Use of diuretics is associated with reduced risk of Alzheimer's disease: The Cache County study

Cache County Investigators

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Although the use of antihypertensive medications has been associated with reduced risk of Alzheimer's disease (AD), it remains unclear which class provides the most benefit. The Cache County Study of Memory Health and Aging is a prospective longitudinal cohort study of dementing illnesses among the elderly population of Cache County, Utah. Using waves I to IV data of the Cache County Study, 3417 participants had a mean of 7.1years of follow-up. Time-varying use of antihypertensive medications including different class of diuretics, angiotensin converting enzyme inhibitors, β-blockers, and calcium channel blockers was used to predict the incidence of AD using Cox proportional hazards analyses. During follow-up, 325 AD cases were ascertained with a total of 23,590 person-years. Use of any antihypertensive medication was associated with lower incidence of AD (adjusted hazard ratio [aHR], 0.77; 95% confidence interval [CI], 0.61-0.97). Among different classes of antihypertensive medications, thiazide (aHR, 0.7; 95% CI, 0.53-0.93), and potassium-sparing diuretics (aHR, 0.69; 95% CI, 0.48-0.99) were associated with the greatest reduction of AD risk. Thiazide and potassium-sparing diuretics were associated with decreased risk of AD. The inverse association of potassium-sparing diuretics confirms an earlier finding in this cohort, now with longer follow-up, and merits further investigation.

Original languageEnglish (US)
Pages (from-to)2429-2435
Number of pages7
JournalNeurobiology of Aging
Volume35
Issue number11
DOIs
StatePublished - Nov 1 2014

Fingerprint

Diuretics
Alzheimer Disease
Potassium Sparing Diuretics
Antihypertensive Agents
Thiazides
Confidence Intervals
Incidence
Calcium Channel Blockers
Angiotensin-Converting Enzyme Inhibitors
Longitudinal Studies
Cohort Studies
Health
Population

Keywords

  • Alzheimer's disease
  • Antihypertensive medications
  • Diuretics

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Use of diuretics is associated with reduced risk of Alzheimer's disease : The Cache County study. / Cache County Investigators.

In: Neurobiology of Aging, Vol. 35, No. 11, 01.11.2014, p. 2429-2435.

Research output: Contribution to journalArticle

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abstract = "Although the use of antihypertensive medications has been associated with reduced risk of Alzheimer's disease (AD), it remains unclear which class provides the most benefit. The Cache County Study of Memory Health and Aging is a prospective longitudinal cohort study of dementing illnesses among the elderly population of Cache County, Utah. Using waves I to IV data of the Cache County Study, 3417 participants had a mean of 7.1years of follow-up. Time-varying use of antihypertensive medications including different class of diuretics, angiotensin converting enzyme inhibitors, β-blockers, and calcium channel blockers was used to predict the incidence of AD using Cox proportional hazards analyses. During follow-up, 325 AD cases were ascertained with a total of 23,590 person-years. Use of any antihypertensive medication was associated with lower incidence of AD (adjusted hazard ratio [aHR], 0.77; 95{\%} confidence interval [CI], 0.61-0.97). Among different classes of antihypertensive medications, thiazide (aHR, 0.7; 95{\%} CI, 0.53-0.93), and potassium-sparing diuretics (aHR, 0.69; 95{\%} CI, 0.48-0.99) were associated with the greatest reduction of AD risk. Thiazide and potassium-sparing diuretics were associated with decreased risk of AD. The inverse association of potassium-sparing diuretics confirms an earlier finding in this cohort, now with longer follow-up, and merits further investigation.",
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