US Immigration Westernizes the Human Gut Microbiome

Pajau Vangay, Abigail J. Johnson, Tonya L. Ward, Gabriel A. Al-Ghalith, Robin R. Shields-Cutler, Benjamin M. Hillmann, Sarah K. Lucas, Lalit K. Beura, Emily A. Thompson, Lisa M. Till, Rodolfo Batres, Bwei Paw, Shannon L. Pergament, Pimpanitta Saenyakul, Mary Xiong, Austin D. Kim, Grant Kim, David Masopust, Eric C. Martens, Chaisiri AngkurawaranonRose McGready, Purna C Kashyap, Kathleen A. Culhane-Pera, Dan Knights

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Many US immigrant populations develop metabolic diseases post immigration, but the causes are not well understood. Although the microbiome plays a role in metabolic disease, there have been no studies measuring the effects of US immigration on the gut microbiome. We collected stool, dietary recalls, and anthropometrics from 514 Hmong and Karen individuals living in Thailand and the United States, including first- and second-generation immigrants and 19 Karen individuals sampled before and after immigration, as well as from 36 US-born European American individuals. Using 16S and deep shotgun metagenomic DNA sequencing, we found that migration from a non-Western country to the United States is associated with immediate loss of gut microbiome diversity and function in which US-associated strains and functions displace native strains and functions. These effects increase with duration of US residence and are compounded by obesity and across generations. Migration from a non-western nation to the United States is found to be associated with a loss in gut microbiome diversity and function in a manner that may predispose individuals to metabolic disease.

Original languageEnglish (US)
Pages (from-to)962-972.e10
JournalCell
Volume175
Issue number4
DOIs
StatePublished - Nov 1 2018

Fingerprint

Microbiota
Metabolic Diseases
Emigration and Immigration
Metagenomics
Firearms
Thailand
DNA Sequence Analysis
Obesity
Population
Gastrointestinal Microbiome
DNA

Keywords

  • Bacteriodes
  • immigrant health
  • immigration
  • metagenomics
  • microbiome
  • microbiota
  • obesity
  • Prevotella
  • refugee health

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Vangay, P., Johnson, A. J., Ward, T. L., Al-Ghalith, G. A., Shields-Cutler, R. R., Hillmann, B. M., ... Knights, D. (2018). US Immigration Westernizes the Human Gut Microbiome. Cell, 175(4), 962-972.e10. https://doi.org/10.1016/j.cell.2018.10.029

US Immigration Westernizes the Human Gut Microbiome. / Vangay, Pajau; Johnson, Abigail J.; Ward, Tonya L.; Al-Ghalith, Gabriel A.; Shields-Cutler, Robin R.; Hillmann, Benjamin M.; Lucas, Sarah K.; Beura, Lalit K.; Thompson, Emily A.; Till, Lisa M.; Batres, Rodolfo; Paw, Bwei; Pergament, Shannon L.; Saenyakul, Pimpanitta; Xiong, Mary; Kim, Austin D.; Kim, Grant; Masopust, David; Martens, Eric C.; Angkurawaranon, Chaisiri; McGready, Rose; Kashyap, Purna C; Culhane-Pera, Kathleen A.; Knights, Dan.

In: Cell, Vol. 175, No. 4, 01.11.2018, p. 962-972.e10.

Research output: Contribution to journalArticle

Vangay, P, Johnson, AJ, Ward, TL, Al-Ghalith, GA, Shields-Cutler, RR, Hillmann, BM, Lucas, SK, Beura, LK, Thompson, EA, Till, LM, Batres, R, Paw, B, Pergament, SL, Saenyakul, P, Xiong, M, Kim, AD, Kim, G, Masopust, D, Martens, EC, Angkurawaranon, C, McGready, R, Kashyap, PC, Culhane-Pera, KA & Knights, D 2018, 'US Immigration Westernizes the Human Gut Microbiome', Cell, vol. 175, no. 4, pp. 962-972.e10. https://doi.org/10.1016/j.cell.2018.10.029
Vangay P, Johnson AJ, Ward TL, Al-Ghalith GA, Shields-Cutler RR, Hillmann BM et al. US Immigration Westernizes the Human Gut Microbiome. Cell. 2018 Nov 1;175(4):962-972.e10. https://doi.org/10.1016/j.cell.2018.10.029
Vangay, Pajau ; Johnson, Abigail J. ; Ward, Tonya L. ; Al-Ghalith, Gabriel A. ; Shields-Cutler, Robin R. ; Hillmann, Benjamin M. ; Lucas, Sarah K. ; Beura, Lalit K. ; Thompson, Emily A. ; Till, Lisa M. ; Batres, Rodolfo ; Paw, Bwei ; Pergament, Shannon L. ; Saenyakul, Pimpanitta ; Xiong, Mary ; Kim, Austin D. ; Kim, Grant ; Masopust, David ; Martens, Eric C. ; Angkurawaranon, Chaisiri ; McGready, Rose ; Kashyap, Purna C ; Culhane-Pera, Kathleen A. ; Knights, Dan. / US Immigration Westernizes the Human Gut Microbiome. In: Cell. 2018 ; Vol. 175, No. 4. pp. 962-972.e10.
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