Abstract
Background/Aims: Hyperuricemia is associated with obesity and the metabolic syndrome. URAT1 is a urate transporter, and we tested the association of URAT1 transporter gene (SLC22A12) polymorphisms with obesity and the metabolic syndrome in hypertensive subjects. Methods: Patients with essential hypertension (n = 414) from a randomized controlled study were genotyped for SLC22A12 SNPs rs11602903, rs505802 and rs11231825. Results: In Caucasians, SLC22A12 SNPs were associated with the body mass index (BMI). rs11602903 was associated with BMI (p < 0.0001), waist circumference (p = 0.003), HDL cholesterol (p = 0.018) and the metabolic syndrome (p = 0.033), and accounted for 7% of the variation of BMI in Caucasians. In African Americans, SLC22A12 SNP rs11602903 was not associated with BMI, waist circumference, HDL cholesterol or triglycerides. Conclusion: The URAT1 gene SLC22A12 polymorphism may play a role in obesity and the metabolic syndrome in Caucasian hypertensive subjects.
Original language | English (US) |
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Pages (from-to) | 477-482 |
Number of pages | 6 |
Journal | Kidney and Blood Pressure Research |
Volume | 35 |
Issue number | 6 |
DOIs | |
State | Published - Feb 2013 |
Keywords
- Hypertension
- Metabolic syndrome
- Obesity
- SLC22A12 polymorphisms
- URAT1
- Uric acid
ASJC Scopus subject areas
- Nephrology
- Cardiology and Cardiovascular Medicine