TY - JOUR
T1 - Use of copeptin for rapid rule-out of acute myocardial infarction
AU - the ESC Study Group on Biomarkers in Cardiology of the Acute Cardiovascular Care Association
AU - Mueller, Christian
AU - Möckel, Martin
AU - Giannitsis, Evangelos
AU - Huber, Kurt
AU - Mair, Johannes
AU - Plebani, Mario
AU - Thygesen, Kristian
AU - Jaffe, Allan S.
AU - Lindahl, Bertil
N1 - Publisher Copyright:
© The European Society of Cardiology 2017.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Copeptin is currently understood as a quantitative marker of endogenous stress. It rises rapidly in multiple acute disorders including acute myocardial infarction. As a single variable, it has only modest diagnostic accuracy for acute myocardial infarction. However, the use of copeptin within a dual-marker strategy together with conventional cardiac troponin increases the diagnostic accuracy and particularly the negative predictive value of cardiac troponin alone for acute myocardial infarction. The rapid rule-out of acute myocardial infarction is the only application in acute cardiac care mature enough to merit consideration for routine clinical care. However, the dual-marker approach seems to provide only very small incremental value when used in combination with sensitive or high-sensitivity cardiac troponin assays. This review aims to update and educate regarding the potential and the procedural details, as well as the caveats and challenges of using copeptin in clinical practice.
AB - Copeptin is currently understood as a quantitative marker of endogenous stress. It rises rapidly in multiple acute disorders including acute myocardial infarction. As a single variable, it has only modest diagnostic accuracy for acute myocardial infarction. However, the use of copeptin within a dual-marker strategy together with conventional cardiac troponin increases the diagnostic accuracy and particularly the negative predictive value of cardiac troponin alone for acute myocardial infarction. The rapid rule-out of acute myocardial infarction is the only application in acute cardiac care mature enough to merit consideration for routine clinical care. However, the dual-marker approach seems to provide only very small incremental value when used in combination with sensitive or high-sensitivity cardiac troponin assays. This review aims to update and educate regarding the potential and the procedural details, as well as the caveats and challenges of using copeptin in clinical practice.
KW - Acute myocardial infarction
KW - diagnosis
KW - rule-out
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U2 - 10.1177/2048872617710791
DO - 10.1177/2048872617710791
M3 - Review article
C2 - 28593800
AN - SCOPUS:85028522633
SN - 2048-8726
VL - 7
SP - 570
EP - 576
JO - European Heart Journal: Acute Cardiovascular Care
JF - European Heart Journal: Acute Cardiovascular Care
IS - 6
ER -