwent transplantation from May 1997 to December 2001 with unmanipulated (n = 18) or volume-reduced (n = 8) UCB units for engraftment. Of 18 unmanipulated UCBT patients, 16 achieved ANC>500/mm3, a median of 26 days (range, 16-104) post-UCBT; two died before engraftment on days + 2 and + 14. Of 18 unmanipulated UCBT patients, 10 achieved platelet recovery, a median of 60.5 days (range, 41-144) post-UCBT; eight patients died before platelet recovery + 2 to + 255 days post-UCBT. These results are similar to several reported studies and our series utilizing volume-reduced UCB units for UCBT. At a median follow-up of 29.5 months, the 100-day and 3-year overall survivals of unmanipulated UCBT were 61.1% (95% CI, 38.6-83.6) and 48.6% (95% CI, 24.8-72.4) and of volume-reduced UCBT were 60% (95% CI, 24.4-95.6) and 22.5% (95% CI, 0-58.7). There was no serious toxicity from UCB infusion using unmanipulated UCB units. We conclude that unmanipulated UCB units may be infused safely into UCBT patients with adequate engraftment and survival.

Original languageEnglish (US)
Pages (from-to)145-150
Number of pages6
JournalBone Marrow Transplantation
Volume32
Issue number2
DOIs
StatePublished - Jul 2003
Externally publishedYes

Fingerprint

Cord Blood Stem Cell Transplantation
Homologous Transplantation
Fetal Blood
Blood Platelets
Survival
Transplantation
Transplants

Keywords

  • Cord blood transplantation
  • Leukemia
  • Therapy
  • Volume reduction

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Use of nonvolume-reduced (unmanipulated after thawing) umbilical cord blood stem cells for allogeneic transplantation results in safe engraftment. / Hahn, T.; Bunworasate, U.; George, M. C.; Bir, A. S.; Chinratanalab, W.; Alam, A. R.; Bambach, B.; Baer, M. R.; Slack, James L; Wetzler, M.; Becker, J. L.; McCarthy, P. L.

In: Bone Marrow Transplantation, Vol. 32, No. 2, 07.2003, p. 145-150.

Research output: Contribution to journalArticle

Hahn, T, Bunworasate, U, George, MC, Bir, AS, Chinratanalab, W, Alam, AR, Bambach, B, Baer, MR, Slack, JL, Wetzler, M, Becker, JL & McCarthy, PL 2003, 'Use of nonvolume-reduced (unmanipulated after thawing) umbilical cord blood stem cells for allogeneic transplantation results in safe engraftment', Bone Marrow Transplantation, vol. 32, no. 2, pp. 145-150. https://doi.org/10.1038/sj.bmt.1704091
Hahn, T. ; Bunworasate, U. ; George, M. C. ; Bir, A. S. ; Chinratanalab, W. ; Alam, A. R. ; Bambach, B. ; Baer, M. R. ; Slack, James L ; Wetzler, M. ; Becker, J. L. ; McCarthy, P. L. / Use of nonvolume-reduced (unmanipulated after thawing) umbilical cord blood stem cells for allogeneic transplantation results in safe engraftment. In: Bone Marrow Transplantation. 2003 ; Vol. 32, No. 2. pp. 145-150.
@article{fce1232172e546419cabbb024c15c10e,
title = "Use of nonvolume-reduced (unmanipulated after thawing) umbilical cord blood stem cells for allogeneic transplantation results in safe engraftment",
abstract = "Volume reduction of umbilical cord blood (UCB) units before infusion is standard in most transplant centers. We examined 26 patients who underwent transplantation from May 1997 to December 2001 with unmanipulated (n = 18) or volume-reduced (n = 8) UCB units for engraftment. Of 18 unmanipulated UCBT patients, 16 achieved ANC>500/mm3, a median of 26 days (range, 16-104) post-UCBT; two died before engraftment on days + 2 and + 14. Of 18 unmanipulated UCBT patients, 10 achieved platelet recovery, a median of 60.5 days (range, 41-144) post-UCBT; eight patients died before platelet recovery + 2 to + 255 days post-UCBT. These results are similar to several reported studies and our series utilizing volume-reduced UCB units for UCBT. At a median follow-up of 29.5 months, the 100-day and 3-year overall survivals of unmanipulated UCBT were 61.1{\%} (95{\%} CI, 38.6-83.6) and 48.6{\%} (95{\%} CI, 24.8-72.4) and of volume-reduced UCBT were 60{\%} (95{\%} CI, 24.4-95.6) and 22.5{\%} (95{\%} CI, 0-58.7). There was no serious toxicity from UCB infusion using unmanipulated UCB units. We conclude that unmanipulated UCB units may be infused safely into UCBT patients with adequate engraftment and survival.",
keywords = "Cord blood transplantation, Leukemia, Therapy, Volume reduction",
author = "T. Hahn and U. Bunworasate and George, {M. C.} and Bir, {A. S.} and W. Chinratanalab and Alam, {A. R.} and B. Bambach and Baer, {M. R.} and Slack, {James L} and M. Wetzler and Becker, {J. L.} and McCarthy, {P. L.}",
year = "2003",
month = "7",
doi = "10.1038/sj.bmt.1704091",
language = "English (US)",
volume = "32",
pages = "145--150",
journal = "Bone Marrow Transplantation",
issn = "0268-3369",
publisher = "Nature Publishing Group",
number = "2",

