Urinary collecting system invasion is associated with poor survival in patients with clear-cell renal cell carcinoma

George C. Bailey, Stephen A. Boorjian, Matthew J. Ziegelmann, Mary E. Westerman, Christine M. Lohse, Bradley C. Leibovich, John C. Cheville, R. Houston Thompson

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Objectives: To evaluate the prognostic significance of urinary collecting system invasion (UCSI) in a large series of patients with clear-cell renal cell carcinoma (RCC). Materials and Methods: Patients with clear-cell RCC treated with nephrectomy between 2001 and 2010 were reviewed from a prospectively maintained registry. One urological pathologist re-reviewed all slides. Cancer-specific survival was estimated using the Kaplan–Meier method, and associations of UCSI with death from RCC were evaluated using Cox models. Results: Of the 859 patients with clear-cell RCC, 58 (6.8%) had UCSI. At last follow-up, 310 patients had died from RCC at a median of 1.8 years after surgery. The median follow-up for patients alive at last follow-up was 8.2 years. The estimated cancer-specific survival at 10 years after surgery for patients with UCSI was 17%, compared with 60% for patients without UCSI (P < 0.001). In a multivariable model, UCSI remained independently associated with an increased risk of death from RCC (hazard ratio 1.5; P = 0.018). Further, among patients with pT3 RCC, those with USCI had survival outcomes similar to those of patients with pT4 RCC. Conclusions: Collecting system invasion is associated with poor prognosis among patients with clear-cell RCC. If validated, consideration should be given to including UCSI in future staging systems.

Original languageEnglish (US)
Pages (from-to)585-590
Number of pages6
JournalBJU International
Volume119
Issue number4
DOIs
StatePublished - Apr 1 2017

Keywords

  • collecting system
  • prognosis
  • renal cell
  • staging
  • survival

ASJC Scopus subject areas

  • Urology

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    Bailey, G. C., Boorjian, S. A., Ziegelmann, M. J., Westerman, M. E., Lohse, C. M., Leibovich, B. C., Cheville, J. C., & Thompson, R. H. (2017). Urinary collecting system invasion is associated with poor survival in patients with clear-cell renal cell carcinoma. BJU International, 119(4), 585-590. https://doi.org/10.1111/bju.13669