Urinary microRNA in kidney disease: utility and roles

In O. Sun, Lilach O Lerman

Research output: Contribution to journalArticle

Abstract

MicroRNAs (miRNAs) are small, noncoding single-stranded RNA oligonucleotides that modulate physiological and pathological processes by modulating target gene expression. Many miRNAs display tissue-specific expression patterns, the dysregulation of which has been associated with various disease states, including kidney disease. Mounting evidence implicates miRNAs in various biological processes, such as cell proliferation and differentiation and cancer. Because miRNAs are relatively stable in tissue and biological fluids, particularly when carried by extracellular vesicles, changes in their levels may reflect the development of human disease. Urinary miRNAs originate from primary kidney and urinary tract cells, cells infiltrating the renal tissue and shed in the urine, or the systemic circulation. Although their validity as biomarkers for kidney disease has not been fully established, studies have been applying analysis of miRNAs in the urine in an attempt to detect and monitor acute and chronic renal diseases. Because appreciation of the significance of miRNAs in the renal field is on the rise, an understanding of miRNA pathways that regulate renal physiology and pathophysiology is becoming critically important. This review aims to summarize new data obtained in this field of research. It is hoped that new developments in the use of miRNAs as biomarkers and/or therapy will help manage and contain kidney disease in affected subjects.

Original languageEnglish (US)
Pages (from-to)F785-F793
JournalAmerican journal of physiology. Renal physiology
Volume316
Issue number5
DOIs
StatePublished - May 1 2019

Fingerprint

Kidney Diseases
MicroRNAs
Kidney
Biomarkers
Urine
Physiological Phenomena
Biological Phenomena
Human Development
Pathologic Processes
Urinary Tract
Chronic Renal Insufficiency
Oligonucleotides
Cell Differentiation
Cell Proliferation
RNA
Gene Expression

Keywords

  • biomarkers
  • kidney
  • microRNAs
  • urine

ASJC Scopus subject areas

  • Physiology
  • Urology

Cite this

Urinary microRNA in kidney disease : utility and roles. / Sun, In O.; Lerman, Lilach O.

In: American journal of physiology. Renal physiology, Vol. 316, No. 5, 01.05.2019, p. F785-F793.

Research output: Contribution to journalArticle

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