}

TY - JOUR

T1 - Use of nonvolume-reduced (unmanipulated after thawing) umbilical cord blood stem cells for allogeneic transplantation results in safe engraftment

AU - Hahn, T.

AU - Bunworasate, U.

AU - George, M. C.

AU - Bir, A. S.

AU - Chinratanalab, W.

AU - Alam, A. R.

AU - Bambach, B.

AU - Baer, M. R.

AU - Slack, James L

AU - Wetzler, M.

AU - Becker, J. L.

AU - McCarthy, P. L.

PY - 2003/7

Y1 - 2003/7

N2 - Volume reduction of umbilical cord blood (UCB) units before infusion is standard in most transplant centers. We examined 26 patients who underwent transplantation from May 1997 to December 2001 with unmanipulated (n = 18) or volume-reduced (n = 8) UCB units for engraftment. Of 18 unmanipulated UCBT patients, 16 achieved ANC>500/mm3, a median of 26 days (range, 16-104) post-UCBT; two died before engraftment on days + 2 and + 14. Of 18 unmanipulated UCBT patients, 10 achieved platelet recovery, a median of 60.5 days (range, 41-144) post-UCBT; eight patients died before platelet recovery + 2 to + 255 days post-UCBT. These results are similar to several reported studies and our series utilizing volume-reduced UCB units for UCBT. At a median follow-up of 29.5 months, the 100-day and 3-year overall survivals of unmanipulated UCBT were 61.1% (95% CI, 38.6-83.6) and 48.6% (95% CI, 24.8-72.4) and of volume-reduced UCBT were 60% (95% CI, 24.4-95.6) and 22.5% (95% CI, 0-58.7). There was no serious toxicity from UCB infusion using unmanipulated UCB units. We conclude that unmanipulated UCB units may be infused safely into UCBT patients with adequate engraftment and survival.

AB - Volume reduction of umbilical cord blood (UCB) units before infusion is standard in most transplant centers. We examined 26 patients who underwent transplantation from May 1997 to December 2001 with unmanipulated (n = 18) or volume-reduced (n = 8) UCB units for engraftment. Of 18 unmanipulated UCBT patients, 16 achieved ANC>500/mm3, a median of 26 days (range, 16-104) post-UCBT; two died before engraftment on days + 2 and + 14. Of 18 unmanipulated UCBT patients, 10 achieved platelet recovery, a median of 60.5 days (range, 41-144) post-UCBT; eight patients died before platelet recovery + 2 to + 255 days post-UCBT. These results are similar to several reported studies and our series utilizing volume-reduced UCB units for UCBT. At a median follow-up of 29.5 months, the 100-day and 3-year overall survivals of unmanipulated UCBT were 61.1% (95% CI, 38.6-83.6) and 48.6% (95% CI, 24.8-72.4) and of volume-reduced UCBT were 60% (95% CI, 24.4-95.6) and 22.5% (95% CI, 0-58.7). There was no serious toxicity from UCB infusion using unmanipulated UCB units. We conclude that unmanipulated UCB units may be infused safely into UCBT patients with adequate engraftment and survival.

KW - Cord blood transplantation

KW - Leukemia

KW - Therapy

KW - Volume reduction

UR - http://www.scopus.com/inward/record.url?scp=10744222676&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10744222676&partnerID=8YFLogxK

U2 - 10.1038/sj.bmt.1704091

DO - 10.1038/sj.bmt.1704091

M3 - Article

C2 - 12838278

AN - SCOPUS:10744222676

VL - 32

SP - 145

EP - 150

JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

SN - 0268-3369

IS - 2

ER -