Update on the classification of T-cell lymphomas, Hodgkin lymphomas, and histiocytic/dendritic cell neoplasms

Research output: Contribution to journalReview article

Abstract

Introduction: The classification of lymphomas is based on the postulated normal counterparts of lymphoid neoplasms and currently constitutes over 100 definite or provisional entities. As this number of entities implies, lymphomas show marked pathological, genetic, and clinical heterogeneity. Recent molecular findings have significantly advanced our understanding of lymphomas. Areas covered: The World Health Organization (WHO) classification of lymphoid neoplasms was updated in 2017. The present review summarizes the new findings that have been gained in the areas of mature T-cell neoplasms, Hodgkin lymphomas, and histiocytic/dendritic cell neoplasms since the publication of the 2017 WHO classification. Expert opinion: Although formal revisions to the WHO classification are published only periodically, our understanding of the pathologic, genetic, and clinical features of lymphoid neoplasms is constantly evolving, particularly in the age of –omics technologies and targeted therapeutics. Even in the relatively short time since the publication of the 2017 WHO classification, many significant findings have been identified in the entities covered in this review.

Original languageEnglish (US)
Pages (from-to)833-843
Number of pages11
JournalExpert Review of Hematology
Volume12
Issue number10
DOIs
StatePublished - Oct 3 2019

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Keywords

  • Adult T-cell leukemia/lymphoma
  • EBV-associated T-/NK-cell neoplasms
  • genetic abnormalities
  • histiocytic/dendritic cell tumors
  • Hodgkin lymphoma
  • mature T-cell neoplasms
  • WHO classification

ASJC Scopus subject areas

  • Hematology

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