3 Citations (Scopus)

Abstract

Aim: AV-1451 is an imaging agent labeled with the positron-emitting radiolabel Fluorine-18. 18F-AV-1451 binds paired helical filament tau (PHF-tau), a pathology related to Alzheimer’s disease. In our study of AV-1451 uptake in the brains of cognitively normal subjects, we noted a case of a meningioma with visually significant uptake of AV-1451. Objective: We initiated the present retrospective study to further examine cases of meningioma that underwent AV-1451 imaging. Methods: We searched the patient records of 650 patients who had undergone AV-1451 at our institution for the keyword “meningioma” to identify potential cases. PET/CT and MRI results were visually reviewed and semi-quantitative analysis of PET was performed. A paired student’s t test was run between background and tumor standard uptake values. Fisher’s exact test was used to examine the association between AV-1451 uptake and presence of calcifications on CT. Results: We identified 12 cases of meningioma, 58% (7/12) of which demonstrated uptake greater than background using both visual analysis and tumor-to-normal cortex ratios (T/N + 1.90 ± 0.83). The paired student’s t test revealed no statistically significant difference between background and tumor standard uptake values (p = 0.09); however, cases with a T/N ratio greater than one showed statistically higher uptake in tumor tissue (p = 0.01). A significant association was noted between AV-1451 uptake and presence of calcifications (p = 0.01). Conclusion: AV-1451 PET imaging should be reviewed concurrently with anatomic imaging to prevent misleading interpretations of PHF-tau distribution due to meningiomas.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalAnnals of Nuclear Medicine
DOIs
StateAccepted/In press - Sep 8 2017

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Meningioma
Neoplasms
Students
Fluorine
Alzheimer Disease
Retrospective Studies
Electrons
Pathology
Brain

Keywords

  • AV-1451
  • Imaging
  • Meningioma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

@article{180bcad7703e4f169e7d7d3dfb91701e,
title = "Uptake of AV-1451 in meningiomas",
abstract = "Aim: AV-1451 is an imaging agent labeled with the positron-emitting radiolabel Fluorine-18. 18F-AV-1451 binds paired helical filament tau (PHF-tau), a pathology related to Alzheimer’s disease. In our study of AV-1451 uptake in the brains of cognitively normal subjects, we noted a case of a meningioma with visually significant uptake of AV-1451. Objective: We initiated the present retrospective study to further examine cases of meningioma that underwent AV-1451 imaging. Methods: We searched the patient records of 650 patients who had undergone AV-1451 at our institution for the keyword “meningioma” to identify potential cases. PET/CT and MRI results were visually reviewed and semi-quantitative analysis of PET was performed. A paired student’s t test was run between background and tumor standard uptake values. Fisher’s exact test was used to examine the association between AV-1451 uptake and presence of calcifications on CT. Results: We identified 12 cases of meningioma, 58{\%} (7/12) of which demonstrated uptake greater than background using both visual analysis and tumor-to-normal cortex ratios (T/N + 1.90 ± 0.83). The paired student’s t test revealed no statistically significant difference between background and tumor standard uptake values (p = 0.09); however, cases with a T/N ratio greater than one showed statistically higher uptake in tumor tissue (p = 0.01). A significant association was noted between AV-1451 uptake and presence of calcifications (p = 0.01). Conclusion: AV-1451 PET imaging should be reviewed concurrently with anatomic imaging to prevent misleading interpretations of PHF-tau distribution due to meningiomas.",
keywords = "AV-1451, Imaging, Meningioma",
author = "Bruinsma, {Tyler J.} and Johnson, {Derek R.} and Ping Fang and Matthew Senjem and Josephs, {Keith Anthony} and Whitwell, {Jennifer Lynn} and Boeve, {Bradley F} and Mukesh Pandey and Kantarci, {Kejal M} and Jones, {David T} and Vemuri, {Prashanthi D} and Murray, {Melissa E} and Jonathan Graff-Radford and Christopher Schwarz and Knopman, {David S} and Petersen, {Ronald Carl} and Jack, {Clifford R Jr.} and Val Lowe",
year = "2017",
month = "9",
day = "8",
doi = "10.1007/s12149-017-1205-0",
language = "English (US)",
pages = "1--8",
journal = "Annals of Nuclear Medicine",
issn = "0914-7187",
publisher = "Springer Japan",

}

TY - JOUR

T1 - Uptake of AV-1451 in meningiomas

AU - Bruinsma, Tyler J.

