Update on myocarditis

Ingrid Kindermann, Christine Barth, Felix Mahfoud, Christian Ukena, Matthias Lenski, Ali Yilmaz, Karin Klingel, Reinhard Kandolf, Udo Sechtem, Leslie T Jr. Cooper, Michael Bhm

Research output: Contribution to journalArticle

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Abstract

Myocarditis is an inflammatory disease of the heart frequently resulting from viral infections and/or post-viral immune-mediated responses. It is one of the important causes of dilated cardiomyopathy worldwide. The diagnosis is presumed on clinical presentation and noninvasive diagnostic methods such as cardiovascular magnetic resonance imaging. Endomyocardial biopsy remains the gold standard for in vivo diagnosis of myocarditis. The therapeutic and prognostic benefits of endomyocardial biopsy results have recently been demonstrated in several clinical trials. Although remarkable advances in diagnosis, understanding of pathophysiological mechanisms, and treatment of acute myocarditis were gained during the last years, no standard treatment strategies could be defined as yet, apart from standard heart failure therapy and physical rest. In severe cases, mechanical support or heart transplantation may become necessary. There is some evidence that immunosuppressive and immunomodulating therapy are effective for chronic, virus-negative inflammatory cardiomyopathy. Further investigations by controlled, randomized studies are needed to definitively determine their role in the treatment of myocarditis.

Original languageEnglish (US)
Pages (from-to)779-792
Number of pages14
JournalJournal of the American College of Cardiology
Volume59
Issue number9
DOIs
StatePublished - Feb 28 2012

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Myocarditis
Biopsy
Dilated Cardiomyopathy
Virus Diseases
Heart Transplantation
Immunosuppressive Agents
Cardiomyopathies
Heart Diseases
Therapeutics
Heart Failure
Magnetic Resonance Imaging
Clinical Trials
Viruses

Keywords

  • heart failure
  • inflammatory cardiomyopathy
  • myocarditis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Kindermann, I., Barth, C., Mahfoud, F., Ukena, C., Lenski, M., Yilmaz, A., ... Bhm, M. (2012). Update on myocarditis. Journal of the American College of Cardiology, 59(9), 779-792. https://doi.org/10.1016/j.jacc.2011.09.074

Update on myocarditis. / Kindermann, Ingrid; Barth, Christine; Mahfoud, Felix; Ukena, Christian; Lenski, Matthias; Yilmaz, Ali; Klingel, Karin; Kandolf, Reinhard; Sechtem, Udo; Cooper, Leslie T Jr.; Bhm, Michael.

In: Journal of the American College of Cardiology, Vol. 59, No. 9, 28.02.2012, p. 779-792.

Research output: Contribution to journalArticle

Kindermann, I, Barth, C, Mahfoud, F, Ukena, C, Lenski, M, Yilmaz, A, Klingel, K, Kandolf, R, Sechtem, U, Cooper, LTJ & Bhm, M 2012, 'Update on myocarditis', Journal of the American College of Cardiology, vol. 59, no. 9, pp. 779-792. https://doi.org/10.1016/j.jacc.2011.09.074
Kindermann I, Barth C, Mahfoud F, Ukena C, Lenski M, Yilmaz A et al. Update on myocarditis. Journal of the American College of Cardiology. 2012 Feb 28;59(9):779-792. https://doi.org/10.1016/j.jacc.2011.09.074
Kindermann, Ingrid ; Barth, Christine ; Mahfoud, Felix ; Ukena, Christian ; Lenski, Matthias ; Yilmaz, Ali ; Klingel, Karin ; Kandolf, Reinhard ; Sechtem, Udo ; Cooper, Leslie T Jr. ; Bhm, Michael. / Update on myocarditis. In: Journal of the American College of Cardiology. 2012 ; Vol. 59, No. 9. pp. 779-792.
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