Urine 4-(methylnitrosamino)-1-(3) pyridyl-1-butanol and cotinine in Alaska native postpartum women and neonates comparing smokers and smokeless tobacco users

Neal L. Benowitz, Christie A. Flanagan, Timothy K. Thomas, Kathryn R. Koller, Abbie W. Wolfe, Caroline C. Renner, Christine Hughes, Paul A. Decker, Dorothy K. Hatsukami, Neil J. Murphy, Christi Ann Patten

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: Foetuses and neonates of women who use tobacco are exposed to nicotine and tobacco-derived carcinogens. We determined the relationship between urine biomarkers of tobacco toxicant exposure postpartum and in the neonates of Alaska Native (AN) women, comparing smokers and smokeless tobacco (ST) users, including iqmik, a homemade ST product. Methods: AN women, including 36 smokers, 9 commercial ST and 16 iqmik users their neonates participated. Urine from the woman at the time of delivery and her neonate’s first urine were analysed for cotinine, the major metabolite of nicotine, and 4-(methylnitrosamino)-1-(3) pyridyl-1-butanol (NNAL), a tobacco-specific carcinogen biomarker. Results: Maternal urine cotinine and neonatal urine cotinine were strongly correlated in all tobacco use groups (r from 0.83 to 0.9, p < 0.002). Correlations between maternal cotinine and neonatal NNAL were moderately strong for cigarettes and commercial smokeless but weaker for iqmik users (r 0.73, 0.6 and 0.36, respectively). Conclusion: Correlations between maternal and neonatal biomarkers of tobacco toxicant exposure vary, dependent on tobacco product use. Significance: This study provides novel data on biomarkers of tobacco exposure among postpartum AN women and their neonates. The results could be useful to guide future epidemiological studies of health risks associated with use of various tobacco products during pregnancy.

Original languageEnglish (US)
Article number1528125
JournalInternational Journal of Circumpolar Health
Volume77
Issue number1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Smokeless Tobacco
Cotinine
Postpartum Period
nicotine
Tobacco
Tobacco Products
Urine
Newborn Infant
Tobacco Use
Biomarkers
Mothers
Nicotine
Carcinogens
Lobeline
Epidemiologic Studies
Fetus
4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol
Alaska Natives
Pregnancy
Health

Keywords

  • Biomarkers
  • carcinogens
  • cigarette smoking
  • neonate
  • pregnancy

ASJC Scopus subject areas

  • Epidemiology
  • Health(social science)
  • Public Health, Environmental and Occupational Health

Cite this

Urine 4-(methylnitrosamino)-1-(3) pyridyl-1-butanol and cotinine in Alaska native postpartum women and neonates comparing smokers and smokeless tobacco users. / Benowitz, Neal L.; Flanagan, Christie A.; Thomas, Timothy K.; Koller, Kathryn R.; Wolfe, Abbie W.; Renner, Caroline C.; Hughes, Christine; Decker, Paul A.; Hatsukami, Dorothy K.; Murphy, Neil J.; Patten, Christi Ann.

In: International Journal of Circumpolar Health, Vol. 77, No. 1, 1528125, 01.01.2018.

Research output: Contribution to journalArticle

Benowitz, Neal L. ; Flanagan, Christie A. ; Thomas, Timothy K. ; Koller, Kathryn R. ; Wolfe, Abbie W. ; Renner, Caroline C. ; Hughes, Christine ; Decker, Paul A. ; Hatsukami, Dorothy K. ; Murphy, Neil J. ; Patten, Christi Ann. / Urine 4-(methylnitrosamino)-1-(3) pyridyl-1-butanol and cotinine in Alaska native postpartum women and neonates comparing smokers and smokeless tobacco users. In: International Journal of Circumpolar Health. 2018 ; Vol. 77, No. 1.
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abstract = "Objective: Foetuses and neonates of women who use tobacco are exposed to nicotine and tobacco-derived carcinogens. We determined the relationship between urine biomarkers of tobacco toxicant exposure postpartum and in the neonates of Alaska Native (AN) women, comparing smokers and smokeless tobacco (ST) users, including iqmik, a homemade ST product. Methods: AN women, including 36 smokers, 9 commercial ST and 16 iqmik users their neonates participated. Urine from the woman at the time of delivery and her neonate’s first urine were analysed for cotinine, the major metabolite of nicotine, and 4-(methylnitrosamino)-1-(3) pyridyl-1-butanol (NNAL), a tobacco-specific carcinogen biomarker. Results: Maternal urine cotinine and neonatal urine cotinine were strongly correlated in all tobacco use groups (r from 0.83 to 0.9, p < 0.002). Correlations between maternal cotinine and neonatal NNAL were moderately strong for cigarettes and commercial smokeless but weaker for iqmik users (r 0.73, 0.6 and 0.36, respectively). Conclusion: Correlations between maternal and neonatal biomarkers of tobacco toxicant exposure vary, dependent on tobacco product use. Significance: This study provides novel data on biomarkers of tobacco exposure among postpartum AN women and their neonates. The results could be useful to guide future epidemiological studies of health risks associated with use of various tobacco products during pregnancy.",
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AU - Thomas, Timothy K.

AU - Koller, Kathryn R.

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AU - Renner, Caroline C.

AU - Hughes, Christine

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AB - Objective: Foetuses and neonates of women who use tobacco are exposed to nicotine and tobacco-derived carcinogens. We determined the relationship between urine biomarkers of tobacco toxicant exposure postpartum and in the neonates of Alaska Native (AN) women, comparing smokers and smokeless tobacco (ST) users, including iqmik, a homemade ST product. Methods: AN women, including 36 smokers, 9 commercial ST and 16 iqmik users their neonates participated. Urine from the woman at the time of delivery and her neonate’s first urine were analysed for cotinine, the major metabolite of nicotine, and 4-(methylnitrosamino)-1-(3) pyridyl-1-butanol (NNAL), a tobacco-specific carcinogen biomarker. Results: Maternal urine cotinine and neonatal urine cotinine were strongly correlated in all tobacco use groups (r from 0.83 to 0.9, p < 0.002). Correlations between maternal cotinine and neonatal NNAL were moderately strong for cigarettes and commercial smokeless but weaker for iqmik users (r 0.73, 0.6 and 0.36, respectively). Conclusion: Correlations between maternal and neonatal biomarkers of tobacco toxicant exposure vary, dependent on tobacco product use. Significance: This study provides novel data on biomarkers of tobacco exposure among postpartum AN women and their neonates. The results could be useful to guide future epidemiological studies of health risks associated with use of various tobacco products during pregnancy.

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