Upper tract urothelial carcinoma topical issue 2016: treatment of metastatic cancer

M. N. Pham; A. B. Apolo; M. De Santis; M. D. Galsky; B. C. Leibovich; L. L. Pisters; A. O. Siefker-Radtke; G. Sonpavde; G. D. Steinberg; C. N. Sternberg; S. T. Tagawa; A. Z. Weizer; M. E. Woods; M. I. Milowsky

doi:10.1007/s00345-016-1885-4

Upper tract urothelial carcinoma topical issue 2016: treatment of metastatic cancer

M. N. Pham, A. B. Apolo, M. De Santis, M. D. Galsky, B. C. Leibovich, L. L. Pisters, A. O. Siefker-Radtke, G. Sonpavde, G. D. Steinberg, C. N. Sternberg, S. T. Tagawa, A. Z. Weizer, M. E. Woods, M. I. Milowsky

Urology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Purpose: To review the management of metastatic upper tract urothelial carcinoma (UTUC) including recent advances in targeted and immune therapies as an update to the 2014 joint international consultation on UTUC, co-sponsored by the Société Internationale d’Urologie and International Consultation on Urological Diseases. Methods: A PubMed database search was performed between January 2013 and May 2016 related to the treatment of metastatic UTUC, and 54 studies were selected for inclusion. Results: The management of patients with metastatic UTUC is primarily an extrapolation from evidence guiding the management of metastatic urothelial carcinoma of the bladder. The first-line therapy for metastatic UTUC is platinum-based combination chemotherapy. Standard second-line therapies are limited and ineffective. Patients with UTUC who progress following platinum-based chemotherapy are encouraged to participate in clinical trials. Recent advances in genomic profiling present exciting opportunities to guide the use of targeted therapy. Immunotherapy with checkpoint inhibitors has demonstrated extremely promising results. Retrospective studies provide support for post-chemotherapy surgery in appropriately selected patients. Conclusions: The management of metastatic UTUC requires a multi-disciplinary approach. New insights from genomic profiling using targeted therapies, novel immunotherapies, and surgery represent promising avenues for further therapeutic exploration.

Original language	English (US)
Pages (from-to)	367-378
Number of pages	12
Journal	World Journal of Urology
Volume	35
Issue number	3
DOIs	https://doi.org/10.1007/s00345-016-1885-4
State	Published - Mar 1 2017

Keywords

Anti-PD-1
Anti-PD-L1
Chemotherapy
Immune checkpoint inhibitors
Immunotherapy
Targeted therapy
Upper tract urothelial carcinoma (UTUC)

ASJC Scopus subject areas

Urology

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Pham, M. N., Apolo, A. B., De Santis, M., Galsky, M. D., Leibovich, B. C., Pisters, L. L., Siefker-Radtke, A. O., Sonpavde, G., Steinberg, G. D., Sternberg, C. N., Tagawa, S. T., Weizer, A. Z., Woods, M. E., & Milowsky, M. I. (2017). Upper tract urothelial carcinoma topical issue 2016: treatment of metastatic cancer. World Journal of Urology, 35(3), 367-378. https://doi.org/10.1007/s00345-016-1885-4

Upper tract urothelial carcinoma topical issue 2016 : treatment of metastatic cancer. / Pham, M. N.; Apolo, A. B.; De Santis, M.; Galsky, M. D.; Leibovich, B. C.; Pisters, L. L.; Siefker-Radtke, A. O.; Sonpavde, G.; Steinberg, G. D.; Sternberg, C. N.; Tagawa, S. T.; Weizer, A. Z.; Woods, M. E.; Milowsky, M. I.

In: World Journal of Urology, Vol. 35, No. 3, 01.03.2017, p. 367-378.

Research output: Contribution to journal › Article › peer-review

Pham, MN, Apolo, AB, De Santis, M, Galsky, MD, Leibovich, BC, Pisters, LL, Siefker-Radtke, AO, Sonpavde, G, Steinberg, GD, Sternberg, CN, Tagawa, ST, Weizer, AZ, Woods, ME & Milowsky, MI 2017, 'Upper tract urothelial carcinoma topical issue 2016: treatment of metastatic cancer', World Journal of Urology, vol. 35, no. 3, pp. 367-378. https://doi.org/10.1007/s00345-016-1885-4

Pham, M. N. ; Apolo, A. B. ; De Santis, M. ; Galsky, M. D. ; Leibovich, B. C. ; Pisters, L. L. ; Siefker-Radtke, A. O. ; Sonpavde, G. ; Steinberg, G. D. ; Sternberg, C. N. ; Tagawa, S. T. ; Weizer, A. Z. ; Woods, M. E. ; Milowsky, M. I. / Upper tract urothelial carcinoma topical issue 2016 : treatment of metastatic cancer. In: World Journal of Urology. 2017 ; Vol. 35, No. 3. pp. 367-378.

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abstract = "Purpose: To review the management of metastatic upper tract urothelial carcinoma (UTUC) including recent advances in targeted and immune therapies as an update to the 2014 joint international consultation on UTUC, co-sponsored by the Soci{\'e}t{\'e} Internationale d{\textquoteright}Urologie and International Consultation on Urological Diseases. Methods: A PubMed database search was performed between January 2013 and May 2016 related to the treatment of metastatic UTUC, and 54 studies were selected for inclusion. Results: The management of patients with metastatic UTUC is primarily an extrapolation from evidence guiding the management of metastatic urothelial carcinoma of the bladder. The first-line therapy for metastatic UTUC is platinum-based combination chemotherapy. Standard second-line therapies are limited and ineffective. Patients with UTUC who progress following platinum-based chemotherapy are encouraged to participate in clinical trials. Recent advances in genomic profiling present exciting opportunities to guide the use of targeted therapy. Immunotherapy with checkpoint inhibitors has demonstrated extremely promising results. Retrospective studies provide support for post-chemotherapy surgery in appropriately selected patients. Conclusions: The management of metastatic UTUC requires a multi-disciplinary approach. New insights from genomic profiling using targeted therapies, novel immunotherapies, and surgery represent promising avenues for further therapeutic exploration.",

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AU - Apolo, A. B.

AU - De Santis, M.

AU - Galsky, M. D.

AU - Leibovich, B. C.

AU - Pisters, L. L.

AU - Siefker-Radtke, A. O.

AU - Sonpavde, G.

AU - Steinberg, G. D.

AU - Sternberg, C. N.

AU - Tagawa, S. T.

AU - Weizer, A. Z.

AU - Woods, M. E.

AU - Milowsky, M. I.

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