Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation

LongJun Wu, Hiroki Toyoda, Ming Gao Zhao, Yong Seok Lee, Jianrong Tang, Shanelle W. Ko, Heng Jia Yong, Fanny W F Shum, Celina V. Zerbinatti, Guojun D Bu, Feng Wei, Tian Le Xu, Louis J. Muglia, Zhou Feng Chen, Yves P. Auberson, Bong Kiun Kaang, Min Zhuo

Research output: Contribution to journalArticle

174 Citations (Scopus)

Abstract

Transgenic overexpression of NMDA NR2B receptors in forebrain regions increased behavioral responses to persistent inflammatory pain. However, it is not known whether inflammation leads to the upregulation of NR2B receptors in these regions. Here, we show that peripheral inflammation increased the expression of NMDA NR2B receptors and NR2B receptor-mediated synaptic currents in the anterior cingulate cortex (ACC). In freely moving mice, the increase in NR2B receptors after inflammation contributed to enhanced NMDA receptor-mediated responses in the ACC. Inhibition of NR2B receptors in the ACC selectively reduced behavioral sensitization related to inflammation. Our results demonstrate that the upregulation of NR2B receptors in the ACC contributes to behavioral sensitization caused by inflammation.

Original languageEnglish (US)
Pages (from-to)11107-11116
Number of pages10
JournalJournal of Neuroscience
Volume25
Issue number48
DOIs
StatePublished - Nov 30 2005
Externally publishedYes

Fingerprint

Prosencephalon
Gyrus Cinguli
Up-Regulation
Inflammation
Neurotransmitter Receptor
N-Methyl-D-Aspartate Receptors
NR2B NMDA receptor
Pain

Keywords

  • Anterior cingulate cortex
  • Hyperalgesia
  • Inflammation
  • NMDA receptors
  • NR2B
  • Pain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation. / Wu, LongJun; Toyoda, Hiroki; Zhao, Ming Gao; Lee, Yong Seok; Tang, Jianrong; Ko, Shanelle W.; Yong, Heng Jia; Shum, Fanny W F; Zerbinatti, Celina V.; Bu, Guojun D; Wei, Feng; Xu, Tian Le; Muglia, Louis J.; Chen, Zhou Feng; Auberson, Yves P.; Kaang, Bong Kiun; Zhuo, Min.

In: Journal of Neuroscience, Vol. 25, No. 48, 30.11.2005, p. 11107-11116.

Research output: Contribution to journalArticle

Wu, L, Toyoda, H, Zhao, MG, Lee, YS, Tang, J, Ko, SW, Yong, HJ, Shum, FWF, Zerbinatti, CV, Bu, GD, Wei, F, Xu, TL, Muglia, LJ, Chen, ZF, Auberson, YP, Kaang, BK & Zhuo, M 2005, 'Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation', Journal of Neuroscience, vol. 25, no. 48, pp. 11107-11116. https://doi.org/10.1523/JNEUROSCI.1678-05.2005
Wu, LongJun ; Toyoda, Hiroki ; Zhao, Ming Gao ; Lee, Yong Seok ; Tang, Jianrong ; Ko, Shanelle W. ; Yong, Heng Jia ; Shum, Fanny W F ; Zerbinatti, Celina V. ; Bu, Guojun D ; Wei, Feng ; Xu, Tian Le ; Muglia, Louis J. ; Chen, Zhou Feng ; Auberson, Yves P. ; Kaang, Bong Kiun ; Zhuo, Min. / Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation. In: Journal of Neuroscience. 2005 ; Vol. 25, No. 48. pp. 11107-11116.
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