Abstract
In patients with Crohn's disease (CD), anti–tumor necrosis factor (TNF) therapy is efficacious for the induction and maintenance of clinical remission, mucosal healing, reducing rates of surgery and hospitalizations, and improving health-related quality of life. The decision between anti-TNFs and anti-integrins as first-line treatment in CD depends on disease severity, safety concerns, and prescription coverage. Given the existing data on long-term outcomes and safety, anti-TNFs are often preferred to anti-integrins. Additional clinical experience and preferably prospective, head-to-head studies will be important to determine whether vedolizumab should be considered more often for first-line therapy in CD.
Original language | English (US) |
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Pages (from-to) | 589-601 |
Number of pages | 13 |
Journal | Gastroenterology Clinics of North America |
Volume | 46 |
Issue number | 3 |
DOIs | |
State | Published - Sep 2017 |
Keywords
- Anti-TNFs
- Anti-integrins
- Biologics
- Crohn's disease
- Treatment
ASJC Scopus subject areas
- Gastroenterology