Usability and acceptability of a web-based program for chemotherapy-induced peripheral neuropathy

Cindy Tofthagen, Kevin E. Kip, Denise Passmore, Ian Loy, Donna L. Berry

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Chemotherapy-induced neuropathy is a painful and debilitating adverse effect of certain chemotherapy drugs. There have not been any patient-centered, easily accessible Web-based interventions to assist with self-management of chemotherapy-induced neuropathy. The aims of this study were to evaluate usability and acceptability and to estimate an effect size of a Web-based intervention for assessing and managing chemotherapy-induced neuropathy. Participants (N = 14) were instructed to complete the Creativity, Optimism, Planning, and Expert Information for Chemotherapy-Induced Peripheral Neuropathy program and provide verbal responses to the program. Participants completed the Chemotherapy Induced Peripheral Neuropathy Assessment Tool and Post-Study System Usability Questionnaire. Iterative changes were made to the COPE-CIPN. Participants were asked to provide feedback on the revised COPECIPN, repeat the Chemotherapy Induced Peripheral Neuropathy Assessment Tool, and evaluate acceptability using the Acceptability e-Scale. The COPE-CIPN demonstrated high usability (mean, 1.98 [SD, 1.12]) and acceptability (mean, 4.40 [SD, 0.52]). Comments indicated that the interface was easy to use, and the information was helpful. While neuropathy symptoms continued to increase in this group of patients receiving neurotoxic chemotherapy, there was a decrease in mean level of interference with activities from 53.71 to 39.29 over 3 to 4 months, which indicated a moderate effect (d = 0.39) size. The COPE-CIPN may be a useful intervention to support self-management of chemotherapy-induced neuropathy.

Original languageEnglish (US)
Pages (from-to)322-329
Number of pages8
JournalCIN - Computers Informatics Nursing
Issue number7
StatePublished - Aug 17 2016
Externally publishedYes


  • Antineoplastic agents
  • Antitumor drugs
  • Neuropathy
  • Painful

ASJC Scopus subject areas

  • Health Informatics
  • Nursing (miscellaneous)


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