Urinary proteomic profiling for diagnostic bladder cancer biomarkers

Steve Goodison, Charles J. Rosser, Virginia Urquidi

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

The ability to detect and monitor bladder cancer in noninvasively obtained urine samples is a major goal. While a number of protein biomarkers have been identified and commercially developed, none have greatly improved the accuracy of sample evaluation over invasive cystoscopy. The ongoing development of high-throughput proteomic profiling technologies will facilitate the identification of molecular signatures that are associated with bladder disease. The appropriate use of these approaches has the potential to provide efficient biomarkers for the early detection and monitoring of recurrent bladder cancer. Identification of disease-associated proteins will also advance our knowledge of tumor biology, which, in turn, will enable development of targeted therapeutics aimed at reducing morbidity from bladder cancer. In this article, we focus on the accumulating proteomic signatures of urine in health and disease, and discuss expected future developments in this field of research.

Original languageEnglish (US)
Pages (from-to)507-514
Number of pages8
JournalExpert Review of Proteomics
Volume6
Issue number5
DOIs
StatePublished - Oct 1 2009

Keywords

  • Biomarker
  • Bladder cancer detection
  • Molecular signature
  • Oncoproteomics
  • Urinalysis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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