TY - JOUR
T1 - Uric Acid
T2 - A Missing Link between Hypertensive Pregnancy Disorders and Future Cardiovascular Disease?
AU - Weissgerber, Tracey L.
AU - Milic, Natasa M.
AU - Turner, Stephen T.
AU - Asad, Reem A.
AU - Mosley, Thomas H.
AU - Kardia, Sharon L.R.
AU - Hanis, Craig L.
AU - Garovic, Vesna D.
N1 - Funding Information:
Grant Support: The work was supported by grants U01HL054481, U01HL054471, U01HL054512, and U01HL054498 from the National Heart, Lung, and Blood Institute and the National Institutes of Health (NIH). The project described was supported by award number P-50 AG44170 (V.D.G.) from the National Institute on Aging ; Building Interdisciplinary Careers in Women’s Health award K12HD065987 (T.L.W.) from the Office of Women’s Health Research; and by Center for Translational Science Activities grant UL1 TR000135 from the National Center for Advancing Translational Sciences , a component of the NIH. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. The writing of the manuscript and the decision to submit it for publication were solely the authors’ responsibilities. The authors have nothing to disclose. Original article
Publisher Copyright:
© 2015 Mayo Foundation for Medical Education and Research.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Objective To determine whether women who had a hypertensive pregnancy disorder (HPD) have elevated uric acid concentrations decades after pregnancy as compared with women who had normotensive pregnancies. Patients and Methods The Genetic Epidemiology Network of Arteriopathy study measured uric acid concentrations in Hispanic (30%), non-Hispanic white (28%), and non-Hispanic black (42%) women (mean age, 60±10 years). This cross-sectional study was conducted between July 1, 2000, and December 31, 2004. Hispanic participants were recruited from families with high rates of diabetes, whereas non-Hispanic participants were recruited from families with high rates of hypertension. This analysis compared uric acid concentrations in women with a history of normotensive (n=1846) or hypertensive (n=408) pregnancies by logistic regression. Results Women who had an HPD had higher uric acid concentrations (median, 5.7 mg/dL vs 5.3 mg/dL; P<.001) and were more likely to have uric acid concentrations above 5.5 mg/dL (54.4% vs 42.4%; P=.001) than were women who had normotensive pregnancies. These differences persisted after adjusting for traditional cardiovascular risk factors, comorbidities, and other factors that affect uric acid concentrations. A family-based subgroup analysis comparing uric acid concentrations in women who had an HPD (n=308) and their parous sisters who had normotensive pregnancies (n=250) gave similar results (median uric acid concentrations, 5.7 mg/dL vs 5.2 mg/dL, P=0.02; proportion of women with uric acid concentrations >5.5 mg/dL, 54.0% vs 40.3%, P<.001). Conclusion Decades after pregnancy, women who had an HPD have higher uric acid concentrations. This effect does not appear to be explained by a familial predisposition to elevated uric acid concentrations.
AB - Objective To determine whether women who had a hypertensive pregnancy disorder (HPD) have elevated uric acid concentrations decades after pregnancy as compared with women who had normotensive pregnancies. Patients and Methods The Genetic Epidemiology Network of Arteriopathy study measured uric acid concentrations in Hispanic (30%), non-Hispanic white (28%), and non-Hispanic black (42%) women (mean age, 60±10 years). This cross-sectional study was conducted between July 1, 2000, and December 31, 2004. Hispanic participants were recruited from families with high rates of diabetes, whereas non-Hispanic participants were recruited from families with high rates of hypertension. This analysis compared uric acid concentrations in women with a history of normotensive (n=1846) or hypertensive (n=408) pregnancies by logistic regression. Results Women who had an HPD had higher uric acid concentrations (median, 5.7 mg/dL vs 5.3 mg/dL; P<.001) and were more likely to have uric acid concentrations above 5.5 mg/dL (54.4% vs 42.4%; P=.001) than were women who had normotensive pregnancies. These differences persisted after adjusting for traditional cardiovascular risk factors, comorbidities, and other factors that affect uric acid concentrations. A family-based subgroup analysis comparing uric acid concentrations in women who had an HPD (n=308) and their parous sisters who had normotensive pregnancies (n=250) gave similar results (median uric acid concentrations, 5.7 mg/dL vs 5.2 mg/dL, P=0.02; proportion of women with uric acid concentrations >5.5 mg/dL, 54.0% vs 40.3%, P<.001). Conclusion Decades after pregnancy, women who had an HPD have higher uric acid concentrations. This effect does not appear to be explained by a familial predisposition to elevated uric acid concentrations.
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U2 - 10.1016/j.mayocp.2015.05.020
DO - 10.1016/j.mayocp.2015.05.020
M3 - Article
C2 - 26260220
AN - SCOPUS:84940609558
VL - 90
SP - 1207
EP - 1216
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
SN - 0025-6196
IS - 9
ER -