Urgent therapy for acute stroke: Effects of a stroke trial on untreated patients

William G. Barsan, Thomas G Brott, Joseph P. Broderick, E. Clarke Haley, David E. Levy, John R. Marler

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Background and Purpose: As part of the recruitment efforts for the National Institutes of Health Tissue Plasminogen Activator Pilot Study, public education and awareness campaigns were conducted to encourage early hospital arrival. We evaluated the change in arrival times during the course of the study for all stroke patients, including those who were not entered into study. Methods: Data were gathered on all patients presenting within 24 hours of stroke onset to all of the study hospitals. Coincident with the start of the study, educational and promotional programs, which stressed signs and symptoms of stroke and the need to call 911, were presented to physicians, paramedical personnel, and the public. The study was divided into four quartiles to analyze differences in time to hospital arrival and use of 911. Results: Of 2099 patients screened, time data were available on 1116. During the course of the study, the mean time from symptom onset to hospital arrival declined significantly (3.2 hours versus 1.5 hours). Patients arrived for treatment sooner at community hospitals than at university/teaching hospitals. The use of 911 increased from 39% in the first quartile of the study to 60% in the fourth quartile. This was a consistent finding in all study sites. Increased use of 911 was seen almost exclusively in patients with nonhemorrhagic stroke. Conclusions: Times from stroke onset to hospital arrival decreased significantly during the course of the National Institutes of Health Tissue Plasminogen Activator Pilot Study. Significantly increased use of 911 was the likely major explanation for the shortened arrival times. The decrease in arrival times may be a consequence of the public and professional education programs conducted at all study sites.

Original languageEnglish (US)
Pages (from-to)2132-2137
Number of pages6
JournalStroke
Volume25
Issue number11
StatePublished - Nov 1994
Externally publishedYes

Fingerprint

Stroke
National Institutes of Health (U.S.)
Tissue Plasminogen Activator
Therapeutics
Allied Health Personnel
Professional Education
Community Hospital
Teaching Hospitals
Signs and Symptoms
Physicians
Education

Keywords

  • clinical trials
  • emergency medical services
  • health education

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Barsan, W. G., Brott, T. G., Broderick, J. P., Haley, E. C., Levy, D. E., & Marler, J. R. (1994). Urgent therapy for acute stroke: Effects of a stroke trial on untreated patients. Stroke, 25(11), 2132-2137.

Urgent therapy for acute stroke : Effects of a stroke trial on untreated patients. / Barsan, William G.; Brott, Thomas G; Broderick, Joseph P.; Haley, E. Clarke; Levy, David E.; Marler, John R.

In: Stroke, Vol. 25, No. 11, 11.1994, p. 2132-2137.

Research output: Contribution to journalArticle

Barsan, WG, Brott, TG, Broderick, JP, Haley, EC, Levy, DE & Marler, JR 1994, 'Urgent therapy for acute stroke: Effects of a stroke trial on untreated patients', Stroke, vol. 25, no. 11, pp. 2132-2137.
Barsan WG, Brott TG, Broderick JP, Haley EC, Levy DE, Marler JR. Urgent therapy for acute stroke: Effects of a stroke trial on untreated patients. Stroke. 1994 Nov;25(11):2132-2137.
Barsan, William G. ; Brott, Thomas G ; Broderick, Joseph P. ; Haley, E. Clarke ; Levy, David E. ; Marler, John R. / Urgent therapy for acute stroke : Effects of a stroke trial on untreated patients. In: Stroke. 1994 ; Vol. 25, No. 11. pp. 2132-2137.
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