AU - Johnson, Derek R.

AU - Fang, Ping

AU - Senjem, Matthew

AU - Josephs, Keith Anthony

AU - Whitwell, Jennifer Lynn

AU - Boeve, Bradley F

AU - Pandey, Mukesh

AU - Kantarci, Kejal M

AU - Jones, David T

AU - Vemuri, Prashanthi D

AU - Murray, Melissa E

AU - Graff-Radford, Jonathan

AU - Schwarz, Christopher

AU - Knopman, David S

AU - Petersen, Ronald Carl

AU - Jack, Clifford R Jr.

AU - Lowe, Val

PY - 2017/9/8

Y1 - 2017/9/8

N2 - Aim: AV-1451 is an imaging agent labeled with the positron-emitting radiolabel Fluorine-18. 18F-AV-1451 binds paired helical filament tau (PHF-tau), a pathology related to Alzheimer’s disease. In our study of AV-1451 uptake in the brains of cognitively normal subjects, we noted a case of a meningioma with visually significant uptake of AV-1451. Objective: We initiated the present retrospective study to further examine cases of meningioma that underwent AV-1451 imaging. Methods: We searched the patient records of 650 patients who had undergone AV-1451 at our institution for the keyword “meningioma” to identify potential cases. PET/CT and MRI results were visually reviewed and semi-quantitative analysis of PET was performed. A paired student’s t test was run between background and tumor standard uptake values. Fisher’s exact test was used to examine the association between AV-1451 uptake and presence of calcifications on CT. Results: We identified 12 cases of meningioma, 58% (7/12) of which demonstrated uptake greater than background using both visual analysis and tumor-to-normal cortex ratios (T/N + 1.90 ± 0.83). The paired student’s t test revealed no statistically significant difference between background and tumor standard uptake values (p = 0.09); however, cases with a T/N ratio greater than one showed statistically higher uptake in tumor tissue (p = 0.01). A significant association was noted between AV-1451 uptake and presence of calcifications (p = 0.01). Conclusion: AV-1451 PET imaging should be reviewed concurrently with anatomic imaging to prevent misleading interpretations of PHF-tau distribution due to meningiomas.

AB - Aim: AV-1451 is an imaging agent labeled with the positron-emitting radiolabel Fluorine-18. 18F-AV-1451 binds paired helical filament tau (PHF-tau), a pathology related to Alzheimer’s disease. In our study of AV-1451 uptake in the brains of cognitively normal subjects, we noted a case of a meningioma with visually significant uptake of AV-1451. Objective: We initiated the present retrospective study to further examine cases of meningioma that underwent AV-1451 imaging. Methods: We searched the patient records of 650 patients who had undergone AV-1451 at our institution for the keyword “meningioma” to identify potential cases. PET/CT and MRI results were visually reviewed and semi-quantitative analysis of PET was performed. A paired student’s t test was run between background and tumor standard uptake values. Fisher’s exact test was used to examine the association between AV-1451 uptake and presence of calcifications on CT. Results: We identified 12 cases of meningioma, 58% (7/12) of which demonstrated uptake greater than background using both visual analysis and tumor-to-normal cortex ratios (T/N + 1.90 ± 0.83). The paired student’s t test revealed no statistically significant difference between background and tumor standard uptake values (p = 0.09); however, cases with a T/N ratio greater than one showed statistically higher uptake in tumor tissue (p = 0.01). A significant association was noted between AV-1451 uptake and presence of calcifications (p = 0.01). Conclusion: AV-1451 PET imaging should be reviewed concurrently with anatomic imaging to prevent misleading interpretations of PHF-tau distribution due to meningiomas.

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KW - Meningioma

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U2 - 10.1007/s12149-017-1205-0

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