Urinary Tract Anomalies Detected by Prenatal Ultrasound Examination at Mayo Clinic Rochester

James M. Gloor, Paul L. Ogburn, Robert J. Breckle, Bruce Z. Morgenstern, Dawn S. Milliner

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

To determine the frequency of fetal urinary tract anomalies and to characterize the types of such abnormalities detected on ultrasonography and the outcome of affected patients during a 15-year period at our institution. We retrospectively reviewed the findings on maternal prenatal ultrasound examinations and the postnatal medical records of 56 children with urinary tract abnormalities detected by prenatal ultrasound examination at Mayo Clinic Rochester from November 1979 to June 1994. Of the 56 children, 18 (32 %) had severe urinary tract anomalies in conjunction with oligohydramnios, pulmonary hypoplasia, and perinatal death (Potter's syndrome). The other 38 infants had various urinary tract abnormalities—most commonly, isolated hydronephrosis and multicystic dysplasia of the kidney. Six of the 38 children had more than one renal abnormality detected prenatally. Reflux was noted in association with prenatally detected urinary tract abnormalities in 4 of 32 newborns (12 %) who underwent voiding cystourethrography. In fetuses with normal amniotic fluid volume, the perinatal outcome was good. Children with lower urinary tract obstruction had evidence of more severe renal dysfunction than did those with involvement at more proximal levels. The presence or absence of urinary tract obstruction postnatally could not be determined reliably on the basis of prenatal ultrasound appearance. In this study, more than half of all prenatally detected urinary tract abnormalities were isolated hydronephrosis or multicystic dysplasia or the kidney. Postnatal renal function could not be reliably predicted on the basis of prenatal ultrasound findings.

Original languageEnglish (US)
Pages (from-to)526-531
Number of pages6
JournalMayo Clinic proceedings
Volume70
Issue number6
DOIs
StatePublished - Jan 1 1995

Keywords

  • DMSA
  • DTPA
  • MAG
  • MCDK
  • diethylenetriamine pentaacetic acid
  • dimercaptosuccinic acid
  • mercaptoacetyltriglycine
  • multicystic dysplasia of the kidney

ASJC Scopus subject areas

  • Medicine(all)

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    Gloor, J. M., Ogburn, P. L., Breckle, R. J., Morgenstern, B. Z., & Milliner, D. S. (1995). Urinary Tract Anomalies Detected by Prenatal Ultrasound Examination at Mayo Clinic Rochester. Mayo Clinic proceedings, 70(6), 526-531. https://doi.org/10.4065/70.6.526