Updates on morphea: Role of vascular injury and advances in treatment

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Morphea and systemic sclerosis are fibrosing disorders of the skin that share common inflammatory and immunologic pathways that are responsible for the vascular changes, increased collagen production, and extracellular matrix proliferation seen in both conditions. Recent advances in molecular biology techniques have furthered our knowledge of the potential underlying pathogenic mechanisms and offer new and provocative areas of research for novel diagnostic and therapeutic interventions. This review focuses on the role of vascular injury in the development of morphea, the use of ultrasonography as a diagnostic modality, and well-established and newly proposed treatments.

Original languageEnglish (US)
Article number467808
JournalAutoimmune Diseases
Volume2013
DOIs
StatePublished - 2013

Fingerprint

Localized Scleroderma
Vascular System Injuries
Systemic Scleroderma
Extracellular Matrix
Blood Vessels
Molecular Biology
Ultrasonography
Collagen
Skin
Research
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology and Microbiology (miscellaneous)
  • Immunology

Cite this

Updates on morphea : Role of vascular injury and advances in treatment. / Sartori Valinotti, Julio; Tollefson, Megha M; Reed, Ann M.

In: Autoimmune Diseases, Vol. 2013, 467808, 2013.

Research output: Contribution to journalArticle

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