Urticaria and angioedema from cyclooxygenase-2 inhibitors

P. S. Kelkar, J. H. Butterfield, H. G. Teaford

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Cyclooxygenase-2 (COX-2) inhibitors celecoxib and rofecoxib have generally been well tolerated. It has been unclear if specific COX-2 inhibitors would cross react with acetylsalicylic acid and typical nonsteroidal antiinflammatory drugs to cause urticaria or angioedema. There are no reports in the literature of hives or angioedema resulting from their use. We describe 3 patients who developed urticaria and/or angioedema from COX-2 inhibitors. With the increasing use of COX-2 inhibitors, one needs to be aware of these side effects and of possible cross reactivity between celecoxib and rofecoxib.

Original languageEnglish (US)
Pages (from-to)2553-2554
Number of pages2
JournalJournal of Rheumatology
Volume28
Issue number11
StatePublished - Nov 15 2001

Keywords

  • Angioedema
  • Cyclooxygenase-2 inhibitors
  • Urticaria

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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    Kelkar, P. S., Butterfield, J. H., & Teaford, H. G. (2001). Urticaria and angioedema from cyclooxygenase-2 inhibitors. Journal of Rheumatology, 28(11), 2553-2554.