TY - JOUR
T1 - Use of DOTATATE PET/CT scan in the diagnosis and staging of thymic atypical carcinoid tumor in a patient with secondary ACTH-dependent cushing syndrome
T2 - Look twice and cut once
AU - Agzarian, John
AU - Quandeel, Hisham
AU - Bancos, Irina
AU - Johnson, Geoffrey B.
AU - Scharf, Stephen C.
AU - Thompson, Geoffrey B.
AU - Yi, Joanne
AU - Zhang, Xiaotun
AU - Shen, K. Robert
N1 - Publisher Copyright:
© 2018, Jaypee Brothers Medical Publishers (P) Ltd. All rights reserved.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Neuroendocrine thymic tumors represent the least common type of primary thymic tumor with a prevalence of 2 to 5%. We present a case of locally advanced thymic atypical carcinoid tumor diagnosed incidentally while investigating progressive Cushing syndrome. Computed tomography (CT) scan demonstrated a large 2.9 cm exophytic thyroid nodule and a 2.0 cm anterior mediastinal mass. Biopsy of the thyroid nodule demonstrated benign thyroid tissue, and octreotide scan revealed avid uptake in the right thyroid lobe with minimal uptake in the thymic tumor.68Gallium-1,4,7,10-tetraazacyclododecane-N,N′,N″N′″-tetraacetic acid-D-Phe1,Tyr3-octreotate (Ga-68 DOTATATE) positron emission tomography (PET)/CT scan showed intense uptake in the thyroid gland followed by a moderate amount of activity in the anterior mediastinal mass. The patient underwent a median sternotomy and radical thymectomy with en bloc resection of the left innominate vein and primary repair of the superior vena cava (SVC). On further evaluation, the presumed thyroid nodule appeared contiguous with the thymic lesion and separate from the thyroid. Final pathology demonstrated a poorly differentiated 4.4 cm atypical carcinoid tumor with nine positive lymph nodes. On the third postoperative day, the serum cortisol level precipitously decreased to a level of 6.8 µg/dL. This case highlights the challenges surrounding the diagnosis of hormonally active thymic carcinoids and demonstrates the utility of Ga-68 DOTATATE PET scan in localizing somatostatin-positive neuroendocrine tumors and surgical planning.
AB - Neuroendocrine thymic tumors represent the least common type of primary thymic tumor with a prevalence of 2 to 5%. We present a case of locally advanced thymic atypical carcinoid tumor diagnosed incidentally while investigating progressive Cushing syndrome. Computed tomography (CT) scan demonstrated a large 2.9 cm exophytic thyroid nodule and a 2.0 cm anterior mediastinal mass. Biopsy of the thyroid nodule demonstrated benign thyroid tissue, and octreotide scan revealed avid uptake in the right thyroid lobe with minimal uptake in the thymic tumor.68Gallium-1,4,7,10-tetraazacyclododecane-N,N′,N″N′″-tetraacetic acid-D-Phe1,Tyr3-octreotate (Ga-68 DOTATATE) positron emission tomography (PET)/CT scan showed intense uptake in the thyroid gland followed by a moderate amount of activity in the anterior mediastinal mass. The patient underwent a median sternotomy and radical thymectomy with en bloc resection of the left innominate vein and primary repair of the superior vena cava (SVC). On further evaluation, the presumed thyroid nodule appeared contiguous with the thymic lesion and separate from the thyroid. Final pathology demonstrated a poorly differentiated 4.4 cm atypical carcinoid tumor with nine positive lymph nodes. On the third postoperative day, the serum cortisol level precipitously decreased to a level of 6.8 µg/dL. This case highlights the challenges surrounding the diagnosis of hormonally active thymic carcinoids and demonstrates the utility of Ga-68 DOTATATE PET scan in localizing somatostatin-positive neuroendocrine tumors and surgical planning.
KW - DOTATATE
KW - Mediastinal
KW - Positron emission tomography
KW - Thymic carcinoid
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U2 - 10.5005/jp-journals-10002-1231
DO - 10.5005/jp-journals-10002-1231
M3 - Article
AN - SCOPUS:85052202794
SN - 0975-5039
VL - 10
SP - 127
EP - 133
JO - World Journal of Endocrine Surgery
JF - World Journal of Endocrine Surgery
IS - 2
ER -