Urinary podocyte excretion as a marker for preeclampsia

Vesna D. Garovic; Steven J. Wagner; Stephen T. Turner; David W. Rosenthal; William J. Watson; Brian C. Brost; Carl H. Rose; Larisa Gavrilova; Paula Craigo; Kent R. Bailey; Johannes Achenbach; Mario Schiffer; Joseph P. Grande

doi:10.1016/j.ajog.2007.02.007

Urinary podocyte excretion as a marker for preeclampsia

Vesna D. Garovic, Steven J. Wagner, Stephen T. Turner, David W. Rosenthal, William J. Watson, Brian C. Brost, Carl H. Rose, Larisa Gavrilova, Paula Craigo, Kent R. Bailey, Johannes Achenbach, Mario Schiffer, Joseph P. Grande

Research output: Contribution to journal › Article › peer-review

140 Scopus citations

Abstract

Objective: The objective of this study was to examine whether podocyturia, which is the urinary excretion of viable podocytes (glomerular epithelial cells), is present in urinary sediments of patients with preeclampsia. We also aimed to compare the test characteristics of podocyturia to those angiogenic factors that have been shown to play an important role in the pathogenesis of preeclampsia (s-Flt-1, PlGF, and endoglin). Study Design: Serum angiogenic factors were measured in 44 patients with preeclampsia and 23 normotensive control patients. In a patient subset (15 cases and 16 control patients), urinary proteinuria were identified and quantified on the basis of their expressions of podocyte-specific proteins. Results: Urinary podocyte excretion occurred in all patients with preeclampsia. The positive predictive value for the diagnosis of preeclampsia was greater for podocyturia than for any of the measured angiogenic factors. Conclusion: Podocyturia is a highly sensitive and specific marker for preeclampsia. It may contribute to the development of proteinuria in preeclampsia.

Original language	English (US)
Pages (from-to)	320.e1-320.e7
Journal	American journal of obstetrics and gynecology
Volume	196
Issue number	4
DOIs	https://doi.org/10.1016/j.ajog.2007.02.007
State	Published - Apr 2007

Keywords

podocyte
podocyturia
preeclampsia

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/j.ajog.2007.02.007

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Garovic, V. D., Wagner, S. J., Turner, S. T., Rosenthal, D. W., Watson, W. J., Brost, B. C., Rose, C. H., Gavrilova, L., Craigo, P., Bailey, K. R., Achenbach, J., Schiffer, M., & Grande, J. P. (2007). Urinary podocyte excretion as a marker for preeclampsia. American journal of obstetrics and gynecology, 196(4), 320.e1-320.e7. https://doi.org/10.1016/j.ajog.2007.02.007

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abstract = "Objective: The objective of this study was to examine whether podocyturia, which is the urinary excretion of viable podocytes (glomerular epithelial cells), is present in urinary sediments of patients with preeclampsia. We also aimed to compare the test characteristics of podocyturia to those angiogenic factors that have been shown to play an important role in the pathogenesis of preeclampsia (s-Flt-1, PlGF, and endoglin). Study Design: Serum angiogenic factors were measured in 44 patients with preeclampsia and 23 normotensive control patients. In a patient subset (15 cases and 16 control patients), urinary proteinuria were identified and quantified on the basis of their expressions of podocyte-specific proteins. Results: Urinary podocyte excretion occurred in all patients with preeclampsia. The positive predictive value for the diagnosis of preeclampsia was greater for podocyturia than for any of the measured angiogenic factors. Conclusion: Podocyturia is a highly sensitive and specific marker for preeclampsia. It may contribute to the development of proteinuria in preeclampsia.",

keywords = "podocyte, podocyturia, preeclampsia",

author = "Garovic, {Vesna D.} and Wagner, {Steven J.} and Turner, {Stephen T.} and Rosenthal, {David W.} and Watson, {William J.} and Brost, {Brian C.} and Rose, {Carl H.} and Larisa Gavrilova and Paula Craigo and Bailey, {Kent R.} and Johannes Achenbach and Mario Schiffer and Grande, {Joseph P.}",

year = "2007",

month = apr,

doi = "10.1016/j.ajog.2007.02.007",

language = "English (US)",

volume = "196",

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T1 - Urinary podocyte excretion as a marker for preeclampsia

AU - Garovic, Vesna D.

AU - Wagner, Steven J.

AU - Turner, Stephen T.

AU - Rosenthal, David W.

AU - Watson, William J.

AU - Brost, Brian C.

AU - Rose, Carl H.

AU - Gavrilova, Larisa

AU - Craigo, Paula

AU - Bailey, Kent R.

AU - Achenbach, Johannes

AU - Schiffer, Mario

AU - Grande, Joseph P.

PY - 2007/4

Y1 - 2007/4

N2 - Objective: The objective of this study was to examine whether podocyturia, which is the urinary excretion of viable podocytes (glomerular epithelial cells), is present in urinary sediments of patients with preeclampsia. We also aimed to compare the test characteristics of podocyturia to those angiogenic factors that have been shown to play an important role in the pathogenesis of preeclampsia (s-Flt-1, PlGF, and endoglin). Study Design: Serum angiogenic factors were measured in 44 patients with preeclampsia and 23 normotensive control patients. In a patient subset (15 cases and 16 control patients), urinary proteinuria were identified and quantified on the basis of their expressions of podocyte-specific proteins. Results: Urinary podocyte excretion occurred in all patients with preeclampsia. The positive predictive value for the diagnosis of preeclampsia was greater for podocyturia than for any of the measured angiogenic factors. Conclusion: Podocyturia is a highly sensitive and specific marker for preeclampsia. It may contribute to the development of proteinuria in preeclampsia.

AB - Objective: The objective of this study was to examine whether podocyturia, which is the urinary excretion of viable podocytes (glomerular epithelial cells), is present in urinary sediments of patients with preeclampsia. We also aimed to compare the test characteristics of podocyturia to those angiogenic factors that have been shown to play an important role in the pathogenesis of preeclampsia (s-Flt-1, PlGF, and endoglin). Study Design: Serum angiogenic factors were measured in 44 patients with preeclampsia and 23 normotensive control patients. In a patient subset (15 cases and 16 control patients), urinary proteinuria were identified and quantified on the basis of their expressions of podocyte-specific proteins. Results: Urinary podocyte excretion occurred in all patients with preeclampsia. The positive predictive value for the diagnosis of preeclampsia was greater for podocyturia than for any of the measured angiogenic factors. Conclusion: Podocyturia is a highly sensitive and specific marker for preeclampsia. It may contribute to the development of proteinuria in preeclampsia.

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KW - podocyturia

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Urinary podocyte excretion as a marker for preeclampsia

Abstract

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