Use of heparin-coated stents in neurovascular interventional procedures: Preliminary experience with 10 patients

Richard J. Parkinson, Christopher P. Demers, Joseph G. Adel, Elad I. Levy, Eric Sauvageau, Ricardo A. Hanel, Ali Shaibani, Lee R. Guterman, L. Nelson Hopkins, H. Hunt Batjer, Bernard Bendok

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

OBJECTIVE: Currently, there is minimal published data on the use of heparin-coated stents in the neurovasculature; however, these stents have a proven clinical record in the treatment of coronary disease. This article details our experience with the safety and technical aspects of stent deployment in the first 10 patients who had heparin-coated stents placed in the intracranial and cervical vasculature and the preliminary follow-up in most cases. METHODS: We retrospectively reviewed the clinical history, intra- and periprocedural data, and imaging for the patients who received heparin-coated stents in the cervical and intracranial vasculature for cerebrovascular disease between October 2002 and October 2003. RESULTS: Thirteen heparin-coated stents were placed in 10 patients. Seven out of the 10 patients had heparin-coated stents placed in the posterior circulation; the remaining three patients had stents placed in the anterior circulation. Four patients had stents placed intracranially. There was no acute or subacute in-stent thrombosis and no procedure-related complications. Follow-up was performed on most patients, with no clinical symptoms attributable to restenosis in any patient. CONCLUSION: This small series suggests that heparin-coated stents are safe for use in the treatment of cervical and intracranial atherosclerotic disease. Longer-term follow-up is needed to study the heparin coating effect on in-stent restenosis rates and to assess the long-term durability and clinical efficacy of this stent. The use of drug-coated stents in the cerebrovascular circulation is an area that warrants further investigation.

Original languageEnglish (US)
Pages (from-to)812-821
Number of pages10
JournalNeurosurgery
Volume59
Issue number4
DOIs
StatePublished - Oct 2006
Externally publishedYes

Fingerprint

Stents
Heparin
Cerebrovascular Circulation
Cerebrovascular Disorders
Drug-Eluting Stents
Coronary Disease
Thrombosis
Safety

Keywords

  • Heparin-coated stents
  • Intracranial atherosclerosis
  • Percutaneous transluminal angioplasty and stenting

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Use of heparin-coated stents in neurovascular interventional procedures : Preliminary experience with 10 patients. / Parkinson, Richard J.; Demers, Christopher P.; Adel, Joseph G.; Levy, Elad I.; Sauvageau, Eric; Hanel, Ricardo A.; Shaibani, Ali; Guterman, Lee R.; Hopkins, L. Nelson; Batjer, H. Hunt; Bendok, Bernard.

In: Neurosurgery, Vol. 59, No. 4, 10.2006, p. 812-821.

Research output: Contribution to journalArticle

Parkinson, RJ, Demers, CP, Adel, JG, Levy, EI, Sauvageau, E, Hanel, RA, Shaibani, A, Guterman, LR, Hopkins, LN, Batjer, HH & Bendok, B 2006, 'Use of heparin-coated stents in neurovascular interventional procedures: Preliminary experience with 10 patients', Neurosurgery, vol. 59, no. 4, pp. 812-821. https://doi.org/10.1227/01.NEU.0000232836.66310.46
Parkinson, Richard J. ; Demers, Christopher P. ; Adel, Joseph G. ; Levy, Elad I. ; Sauvageau, Eric ; Hanel, Ricardo A. ; Shaibani, Ali ; Guterman, Lee R. ; Hopkins, L. Nelson ; Batjer, H. Hunt ; Bendok, Bernard. / Use of heparin-coated stents in neurovascular interventional procedures : Preliminary experience with 10 patients. In: Neurosurgery. 2006 ; Vol. 59, No. 4. pp. 812-821.
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AU - Parkinson, Richard J.

AU - Demers, Christopher P.

AU - Adel, Joseph G.

AU - Levy, Elad I.

AU - Sauvageau, Eric

AU - Hanel, Ricardo A.

AU - Shaibani, Ali

AU - Guterman, Lee R.

AU - Hopkins, L. Nelson

AU - Batjer, H. Hunt

AU - Bendok, Bernard

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N2 - OBJECTIVE: Currently, there is minimal published data on the use of heparin-coated stents in the neurovasculature; however, these stents have a proven clinical record in the treatment of coronary disease. This article details our experience with the safety and technical aspects of stent deployment in the first 10 patients who had heparin-coated stents placed in the intracranial and cervical vasculature and the preliminary follow-up in most cases. METHODS: We retrospectively reviewed the clinical history, intra- and periprocedural data, and imaging for the patients who received heparin-coated stents in the cervical and intracranial vasculature for cerebrovascular disease between October 2002 and October 2003. RESULTS: Thirteen heparin-coated stents were placed in 10 patients. Seven out of the 10 patients had heparin-coated stents placed in the posterior circulation; the remaining three patients had stents placed in the anterior circulation. Four patients had stents placed intracranially. There was no acute or subacute in-stent thrombosis and no procedure-related complications. Follow-up was performed on most patients, with no clinical symptoms attributable to restenosis in any patient. CONCLUSION: This small series suggests that heparin-coated stents are safe for use in the treatment of cervical and intracranial atherosclerotic disease. Longer-term follow-up is needed to study the heparin coating effect on in-stent restenosis rates and to assess the long-term durability and clinical efficacy of this stent. The use of drug-coated stents in the cerebrovascular circulation is an area that warrants further investigation.

AB - OBJECTIVE: Currently, there is minimal published data on the use of heparin-coated stents in the neurovasculature; however, these stents have a proven clinical record in the treatment of coronary disease. This article details our experience with the safety and technical aspects of stent deployment in the first 10 patients who had heparin-coated stents placed in the intracranial and cervical vasculature and the preliminary follow-up in most cases. METHODS: We retrospectively reviewed the clinical history, intra- and periprocedural data, and imaging for the patients who received heparin-coated stents in the cervical and intracranial vasculature for cerebrovascular disease between October 2002 and October 2003. RESULTS: Thirteen heparin-coated stents were placed in 10 patients. Seven out of the 10 patients had heparin-coated stents placed in the posterior circulation; the remaining three patients had stents placed in the anterior circulation. Four patients had stents placed intracranially. There was no acute or subacute in-stent thrombosis and no procedure-related complications. Follow-up was performed on most patients, with no clinical symptoms attributable to restenosis in any patient. CONCLUSION: This small series suggests that heparin-coated stents are safe for use in the treatment of cervical and intracranial atherosclerotic disease. Longer-term follow-up is needed to study the heparin coating effect on in-stent restenosis rates and to assess the long-term durability and clinical efficacy of this stent. The use of drug-coated stents in the cerebrovascular circulation is an area that warrants further investigation.

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