TY - JOUR
T1 - Updated options for liver-limited metastatic colorectal cancer
AU - Alberts, Steven R.
N1 - Funding Information:
Dr Alberts has received research support from Bristol-Myers Squibb Company; Pfizer Inc.; and sanofi-aventis U.S.
PY - 2008/12
Y1 - 2008/12
N2 - Liver metastases from colorectal cancer (CRC) are common in patients presenting with an initial diagnosis of metastatic disease or at the time of recurrence.Without treatment, patients with metastatic disease have a poor prognosis. Surgical resection of the metastases might provide long-term benefit.; however, the size, number, or location of the metastases can limit the ability to perform a resection. The use of chemotherapy, both systemic and via hepatic artery infusion, in patients undergoing surgery for liver metastases from CRC has augmented the long-term survival benefits and even the cure obtained in some patients with surgery. Chemotherapy might also convert a portion of patients with initially unre- sectable liver metastases to resectable. A growing body of literature is helping to define the role of chemotherapy for potentially resectable liver metastases and for initially unresectable liver metastases. The introduction of newer agents such as oxaliplatin and irinotecan, and targeted agents such as cetuximab and bevacizumab, has led to meaningful improvements in response rates and survival over those previously achieved with 5-fluorouracil. Further trials are needed to refine the use of chemotherapy and targeted agents in the management of patients with liver metastases.
AB - Liver metastases from colorectal cancer (CRC) are common in patients presenting with an initial diagnosis of metastatic disease or at the time of recurrence.Without treatment, patients with metastatic disease have a poor prognosis. Surgical resection of the metastases might provide long-term benefit.; however, the size, number, or location of the metastases can limit the ability to perform a resection. The use of chemotherapy, both systemic and via hepatic artery infusion, in patients undergoing surgery for liver metastases from CRC has augmented the long-term survival benefits and even the cure obtained in some patients with surgery. Chemotherapy might also convert a portion of patients with initially unre- sectable liver metastases to resectable. A growing body of literature is helping to define the role of chemotherapy for potentially resectable liver metastases and for initially unresectable liver metastases. The introduction of newer agents such as oxaliplatin and irinotecan, and targeted agents such as cetuximab and bevacizumab, has led to meaningful improvements in response rates and survival over those previously achieved with 5-fluorouracil. Further trials are needed to refine the use of chemotherapy and targeted agents in the management of patients with liver metastases.
KW - Conversion therapy
KW - Epidermal growth factor inhibitors
KW - Hepatic artery infusion
KW - Liver metastases
KW - Perioperative chemotherapy
UR - http://www.scopus.com/inward/record.url?scp=58949104198&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58949104198&partnerID=8YFLogxK
U2 - 10.3816/CCC.2008.s.009
DO - 10.3816/CCC.2008.s.009
M3 - Article
C2 - 19064408
AN - SCOPUS:58949104198
SN - 1533-0028
VL - 7
SP - S58-S62
JO - Clinical colorectal cancer
JF - Clinical colorectal cancer
IS - SUPPL. 2
ER -