Urinary collecting system invasion is associated with poor survival in patients with clear-cell renal cell carcinoma

George C. Bailey, Stephen A. Boorjian, Matthew J. Ziegelmann, Mary E. Westerman, Christine M. Lohse, Bradley C. Leibovich, John C. Cheville, R. Houston Thompson

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objectives: To evaluate the prognostic significance of urinary collecting system invasion (UCSI) in a large series of patients with clear-cell renal cell carcinoma (RCC). Materials and Methods: Patients with clear-cell RCC treated with nephrectomy between 2001 and 2010 were reviewed from a prospectively maintained registry. One urological pathologist re-reviewed all slides. Cancer-specific survival was estimated using the Kaplan–Meier method, and associations of UCSI with death from RCC were evaluated using Cox models. Results: Of the 859 patients with clear-cell RCC, 58 (6.8%) had UCSI. At last follow-up, 310 patients had died from RCC at a median of 1.8 years after surgery. The median follow-up for patients alive at last follow-up was 8.2 years. The estimated cancer-specific survival at 10 years after surgery for patients with UCSI was 17%, compared with 60% for patients without UCSI (P < 0.001). In a multivariable model, UCSI remained independently associated with an increased risk of death from RCC (hazard ratio 1.5; P = 0.018). Further, among patients with pT3 RCC, those with USCI had survival outcomes similar to those of patients with pT4 RCC. Conclusions: Collecting system invasion is associated with poor prognosis among patients with clear-cell RCC. If validated, consideration should be given to including UCSI in future staging systems.

Original languageEnglish (US)
Pages (from-to)585-590
Number of pages6
JournalBJU International
Volume119
Issue number4
DOIs
StatePublished - Apr 1 2017

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Renal Cell Carcinoma
Survival
Nephrectomy
Proportional Hazards Models
Registries
Neoplasms

Keywords

  • collecting system
  • prognosis
  • renal cell
  • staging
  • survival

ASJC Scopus subject areas

  • Urology

Cite this

Bailey, G. C., Boorjian, S. A., Ziegelmann, M. J., Westerman, M. E., Lohse, C. M., Leibovich, B. C., ... Thompson, R. H. (2017). Urinary collecting system invasion is associated with poor survival in patients with clear-cell renal cell carcinoma. BJU International, 119(4), 585-590. https://doi.org/10.1111/bju.13669

Urinary collecting system invasion is associated with poor survival in patients with clear-cell renal cell carcinoma. / Bailey, George C.; Boorjian, Stephen A.; Ziegelmann, Matthew J.; Westerman, Mary E.; Lohse, Christine M.; Leibovich, Bradley C.; Cheville, John C.; Thompson, R. Houston.

In: BJU International, Vol. 119, No. 4, 01.04.2017, p. 585-590.

Research output: Contribution to journalArticle

Bailey, GC, Boorjian, SA, Ziegelmann, MJ, Westerman, ME, Lohse, CM, Leibovich, BC, Cheville, JC & Thompson, RH 2017, 'Urinary collecting system invasion is associated with poor survival in patients with clear-cell renal cell carcinoma', BJU International, vol. 119, no. 4, pp. 585-590. https://doi.org/10.1111/bju.13669
Bailey GC, Boorjian SA, Ziegelmann MJ, Westerman ME, Lohse CM, Leibovich BC et al. Urinary collecting system invasion is associated with poor survival in patients with clear-cell renal cell carcinoma. BJU International. 2017 Apr 1;119(4):585-590. https://doi.org/10.1111/bju.13669
Bailey, George C. ; Boorjian, Stephen A. ; Ziegelmann, Matthew J. ; Westerman, Mary E. ; Lohse, Christine M. ; Leibovich, Bradley C. ; Cheville, John C. ; Thompson, R. Houston. / Urinary collecting system invasion is associated with poor survival in patients with clear-cell renal cell carcinoma. In: BJU International. 2017 ; Vol. 119, No. 4. pp. 585-590.
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