Use of fatty donor liver is associated with diminished early patient and graft survival

Willem A. Marsman, Russell H. Wiesner, Luis Rodriguez, Kenneth P. Batts, Michael K. Porayko, J. Eileen Hay, Gregory James Gores, Ruud A F Krom

Research output: Contribution to journalArticle

249 Citations (Scopus)

Abstract

It is well known that implantation of donor livers with severe fatty infiltration (>60%) is frequently associated with early hepatic dysfunction and an increased incidence of primary nonfunction after liver transplantation. The outcome of donor livers with less fatty infiltration has not been well defined. We, therefore, studied the outcome of 59 liver transplantations in which donor livers with up to 30% fat were used. Patient outcome was compared to a time-matched control group of 57 patients. The two groups were similar in terms of age, gender, preservation time, primary diagnosis, and UNOS status. We compared both groups with regard to 4-month and 2-year patient and graft survival. We also assessed the incidence of ischemic type biliary strictures and hepatic artery thrombosis, and evaluated the causes of graft loss in both groups. We found that use of donor livers with up to 30% fatty infiltration was associated with a significant decrease in 4-month graft survival (76% vs. 89%, P<0.05) and in 2-year patient survival (77% vs. 91%, P<0.05). Primary nonfunction and primary dysfunction formed the main cause of graft loss and mortality. Multivariate analysis showed that fatty infiltration is an independent predictive factor for outcome after transplantation. We conclude that liver allografts with up to 30% fat lead to diminished outcome after liver transplantation. However, this diminished outcome should be viewed with respect to the increasing mortality on the national waiting list.

Original languageEnglish (US)
Pages (from-to)1246-1251
Number of pages6
JournalTransplantation
Volume62
Issue number9
DOIs
StatePublished - Nov 15 1996

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Graft Survival
Fatty Liver
Tissue Donors
Liver
Liver Transplantation
Fats
Transplants
Waiting Lists
Mortality
Hepatic Artery
Incidence
Allografts
Pathologic Constriction
Thrombosis
Research Design
Multivariate Analysis
Transplantation
Control Groups
Survival

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Marsman, W. A., Wiesner, R. H., Rodriguez, L., Batts, K. P., Porayko, M. K., Hay, J. E., ... Krom, R. A. F. (1996). Use of fatty donor liver is associated with diminished early patient and graft survival. Transplantation, 62(9), 1246-1251. https://doi.org/10.1097/00007890-199611150-00011

Use of fatty donor liver is associated with diminished early patient and graft survival. / Marsman, Willem A.; Wiesner, Russell H.; Rodriguez, Luis; Batts, Kenneth P.; Porayko, Michael K.; Hay, J. Eileen; Gores, Gregory James; Krom, Ruud A F.

In: Transplantation, Vol. 62, No. 9, 15.11.1996, p. 1246-1251.

Research output: Contribution to journalArticle

Marsman, WA, Wiesner, RH, Rodriguez, L, Batts, KP, Porayko, MK, Hay, JE, Gores, GJ & Krom, RAF 1996, 'Use of fatty donor liver is associated with diminished early patient and graft survival', Transplantation, vol. 62, no. 9, pp. 1246-1251. https://doi.org/10.1097/00007890-199611150-00011
Marsman WA, Wiesner RH, Rodriguez L, Batts KP, Porayko MK, Hay JE et al. Use of fatty donor liver is associated with diminished early patient and graft survival. Transplantation. 1996 Nov 15;62(9):1246-1251. https://doi.org/10.1097/00007890-199611150-00011
Marsman, Willem A. ; Wiesner, Russell H. ; Rodriguez, Luis ; Batts, Kenneth P. ; Porayko, Michael K. ; Hay, J. Eileen ; Gores, Gregory James ; Krom, Ruud A F. / Use of fatty donor liver is associated with diminished early patient and graft survival. In: Transplantation. 1996 ; Vol. 62, No. 9. pp. 1246-1251.
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